MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma

microRNAs have been shown to regulate the chemosensitivity of cancer cells. The aim of this study is to investigate the role and mechanism of mir-23a in enhancing the anti-tumor effect of topoisomerase 2A (TOP2A) poison etoposide in human hepatocellular carcinoma (HCC). The anti-tumor effect of chem...

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Veröffentlicht in:	Molecular cancer 2013-10, Vol.12 (1), p.119-119, Article 119
Hauptverfasser:	Wang, Ning, Zhu, Meifen, Tsao, Sai-Wah, Man, Kwan, Zhang, Zhangjin, Feng, Yibin
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions 5-Fluorouracil Analysis Animals Antigens, Neoplasm - metabolism Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Base Sequence Binding Sites Cancer Cancer therapies Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Care and treatment Cell Line, Tumor Chemotherapy Cytotoxicity Diagnosis DNA Topoisomerases, Type I - genetics DNA Topoisomerases, Type I - metabolism DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Drug Resistance, Neoplasm Etoposide Etoposide - pharmacology Experiments Fluorouracil Fluorouracil - pharmacology Gene expression Gene Expression Regulation, Neoplastic Genetic aspects Health aspects Hepatoma Humans Liver cancer Liver Neoplasms, Experimental - drug therapy Liver Neoplasms, Experimental - metabolism Liver Neoplasms, Experimental - pathology Medicine Mice Mice, Inbred BALB C Mice, Nude MicroRNA MicroRNAs - genetics Poly-ADP-Ribose Binding Proteins Regulation RNA Interference Studies Tumor Burden Tumor proteins Tumor Suppressor Protein p53 - metabolism Xenograft Model Antitumor Assays
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