Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse

The integrity and function of epithelial tissues depend on the establishment and maintenance of defining characteristics of epithelial cells, cell–cell adhesion and cell polarity. Disruption of these characteristics can lead to the loss of epithelial identity through a process called epithelial to m...

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Veröffentlicht in:	Developmental biology 2013-12, Vol.384 (1), p.41-52
Hauptverfasser:	Yamben, Idella F., Rachel, Rivka A., Shatadal, Shalini, Copeland, Neal G., Jenkins, Nancy A., Warming, Soren, Griep, Anne E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cadherins Cadherins - genetics Cadherins - metabolism Cell Adhesion Cell polarity cornea epithelial cells Epithelial Cells - cytology Epithelial Cells - metabolism Epithelial to mesenchymal transition Epithelial-Mesenchymal Transition - genetics epithelium fibrosis gene expression regulation genes head Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism invertebrates Lens development Lens, Crystalline - metabolism Mice Mice, Transgenic PDZ proteins repressor proteins Scrib transforming growth factor beta Transforming Growth Factor beta - metabolism
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