Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: A pilot fMRI study
Abstract Failure to distinguish bipolar depression (BDd) from the unipolar depression of major depressive disorder (UDd) in adolescents has significant clinical consequences. We aimed to identify differential patterns of functional neural activity in BDd versus UDd and employed two (fearful and happ...
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| Veröffentlicht in: | Psychiatry research. Neuroimaging 2013-12, Vol.214 (3), p.277-284 |
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| creator | Diler, Rasim Somer de Almeida, Jorge Renner Cardoso Ladouceur, Cecile Birmaher, Boris Axelson, David Phillips, Mary |
| description | Abstract Failure to distinguish bipolar depression (BDd) from the unipolar depression of major depressive disorder (UDd) in adolescents has significant clinical consequences. We aimed to identify differential patterns of functional neural activity in BDd versus UDd and employed two (fearful and happy) facial expression/ gender labeling functional magnetic resonance imaging (fMRI) experiments to study emotion processing in 10 BDd (8 females, mean age=15.1±1.1) compared to age- and gender-matched 10 UDd and 10 healthy control (HC) adolescents who were age- and gender-matched to the BDd group. BDd adolescents, relative to UDd, showed significantly lower activity to both intense happy (e.g., insula and temporal cortex) and intense fearful faces (e.g., frontal precentral cortex). Although the neural regions recruited in each group were not the same, both BDd and UDd adolescents, relative to HC, showed significantly lower neural activity to intense happy and mild happy faces, but elevated neural activity to mild fearful faces. Our results indicated that patterns of neural activity to intense positive and negative emotional stimuli can help differentiate BDd from UDd in adolescents. |
| doi_str_mv | 10.1016/j.pscychresns.2013.06.013 |
| format | Article |
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We aimed to identify differential patterns of functional neural activity in BDd versus UDd and employed two (fearful and happy) facial expression/ gender labeling functional magnetic resonance imaging (fMRI) experiments to study emotion processing in 10 BDd (8 females, mean age=15.1±1.1) compared to age- and gender-matched 10 UDd and 10 healthy control (HC) adolescents who were age- and gender-matched to the BDd group. BDd adolescents, relative to UDd, showed significantly lower activity to both intense happy (e.g., insula and temporal cortex) and intense fearful faces (e.g., frontal precentral cortex). Although the neural regions recruited in each group were not the same, both BDd and UDd adolescents, relative to HC, showed significantly lower neural activity to intense happy and mild happy faces, but elevated neural activity to mild fearful faces. Our results indicated that patterns of neural activity to intense positive and negative emotional stimuli can help differentiate BDd from UDd in adolescents.</description><identifier>ISSN: 0925-4927</identifier><identifier>EISSN: 1872-7506</identifier><identifier>DOI: 10.1016/j.pscychresns.2013.06.013</identifier><identifier>PMID: 24080517</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Adolescents ; Adult and adolescent clinical studies ; Biological and medical sciences ; Bipolar depression ; Bipolar Disorder - complications ; Bipolar Disorder - diagnosis ; Bipolar Disorder - pathology ; Bipolar Disorder - physiopathology ; Bipolar disorders ; Brain Mapping ; Cerebral Cortex - pathology ; Cerebral Cortex - physiopathology ; Child ; Cross-Sectional Studies ; Depression ; Depression - complications ; Depressive Disorder, Major - complications ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - pathology ; Depressive Disorder, Major - physiopathology ; Diagnosis, Differential ; Emotion processing ; Emotions ; Facial Expression ; Fear - psychology ; Female ; Functional magnetic resonance imaging (fMRI) ; Happiness ; Humans ; Magnetic Resonance Imaging ; Major depressive disorder ; Male ; Medical sciences ; Miscellaneous ; Mood disorders ; Pilot Projects ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Radiology</subject><ispartof>Psychiatry research. Neuroimaging, 2013-12, Vol.214 (3), p.277-284</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2013 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><rights>2013 Elsevier Ireland Ltd. All rights reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c667t-319776d1dd27b1a7b594fc620e7598f0454a32a0b7adc30b557e6ec5cdbdd3393</citedby><cites>FETCH-LOGICAL-c667t-319776d1dd27b1a7b594fc620e7598f0454a32a0b7adc30b557e6ec5cdbdd3393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0925492713001856$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28007024$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24080517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Diler, Rasim Somer</creatorcontrib><creatorcontrib>de Almeida, Jorge Renner Cardoso</creatorcontrib><creatorcontrib>Ladouceur, Cecile</creatorcontrib><creatorcontrib>Birmaher, Boris</creatorcontrib><creatorcontrib>Axelson, David</creatorcontrib><creatorcontrib>Phillips, Mary</creatorcontrib><title>Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: A pilot fMRI study</title><title>Psychiatry research. Neuroimaging</title><addtitle>Psychiatry Res</addtitle><description>Abstract Failure to distinguish bipolar depression (BDd) from the unipolar depression of major depressive disorder (UDd) in adolescents has significant clinical consequences. We aimed to identify differential patterns of functional neural activity in BDd versus UDd and employed two (fearful and happy) facial expression/ gender labeling functional magnetic resonance imaging (fMRI) experiments to study emotion processing in 10 BDd (8 females, mean age=15.1±1.1) compared to age- and gender-matched 10 UDd and 10 healthy control (HC) adolescents who were age- and gender-matched to the BDd group. BDd adolescents, relative to UDd, showed significantly lower activity to both intense happy (e.g., insula and temporal cortex) and intense fearful faces (e.g., frontal precentral cortex). Although the neural regions recruited in each group were not the same, both BDd and UDd adolescents, relative to HC, showed significantly lower neural activity to intense happy and mild happy faces, but elevated neural activity to mild fearful faces. Our results indicated that patterns of neural activity to intense positive and negative emotional stimuli can help differentiate BDd from UDd in adolescents.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Bipolar depression</subject><subject>Bipolar Disorder - complications</subject><subject>Bipolar Disorder - diagnosis</subject><subject>Bipolar Disorder - pathology</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Bipolar disorders</subject><subject>Brain Mapping</subject><subject>Cerebral Cortex - pathology</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Depression</subject><subject>Depression - complications</subject><subject>Depressive Disorder, Major - complications</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Depressive Disorder, Major - pathology</subject><subject>Depressive Disorder, Major - physiopathology</subject><subject>Diagnosis, Differential</subject><subject>Emotion processing</subject><subject>Emotions</subject><subject>Facial Expression</subject><subject>Fear - psychology</subject><subject>Female</subject><subject>Functional magnetic resonance imaging (fMRI)</subject><subject>Happiness</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Major depressive disorder</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Mood disorders</subject><subject>Pilot Projects</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Radiology</subject><issn>0925-4927</issn><issn>1872-7506</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2P0zAQhiMEYsvCX0DmgMSlxY4TO-Gw0qriY6UFJD7OlmNPti6JHTxJpf4zfh4O7ZaFC5xGHj9-ZzzzZtkzRleMMvFyuxrQ7M0mAnpc5ZTxFRWrFO5lC1bJfClLKu5nC1rn5bKoc3mWPULcUprzSvCH2Vle0IqWTC6yHx9giroj2oxu58Y9GQNxfgSPQIaALmWB7CDihMTDjf51xtH1U-eI0Z5soBuIdW0LEfzo9AikcUPodExZDNFCJG0MPZn8Md3rbUiXMKT2cZY7cc7fpsESbUMHaJIoviKXZHBdGEn7_tNVKj_Z_ePsQas7hCfHeJ59ffP6y_rd8vrj26v15fXSCCHHJWe1lMIya3PZMC2bsi5aI3IKsqyrlhZloXmuaSO1NZw2ZSlBgCmNbazlvObn2cVBd5iaHuzcT5qXGqLrddyroJ3688a7jboJO8WrUogiTwIvjgIxfJ8AR9W79K2u0x7ChIqVTEjBGKP_RgtRVFXNqExofUBNDIgR2lNHjKrZJGqr7phEzSZRVKgU0tund790ennrigQ8PwIaje7aqL1x-JurKJU0LxK3PnCQFrBzEBUaB96AdRHMqGxw_9XOxV8qpnPepcLfYA-4DVP0acOKKcwVVZ9nV8-mZpxSlobMfwKmkvyg</recordid><startdate>20131230</startdate><enddate>20131230</enddate><creator>Diler, Rasim Somer</creator><creator>de Almeida, Jorge Renner Cardoso</creator><creator>Ladouceur, Cecile</creator><creator>Birmaher, Boris</creator><creator>Axelson, David</creator><creator>Phillips, Mary</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>20131230</creationdate><title>Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: A pilot fMRI study</title><author>Diler, Rasim Somer ; de Almeida, Jorge Renner Cardoso ; Ladouceur, Cecile ; Birmaher, Boris ; Axelson, David ; Phillips, Mary</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c667t-319776d1dd27b1a7b594fc620e7598f0454a32a0b7adc30b557e6ec5cdbdd3393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Bipolar depression</topic><topic>Bipolar Disorder - complications</topic><topic>Bipolar Disorder - diagnosis</topic><topic>Bipolar Disorder - pathology</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Bipolar disorders</topic><topic>Brain Mapping</topic><topic>Cerebral Cortex - pathology</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Depression</topic><topic>Depression - complications</topic><topic>Depressive Disorder, Major - complications</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Depressive Disorder, Major - pathology</topic><topic>Depressive Disorder, Major - physiopathology</topic><topic>Diagnosis, Differential</topic><topic>Emotion processing</topic><topic>Emotions</topic><topic>Facial Expression</topic><topic>Fear - psychology</topic><topic>Female</topic><topic>Functional magnetic resonance imaging (fMRI)</topic><topic>Happiness</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Major depressive disorder</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Mood disorders</topic><topic>Pilot Projects</topic><topic>Psychiatry</topic><topic>Psychology. 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Neuroimaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Diler, Rasim Somer</au><au>de Almeida, Jorge Renner Cardoso</au><au>Ladouceur, Cecile</au><au>Birmaher, Boris</au><au>Axelson, David</au><au>Phillips, Mary</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: A pilot fMRI study</atitle><jtitle>Psychiatry research. Neuroimaging</jtitle><addtitle>Psychiatry Res</addtitle><date>2013-12-30</date><risdate>2013</risdate><volume>214</volume><issue>3</issue><spage>277</spage><epage>284</epage><pages>277-284</pages><issn>0925-4927</issn><eissn>1872-7506</eissn><abstract>Abstract Failure to distinguish bipolar depression (BDd) from the unipolar depression of major depressive disorder (UDd) in adolescents has significant clinical consequences. We aimed to identify differential patterns of functional neural activity in BDd versus UDd and employed two (fearful and happy) facial expression/ gender labeling functional magnetic resonance imaging (fMRI) experiments to study emotion processing in 10 BDd (8 females, mean age=15.1±1.1) compared to age- and gender-matched 10 UDd and 10 healthy control (HC) adolescents who were age- and gender-matched to the BDd group. BDd adolescents, relative to UDd, showed significantly lower activity to both intense happy (e.g., insula and temporal cortex) and intense fearful faces (e.g., frontal precentral cortex). Although the neural regions recruited in each group were not the same, both BDd and UDd adolescents, relative to HC, showed significantly lower neural activity to intense happy and mild happy faces, but elevated neural activity to mild fearful faces. Our results indicated that patterns of neural activity to intense positive and negative emotional stimuli can help differentiate BDd from UDd in adolescents.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>24080517</pmid><doi>10.1016/j.pscychresns.2013.06.013</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adolescents Adult and adolescent clinical studies Biological and medical sciences Bipolar depression Bipolar Disorder - complications Bipolar Disorder - diagnosis Bipolar Disorder - pathology Bipolar Disorder - physiopathology Bipolar disorders Brain Mapping Cerebral Cortex - pathology Cerebral Cortex - physiopathology Child Cross-Sectional Studies Depression Depression - complications Depressive Disorder, Major - complications Depressive Disorder, Major - diagnosis Depressive Disorder, Major - pathology Depressive Disorder, Major - physiopathology Diagnosis, Differential Emotion processing Emotions Facial Expression Fear - psychology Female Functional magnetic resonance imaging (fMRI) Happiness Humans Magnetic Resonance Imaging Major depressive disorder Male Medical sciences Miscellaneous Mood disorders Pilot Projects Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Radiology |
| title | Neural activity to intense positive versus negative stimuli can help differentiate bipolar disorder from unipolar major depressive disorder in depressed adolescents: A pilot fMRI study |
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