The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond
The cerebrospinal fluid (CSF) has attracted renewed interest as an active signaling milieu that regulates brain development, homeostasis, and disease. Advances in proteomics research have enabled an improved characterization of the CSF from development through adulthood, and key neurogenic signaling...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2012-09, Vol.69 (17), p.2863-2878 |
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| creator | Zappaterra, Mauro W. Lehtinen, Maria K. |
| description | The cerebrospinal fluid (CSF) has attracted renewed interest as an active signaling milieu that regulates brain development, homeostasis, and disease. Advances in proteomics research have enabled an improved characterization of the CSF from development through adulthood, and key neurogenic signaling pathways that are transmitted via the CSF are now being elucidated. Due to its immediate contact with neural stem cells in the developing and adult brain, the CSF’s ability to swiftly distribute signals across vast distances in the central nervous system is opening avenues to novel and exciting therapeutic approaches. In this review, we will discuss the development of the choroid plexus-CSF system, and review the current literature on how the CSF actively regulates mammalian brain development, behavior, and responses to traumatic brain injury. |
| doi_str_mv | 10.1007/s00018-012-0957-x |
| format | Article |
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| source | MEDLINE; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Adult Behavior Biochemistry Biomedical and Life Sciences Biomedicine Body fluids Brain - metabolism Brain damage Brain Injuries - cerebrospinal fluid Cell Biology Cellular biology Central nervous system Cerebrospinal Fluid - metabolism Choroid Plexus - blood supply Choroid Plexus - metabolism Humans Life Sciences Neurogenesis Proteomics Review Spine Stem cells |
| title | The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond |
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