Characteristics of mild dengue virus infection in Thai children
A four-year longitudinal cohort and geographic cluster study in rural Thailand was conducted to characterize the clinical spectrum of dengue virus (DENV) infection. Symptomatic DENV infections in the cohort were detected by active school absence-based surveillance that triggered cluster investigatio...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2013-12, Vol.89 (6), p.1081-1087 |
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| creator | Yoon, In-Kyu Srikiatkhachorn, Anon Hermann, Laura Buddhari, Darunee Scott, Thomas W Jarman, Richard G Aldstadt, Jared Nisalak, Ananda Thammapalo, Suwich Bhoomiboonchoo, Piraya Mammen, Mammen P Green, Sharone Gibbons, Robert V Endy, Timothy P Rothman, Alan L |
| description | A four-year longitudinal cohort and geographic cluster study in rural Thailand was conducted to characterize the clinical spectrum of dengue virus (DENV) infection. Symptomatic DENV infections in the cohort were detected by active school absence-based surveillance that triggered cluster investigations around ill cohort children. Data from 189 cohort children with symptomatic DENV infection and 126 contact children in the clusters with DENV infection were analyzed. Of infected contacts, only 19% were asymptomatic; 81% were symptomatic, but only 65.9% reported fever. Symptom-based case definitions were unreliable for diagnosis. Symptomatic infections in contacts were milder with lower DENV RNA levels than the cohort. Infections in contacts with fever history were more likely to have detectable DENV RNA than infections without fever history. Mild infections identified by cluster investigations account for a major proportion of all DENV infections. These findings are relevant for disease burden assessments, transmission modeling, and determination of vaccine impact. |
| doi_str_mv | 10.4269/ajtmh.13-0424 |
| format | Article |
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Symptomatic DENV infections in the cohort were detected by active school absence-based surveillance that triggered cluster investigations around ill cohort children. Data from 189 cohort children with symptomatic DENV infection and 126 contact children in the clusters with DENV infection were analyzed. Of infected contacts, only 19% were asymptomatic; 81% were symptomatic, but only 65.9% reported fever. Symptom-based case definitions were unreliable for diagnosis. Symptomatic infections in contacts were milder with lower DENV RNA levels than the cohort. Infections in contacts with fever history were more likely to have detectable DENV RNA than infections without fever history. Mild infections identified by cluster investigations account for a major proportion of all DENV infections. These findings are relevant for disease burden assessments, transmission modeling, and determination of vaccine impact.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.13-0424</identifier><identifier>PMID: 24127167</identifier><language>eng</language><publisher>United States: The American Society of Tropical Medicine and Hygiene</publisher><subject>Adolescent ; Child ; Child, Preschool ; Cluster Analysis ; Cohort Studies ; Dengue - epidemiology ; Dengue - transmission ; Dengue - virology ; Dengue virus ; Dengue Virus - genetics ; Dengue Virus - isolation & purification ; Female ; Fever ; Humans ; Infant ; Longitudinal Studies ; Male ; RNA, Viral - blood ; Rural Population ; Thailand - epidemiology</subject><ispartof>The American journal of tropical medicine and hygiene, 2013-12, Vol.89 (6), p.1081-1087</ispartof><rights>The American Society of Tropical Medicine and Hygiene 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-92b1e8b5e138dec5eb0ec9bce378f7a0c9e3fdabc23b7325dfc58a9d79099e763</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854884/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854884/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,724,777,781,882,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24127167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoon, In-Kyu</creatorcontrib><creatorcontrib>Srikiatkhachorn, Anon</creatorcontrib><creatorcontrib>Hermann, Laura</creatorcontrib><creatorcontrib>Buddhari, Darunee</creatorcontrib><creatorcontrib>Scott, Thomas W</creatorcontrib><creatorcontrib>Jarman, Richard G</creatorcontrib><creatorcontrib>Aldstadt, Jared</creatorcontrib><creatorcontrib>Nisalak, Ananda</creatorcontrib><creatorcontrib>Thammapalo, Suwich</creatorcontrib><creatorcontrib>Bhoomiboonchoo, Piraya</creatorcontrib><creatorcontrib>Mammen, Mammen P</creatorcontrib><creatorcontrib>Green, Sharone</creatorcontrib><creatorcontrib>Gibbons, Robert V</creatorcontrib><creatorcontrib>Endy, Timothy P</creatorcontrib><creatorcontrib>Rothman, Alan L</creatorcontrib><title>Characteristics of mild dengue virus infection in Thai children</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>A four-year longitudinal cohort and geographic cluster study in rural Thailand was conducted to characterize the clinical spectrum of dengue virus (DENV) infection. Symptomatic DENV infections in the cohort were detected by active school absence-based surveillance that triggered cluster investigations around ill cohort children. Data from 189 cohort children with symptomatic DENV infection and 126 contact children in the clusters with DENV infection were analyzed. Of infected contacts, only 19% were asymptomatic; 81% were symptomatic, but only 65.9% reported fever. Symptom-based case definitions were unreliable for diagnosis. Symptomatic infections in contacts were milder with lower DENV RNA levels than the cohort. Infections in contacts with fever history were more likely to have detectable DENV RNA than infections without fever history. Mild infections identified by cluster investigations account for a major proportion of all DENV infections. These findings are relevant for disease burden assessments, transmission modeling, and determination of vaccine impact.</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cluster Analysis</subject><subject>Cohort Studies</subject><subject>Dengue - epidemiology</subject><subject>Dengue - transmission</subject><subject>Dengue - virology</subject><subject>Dengue virus</subject><subject>Dengue Virus - genetics</subject><subject>Dengue Virus - isolation & purification</subject><subject>Female</subject><subject>Fever</subject><subject>Humans</subject><subject>Infant</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>RNA, Viral - blood</subject><subject>Rural Population</subject><subject>Thailand - epidemiology</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctLw0AQhxdRbK0evUqOXlL3lX1cFCm-oOClnpfNZtJsyUN3E8H_3tRW0ZOnGZiPHzPzIXRO8JxToa_spm-qOWEp5pQfoCnhUqRE8OwQTTHGNNWCyQk6iXGDMVGUkGM0oZxQSYScoptFZYN1PQQfe-9i0pVJ4-siKaBdD5C8-zDExLcluN537dglq8r6xFUjFKA9RUelrSOc7esMvdzfrRaP6fL54Wlxu0wdp7hPNc0JqDwDwlQBLoMcg9O5AyZVKS12GlhZ2NxRlktGs6J0mbK6kBprDVKwGbre5b4OeQOFg7YPtjavwTc2fJjOevN30vrKrLt3w1TGleJjwOU-IHRvA8TeND46qGvbQjdEM75MYsqIIP-jXGRKCI63a6U71IUuxgDlz0YEm60f8-XHEGa2fkb-4vcZP_S3EPYJEHKN8g</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Yoon, In-Kyu</creator><creator>Srikiatkhachorn, Anon</creator><creator>Hermann, Laura</creator><creator>Buddhari, Darunee</creator><creator>Scott, Thomas W</creator><creator>Jarman, Richard G</creator><creator>Aldstadt, Jared</creator><creator>Nisalak, Ananda</creator><creator>Thammapalo, Suwich</creator><creator>Bhoomiboonchoo, Piraya</creator><creator>Mammen, Mammen P</creator><creator>Green, Sharone</creator><creator>Gibbons, Robert V</creator><creator>Endy, Timothy P</creator><creator>Rothman, Alan L</creator><general>The American Society of Tropical Medicine and Hygiene</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>7T2</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>L.G</scope><scope>M7N</scope><scope>5PM</scope></search><sort><creationdate>20131201</creationdate><title>Characteristics of mild dengue virus infection in Thai children</title><author>Yoon, In-Kyu ; 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Child Child, Preschool Cluster Analysis Cohort Studies Dengue - epidemiology Dengue - transmission Dengue - virology Dengue virus Dengue Virus - genetics Dengue Virus - isolation & purification Female Fever Humans Infant Longitudinal Studies Male RNA, Viral - blood Rural Population Thailand - epidemiology |
| title | Characteristics of mild dengue virus infection in Thai children |
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