Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus

Highlights • Morphine decreased BDNF, TrkB and 5-HT1A mRNA expression in the serotonergic DRN. • Morphine decreased CRF-R1 and increased CRF-R2 mRNA expression in the DRN. • Opiate history and swim stress interact to reduce DRN TPH2 mRNA expression. • Opiate modulation of DRN circuits may promote 5-...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2013-12, Vol.254, p.160-172
Hauptverfasser:	Lunden, J.W, Kirby, L.G
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Biological and medical sciences dorsal raphe nucleus Fundamental and applied biological sciences. Psychology gene expression Gene Expression Regulation - drug effects Male Medical sciences morphine Morphine - administration & dosage mRNA Neurology Neuropharmacology Opioid-Related Disorders - genetics Opioid-Related Disorders - metabolism Pharmacology. Drug treatments Raphe Nuclei - drug effects Raphe Nuclei - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - biosynthesis RNA, Messenger - drug effects RNA, Messenger - genetics Serotonergic Neurons - drug effects Serotonergic Neurons - metabolism serotonin stress Substance Withdrawal Syndrome - genetics Substance Withdrawal Syndrome - metabolism Vertebrates: nervous system and sense organs
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Morphine decreased BDNF, TrkB and 5-HT1A mRNA expression in the serotonergic DRN. • Morphine decreased CRF-R1 and increased CRF-R2 mRNA expression in the DRN. • Opiate history and swim stress interact to reduce DRN TPH2 mRNA expression. • Opiate modulation of DRN circuits may promote 5-HT hypofunction. • 5-HT hypofunction may contribute to vulnerability to stress-induced opiate relapse.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2013.08.071