Obstructive jaundice due to ampullary metastasis of renal cell carcinoma
Renal cell carcinoma is often characterized by the presence of metachronous metastases in unusual sites. The presence of isolated metastases is treated with surgical excision with good anticipated results. On the other hand, systemic chemotherapy is administered in the context of metastatic spread,...
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| Veröffentlicht in: | World journal of surgical oncology 2013-10, Vol.11 (1), p.262-262 |
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| container_title | World journal of surgical oncology |
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| creator | Karakatsanis, Andreas Vezakis, Antonios Fragulidis, Georgios Staikou, Chryssa Carvounis, Eleni E Polydorou, Andreas |
| description | Renal cell carcinoma is often characterized by the presence of metachronous metastases in unusual sites. The presence of isolated metastases is treated with surgical excision with good anticipated results. On the other hand, systemic chemotherapy is administered in the context of metastatic spread, usually sunitib or sorafenib. In such cases, however, the presence of symptomatic foci calls for minimal intervention.We present a case of a 77-year-old patient who presented with obstructive jaundice due to an ampullary mass. Endoscopic excision and biopsy set the diagnosis of metastatic renal cell carcinoma. Consequently, imaging studies revealed the presence of multiple foci in the lungs and bone. Therefore, pancreatoduodenectomy was excluded and the patient underwent endoscopic ampullectomy and was set to oral sunitinib. Interestingly, despite generalized spread, local control was achieved until the patient succumbed to carcinomatosis.Painless obstructive jaundice in a patient with history of renal cancer and negative computed tomography scanning for pancreatic or other causes of obstruction should alert for prompt investigation for an ampullary metastasis. |
| doi_str_mv | 10.1186/1477-7819-11-262 |
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The presence of isolated metastases is treated with surgical excision with good anticipated results. On the other hand, systemic chemotherapy is administered in the context of metastatic spread, usually sunitib or sorafenib. In such cases, however, the presence of symptomatic foci calls for minimal intervention.We present a case of a 77-year-old patient who presented with obstructive jaundice due to an ampullary mass. Endoscopic excision and biopsy set the diagnosis of metastatic renal cell carcinoma. Consequently, imaging studies revealed the presence of multiple foci in the lungs and bone. Therefore, pancreatoduodenectomy was excluded and the patient underwent endoscopic ampullectomy and was set to oral sunitinib. Interestingly, despite generalized spread, local control was achieved until the patient succumbed to carcinomatosis.Painless obstructive jaundice in a patient with history of renal cancer and negative computed tomography scanning for pancreatic or other causes of obstruction should alert for prompt investigation for an ampullary metastasis.</description><identifier>ISSN: 1477-7819</identifier><identifier>EISSN: 1477-7819</identifier><identifier>DOI: 10.1186/1477-7819-11-262</identifier><identifier>PMID: 24099455</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Aged ; Ampulla of Vater - pathology ; Carcinoma, Renal cell ; Carcinoma, Renal Cell - secondary ; Care and treatment ; Case Report ; Case studies ; Common Bile Duct Neoplasms - secondary ; Complications and side effects ; Genetic aspects ; Humans ; Jaundice ; Jaundice, Obstructive - etiology ; Jaundice, Obstructive - pathology ; Kidney Neoplasms - pathology ; Male ; Metastasis ; Prognosis ; Risk factors</subject><ispartof>World journal of surgical oncology, 2013-10, Vol.11 (1), p.262-262</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Karakatsanis et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Karakatsanis et al.; licensee BioMed Central Ltd. 2013 Karakatsanis et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b582t-f11b7c1aed35e0e1578d83d735af78bb80e9f8c83dc640ffa108f8826e1f60433</citedby><cites>FETCH-LOGICAL-b582t-f11b7c1aed35e0e1578d83d735af78bb80e9f8c83dc640ffa108f8826e1f60433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854763/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3854763/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24099455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Karakatsanis, Andreas</creatorcontrib><creatorcontrib>Vezakis, Antonios</creatorcontrib><creatorcontrib>Fragulidis, Georgios</creatorcontrib><creatorcontrib>Staikou, Chryssa</creatorcontrib><creatorcontrib>Carvounis, Eleni E</creatorcontrib><creatorcontrib>Polydorou, Andreas</creatorcontrib><title>Obstructive jaundice due to ampullary metastasis of renal cell carcinoma</title><title>World journal of surgical oncology</title><addtitle>World J Surg Oncol</addtitle><description>Renal cell carcinoma is often characterized by the presence of metachronous metastases in unusual sites. The presence of isolated metastases is treated with surgical excision with good anticipated results. On the other hand, systemic chemotherapy is administered in the context of metastatic spread, usually sunitib or sorafenib. In such cases, however, the presence of symptomatic foci calls for minimal intervention.We present a case of a 77-year-old patient who presented with obstructive jaundice due to an ampullary mass. Endoscopic excision and biopsy set the diagnosis of metastatic renal cell carcinoma. Consequently, imaging studies revealed the presence of multiple foci in the lungs and bone. Therefore, pancreatoduodenectomy was excluded and the patient underwent endoscopic ampullectomy and was set to oral sunitinib. Interestingly, despite generalized spread, local control was achieved until the patient succumbed to carcinomatosis.Painless obstructive jaundice in a patient with history of renal cancer and negative computed tomography scanning for pancreatic or other causes of obstruction should alert for prompt investigation for an ampullary metastasis.</description><subject>Aged</subject><subject>Ampulla of Vater - pathology</subject><subject>Carcinoma, Renal cell</subject><subject>Carcinoma, Renal Cell - secondary</subject><subject>Care and treatment</subject><subject>Case Report</subject><subject>Case studies</subject><subject>Common Bile Duct Neoplasms - secondary</subject><subject>Complications and side effects</subject><subject>Genetic aspects</subject><subject>Humans</subject><subject>Jaundice</subject><subject>Jaundice, Obstructive - etiology</subject><subject>Jaundice, Obstructive - pathology</subject><subject>Kidney Neoplasms - pathology</subject><subject>Male</subject><subject>Metastasis</subject><subject>Prognosis</subject><subject>Risk factors</subject><issn>1477-7819</issn><issn>1477-7819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1ks9rHCEUx4fS0qRp7z2VgULpZRIdx9G5FMLSNoVALs1ZHOeZdXF0649A_vs6bLLdLQmKynuf9_Xx1ar6iNE5xry_wB1jDeN4aDBu2r59VZ3uQ68PzifVuxg3CLWEUPK2Omk7NAwdpafV1c0YU8gqmXuoNzK7ySiopwx18rWct9laGR7qGZKMZZpYe10HcNLWCmxZZFDG-Vm-r95oaSN8eNzPqtsf33-vrprrm5-_VpfXzUh5mxqN8cgUljARCggwZXziZGKESs34OHIEg-aqhFTfIa0lRlxz3vaAdY86Qs6qbzvdbR5nmBS4FKQV22Dm0qjw0ojjjDNrcefvBeG0Y_0isNoJjMa_IHCcUX4Wi5NicVJgLIrRReXrYxvB_8kQk5hNXByRDnyOpYAOmCLMWUE__4dufA7FwYXqCtOilv-j7qQFYZz25XK1iIpLSrq-ZwNbqPNnqDImmI3yDrQp8aOCLwcFa5A2raO3ORnv4jGIdqAKPsYAeu8IRmL5bM958OnwKfYFT7-L_AVYT85K</recordid><startdate>20131007</startdate><enddate>20131007</enddate><creator>Karakatsanis, Andreas</creator><creator>Vezakis, Antonios</creator><creator>Fragulidis, Georgios</creator><creator>Staikou, Chryssa</creator><creator>Carvounis, Eleni E</creator><creator>Polydorou, Andreas</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20131007</creationdate><title>Obstructive jaundice due to ampullary metastasis of renal cell carcinoma</title><author>Karakatsanis, Andreas ; Vezakis, Antonios ; Fragulidis, Georgios ; Staikou, Chryssa ; Carvounis, Eleni E ; Polydorou, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b582t-f11b7c1aed35e0e1578d83d735af78bb80e9f8c83dc640ffa108f8826e1f60433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Ampulla of Vater - pathology</topic><topic>Carcinoma, Renal cell</topic><topic>Carcinoma, Renal Cell - secondary</topic><topic>Care and treatment</topic><topic>Case Report</topic><topic>Case studies</topic><topic>Common Bile Duct Neoplasms - secondary</topic><topic>Complications and side effects</topic><topic>Genetic aspects</topic><topic>Humans</topic><topic>Jaundice</topic><topic>Jaundice, Obstructive - etiology</topic><topic>Jaundice, Obstructive - pathology</topic><topic>Kidney Neoplasms - pathology</topic><topic>Male</topic><topic>Metastasis</topic><topic>Prognosis</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Karakatsanis, Andreas</creatorcontrib><creatorcontrib>Vezakis, Antonios</creatorcontrib><creatorcontrib>Fragulidis, Georgios</creatorcontrib><creatorcontrib>Staikou, Chryssa</creatorcontrib><creatorcontrib>Carvounis, Eleni E</creatorcontrib><creatorcontrib>Polydorou, Andreas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Karakatsanis, Andreas</au><au>Vezakis, Antonios</au><au>Fragulidis, Georgios</au><au>Staikou, Chryssa</au><au>Carvounis, Eleni E</au><au>Polydorou, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obstructive jaundice due to ampullary metastasis of renal cell carcinoma</atitle><jtitle>World journal of surgical oncology</jtitle><addtitle>World J Surg Oncol</addtitle><date>2013-10-07</date><risdate>2013</risdate><volume>11</volume><issue>1</issue><spage>262</spage><epage>262</epage><pages>262-262</pages><issn>1477-7819</issn><eissn>1477-7819</eissn><abstract>Renal cell carcinoma is often characterized by the presence of metachronous metastases in unusual sites. The presence of isolated metastases is treated with surgical excision with good anticipated results. On the other hand, systemic chemotherapy is administered in the context of metastatic spread, usually sunitib or sorafenib. In such cases, however, the presence of symptomatic foci calls for minimal intervention.We present a case of a 77-year-old patient who presented with obstructive jaundice due to an ampullary mass. Endoscopic excision and biopsy set the diagnosis of metastatic renal cell carcinoma. Consequently, imaging studies revealed the presence of multiple foci in the lungs and bone. Therefore, pancreatoduodenectomy was excluded and the patient underwent endoscopic ampullectomy and was set to oral sunitinib. Interestingly, despite generalized spread, local control was achieved until the patient succumbed to carcinomatosis.Painless obstructive jaundice in a patient with history of renal cancer and negative computed tomography scanning for pancreatic or other causes of obstruction should alert for prompt investigation for an ampullary metastasis.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>24099455</pmid><doi>10.1186/1477-7819-11-262</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Ampulla of Vater - pathology Carcinoma, Renal cell Carcinoma, Renal Cell - secondary Care and treatment Case Report Case studies Common Bile Duct Neoplasms - secondary Complications and side effects Genetic aspects Humans Jaundice Jaundice, Obstructive - etiology Jaundice, Obstructive - pathology Kidney Neoplasms - pathology Male Metastasis Prognosis Risk factors |
| title | Obstructive jaundice due to ampullary metastasis of renal cell carcinoma |
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