A possible case of natalizumab-dependent suicide attempt: A brief review about drugs and suicide
β-Interferon therapy is known to be a potential trigger of suicidal behavior, but this effect has not been previously reported for other multiple sclerosis (MS) treatments, such as, natalizumab. Here we report the case history of a 32-year-old woman affected by relapsing-remitting MS, who attempted...
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| Veröffentlicht in: | Journal of pharmacology & pharmacotherapeutics 2013-12, Vol.4 (Suppl 1), p.S90-S93 |
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| container_title | Journal of pharmacology & pharmacotherapeutics |
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| creator | Mumoli, Laura Ciriaco, Miriam Gambardella, Antonio Bombardiere, Giuseppe Nicodemo Valentino, Paola Palleria, Caterina Labate, Angelo Russo, Emilio |
| description | β-Interferon therapy is known to be a potential trigger of suicidal behavior, but this effect has not been previously reported for other multiple sclerosis (MS) treatments, such as, natalizumab. Here we report the case history of a 32-year-old woman affected by relapsing-remitting MS, who attempted suicide during natalizumab treatment. This case suggests that a suicidal ideation might be a rare side effect of natalizumab. Nevertheless, this case represents the first evidence of the new adverse drug reaction related to natalizumab treatment. We should alert clinicians to be aware of the possibility of paradoxical activation of suicidality during its therapeutic use. The main purpose of the present article is to use this case to review the possible relationship between suicidal behavior and drugs. |
| doi_str_mv | 10.4103/0976-500X.120974 |
| format | Article |
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Here we report the case history of a 32-year-old woman affected by relapsing-remitting MS, who attempted suicide during natalizumab treatment. This case suggests that a suicidal ideation might be a rare side effect of natalizumab. Nevertheless, this case represents the first evidence of the new adverse drug reaction related to natalizumab treatment. We should alert clinicians to be aware of the possibility of paradoxical activation of suicidality during its therapeutic use. The main purpose of the present article is to use this case to review the possible relationship between suicidal behavior and drugs.</description><identifier>ISSN: 0976-500X</identifier><identifier>EISSN: 0976-5018</identifier><identifier>DOI: 10.4103/0976-500X.120974</identifier><identifier>PMID: 24347991</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. 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| source | Sage Journals GOLD Open Access 2024; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Addictive behaviors Care and treatment Case Review Case studies Emotional disorders Inventory Multiple sclerosis NMR Nuclear magnetic resonance Patients Risk factors Self destructive behavior Studies Substance abuse treatment Suicidal behavior Suicides & suicide attempts |
| title | A possible case of natalizumab-dependent suicide attempt: A brief review about drugs and suicide |
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