Identifying the translational gap in the evaluation of drug‐induced QTc interval prolongation

Aims Given the similarities in QTc response between dogs and humans, dogs are used in pre‐clinical cardiovascular safety studies. The objective of our investigation was to characterize the PKPD relationships and identify translational gaps across species following the administration of three compoun...

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Veröffentlicht in:	British journal of clinical pharmacology 2013-11, Vol.76 (5), p.708-724
Hauptverfasser:	Chain, Anne S.Y., Dubois, Vincent F.S., Danhof, Meindert, Sturkenboom, Miriam C.J.M., Della Pasqua, Oscar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Animals Aza Compounds - adverse effects Aza Compounds - pharmacokinetics Bayes Theorem Cisapride - adverse effects Cisapride - pharmacokinetics Cross-Over Studies Dogs Double-Blind Method Drug Evaluation, Preclinical Female Fluoroquinolones Humans Long QT Syndrome - chemically induced Male Middle Aged Models, Biological model‐based drug development Moxifloxacin pre‐clinical studies Probability QTc interval prolongation Quinolines - adverse effects Quinolines - pharmacokinetics Single-Blind Method Sotalol - adverse effects Sotalol - pharmacokinetics Species Specificity Translational Research Translational Research, Biomedical - methods translational science Young Adult
Online-Zugang:	Volltext
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