The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover

•Neuropilin-1 (Nrp1) bound filamin A (FlnA) directly.•Endothelial cells (ECs) expressing Nrp1 lacking a cytoplasmic domain migrated slower than wild type ECs.•Focal adhesion (FA) turnover in ECs expressing truncated Nrp1 was slower than in wild type ECs. Though the vascular endothelial growth factor...

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Veröffentlicht in:	FEBS letters 2013-11, Vol.587 (21), p.3392-3399
Hauptverfasser:	Seerapu, Himabindu Reddy, Borthakur, Susmita, Kong, Nathan, Agrawal, Sudesh, Drazba, Judy, Vasanji, Amit, Fantin, Alessandro, Ruhrberg, Christiana, Buck, Matthias, Horowitz, Arie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion Cytoplasm - metabolism Cytoplasmic domain Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Filamin A Filamins - chemistry Filamins - metabolism Focal adhesion Focal Adhesions - metabolism Mice Mutation Neuropilin-1 Neuropilin-1 - chemistry Neuropilin-1 - genetics Neuropilin-1 - metabolism Signal Transduction Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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