IL-17A is produced by breast cancer TILs and promotes chemoresistance and proliferation through ERK1/2

The proinflammatory cytokine Interleukin 17A (hereafter named IL–17A) or IL-17A producing cells are elevated in breast tumors environment and correlate with poor prognosis. Increased IL-17A is associated with ER(−) or triple negative tumors and reduced Disease Free Survival. However, the pathophysio...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2013-12, Vol.3 (1), p.3456-3456, Article 3456
Hauptverfasser:	Cochaud, Stéphanie, Giustiniani, Jérôme, Thomas, Clémence, Laprevotte, Emilie, Garbar, Christian, Savoye, Aude-Marie, Curé, Hervé, Mascaux, Corinne, Alberici, Gilles, Bonnefoy, Nathalie, Eliaou, Jean-François, Bensussan, Armand, Bastid, Jeremy
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/21 13/51 13/95 38/77 631/67/1347 631/67/580 Antibodies Antineoplastic Agents - pharmacology Biopsy Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - immunology Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Movement - drug effects Cell proliferation Cell Proliferation - drug effects Chemoresistance Chemotherapy Drug Resistance, Neoplasm Extracellular signal-regulated kinase Female Humanities and Social Sciences Humans Inflammation Interleukin-17 - biosynthesis Interleukin-17 - genetics Leukocyte migration Lymphocytes Lymphocytes T Lymphocytes, Tumor-Infiltrating - immunology Lymphocytes, Tumor-Infiltrating - metabolism MAP kinase MAP Kinase Signaling System - drug effects Medical prognosis Mitogen-Activated Protein Kinase 1 Mitogen-Activated Protein Kinase 3 multidisciplinary Receptors, Estrogen - metabolism Science Taxoids - pharmacology Tumor cell lines Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!