Chelator-Free Synthesis of a Dual-Modality PET/MRI Agent

Old technique, new application: A simple and efficient chelator‐free strategy for the synthesis of a novel dual‐modality PET/MRI agent has been developed. Labeling of radioarsenic (*AsIII and *AsV, *=71, 72, 74, 76) at the surface of superparamagnetic iron oxide nanoparticles (SPIONs) resulted in *A...

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Veröffentlicht in:	Angewandte Chemie International Edition 2013-12, Vol.52 (50), p.13319-13323
Hauptverfasser:	Chen, Feng, Ellison, Paul A., Lewis, Christina M., Hong, Hao, Zhang, Yin, Shi, Sixiang, Hernandez, Reinier, Meyerand, M. Elizabeth, Barnhart, Todd E., Cai, Weibo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals arsenic Arsenic - chemistry Cancer Chelating Contrast Media - chemical synthesis Contrast Media - chemistry Ferric Compounds - chemistry Iron oxides Magnetic Resonance Imaging Magnetite Nanoparticles - chemistry Mice Mice, Inbred BALB C Nanoparticles Particle Size Positron emission Positron-Emission Tomography radiochemistry Strategy Surface Properties Synthesis Tomography
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Beschreibung
Zusammenfassung:	Old technique, new application: A simple and efficient chelator‐free strategy for the synthesis of a novel dual‐modality PET/MRI agent has been developed. Labeling of radioarsenic (AsIII and AsV, =71, 72, 74, 76) at the surface of superparamagnetic iron oxide nanoparticles (SPIONs) resulted in As‐SPIONs that can be used for simultaneous PET/MRI in cancer diagnosis, lymph‐node mapping, and potentially for internal radiotherapy.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201306306