HCS-Neurons: identifying phenotypic changes in multi-neuron images upon drug treatments of high-content screening

High-content screening (HCS) has become a powerful tool for drug discovery. However, the discovery of drugs targeting neurons is still hampered by the inability to accurately identify and quantify the phenotypic changes of multiple neurons in a single image (named multi-neuron image) of a high-conte...

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Veröffentlicht in:	BMC bioinformatics 2013-10, Vol.14 Suppl 16 (S16), p.S12-S12, Article S12
Hauptverfasser:	Charoenkwan, Phasit, Hwang, Eric, Cutler, Robert W, Lee, Hua-Chin, Ko, Li-Wei, Huang, Hui-Ling, Ho, Shinn-Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Automatic Data Processing Automation Axons Bioengineering Cell culture Cell Line Classification Genetic algorithms High-Throughput Screening Assays Image Processing, Computer-Assisted - methods Mice Neurites - drug effects Neurons Neurons - cytology Neurons - drug effects Nocodazole - pharmacology Phenotype Regression Analysis Science Studies Support Vector Machine
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