Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus
Highlights • Morphine decreased BDNF, TrkB and 5-HT1A mRNA expression in the serotonergic DRN. • Morphine decreased CRF-R1 and increased CRF-R2 mRNA expression in the DRN. • Opiate history and swim stress interact to reduce DRN TPH2 mRNA expression. • Opiate modulation of DRN circuits may promote 5-...
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| Veröffentlicht in: | Neuroscience 2013-12, Vol.254, p.160-172 |
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| container_title | Neuroscience |
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| creator | Lunden, J.W Kirby, L.G |
| description | Highlights • Morphine decreased BDNF, TrkB and 5-HT1A mRNA expression in the serotonergic DRN. • Morphine decreased CRF-R1 and increased CRF-R2 mRNA expression in the DRN. • Opiate history and swim stress interact to reduce DRN TPH2 mRNA expression. • Opiate modulation of DRN circuits may promote 5-HT hypofunction. • 5-HT hypofunction may contribute to vulnerability to stress-induced opiate relapse. |
| doi_str_mv | 10.1016/j.neuroscience.2013.08.071 |
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| ispartof | Neuroscience, 2013-12, Vol.254, p.160-172 |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Analgesics Animals Biological and medical sciences dorsal raphe nucleus Fundamental and applied biological sciences. Psychology gene expression Gene Expression Regulation - drug effects Male Medical sciences morphine Morphine - administration & dosage mRNA Neurology Neuropharmacology Opioid-Related Disorders - genetics Opioid-Related Disorders - metabolism Pharmacology. Drug treatments Raphe Nuclei - drug effects Raphe Nuclei - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - biosynthesis RNA, Messenger - drug effects RNA, Messenger - genetics Serotonergic Neurons - drug effects Serotonergic Neurons - metabolism serotonin stress Substance Withdrawal Syndrome - genetics Substance Withdrawal Syndrome - metabolism Vertebrates: nervous system and sense organs |
| title | Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus |
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