Repeated Systemic Administration of Human Adipose-Derived Stem Cells Attenuates Overt Diabetic Nephropathy in Rats

Adipose-derived stem cells (ASCs) can alleviate acute kidney injury and promote kidney cell regeneration and repair. To investigate the role of ASCs in diabetic nephropathy (DN), Sprague-Dawley rats were made diabetic by intraperitoneal injection of streptozotocin (STZ) after uninephrectomy. After 1...

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Veröffentlicht in:	Stem cells and development 2013-12, Vol.22 (23), p.374-3086
Hauptverfasser:	Zhang, Li, Li, Kanghua, Liu, Xiangfei, Li, Diangeng, Luo, Congjuan, Fu, Bo, Cui, Shaoyuan, Zhu, Fei, Zhao, Robert Chunhua, Chen, Xiangmei
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology Animals Diabetic Nephropathies - complications Diabetic Nephropathies - pathology Diabetic Nephropathies - therapy Glial Cell Line-Derived Neurotrophic Factor - metabolism Humans Hyperglycemia - complications Hyperglycemia - pathology Hyperglycemia - therapy Hypertrophy Islets of Langerhans - pathology Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Kidney Tubules - metabolism Kidney Tubules - pathology Male Mice Original Research Reports Podocytes - metabolism Podocytes - pathology Proteinuria - complications Proteinuria - pathology Proteinuria - therapy Rats Rats, Sprague-Dawley Stem Cell Transplantation Stem Cells - cytology
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