Behavioral and clinical correlates of serum bilirubin concentrations in Japanese men and women
A considerable interest has been drawn to potential protective effects of bilirubin against oxidative stress-related diseases. Smoking is known to be associated with lower concentrations of serum bilirubin, but other behavioral correlates of serum bilirubin have not been well studied. In this cross-...
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| Veröffentlicht in: | BMC endocrine disorders 2013-10, Vol.13 (1), p.39-39, Article 39 |
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| creator | Tanaka, Maya Budhathoki, Sanjeev Hirata, Akie Morita, Makiko Kono, Suminori Adachi, Masahiro Kawate, Hisaya Ohnaka, Keizo Takayanagi, Ryoichi |
| description | A considerable interest has been drawn to potential protective effects of bilirubin against oxidative stress-related diseases. Smoking is known to be associated with lower concentrations of serum bilirubin, but other behavioral correlates of serum bilirubin have not been well studied. In this cross-sectional study, we examined the associations of behavioral and clinical factors with serum total bilirubin in Japanese men and women.
The study subjects comprised of 4802 men and 6414 women aged 49-76 years who participated in the baseline survey of an ongoing cohort study on lifestyle-related diseases in Fukuoka, Japan. With consideration to time of the day of blood sampling and fasting hours, the associations with smoking, alcohol intake, body mass index, physical activity, coffee, tea, blood pressure, glycated hemoglobin (HbA1c), HDL cholesterol and non-HDL cholesterol with serum bilirubin were evaluated by analysis of covariance and multiple linear regression analysis.
While smoking was negatively associated with serum bilirubin, alcohol consumption was positively associated with serum bilirubin in both men and women. Coffee consumption was associated with lower bilirubin concentrations in both sexes. In the multiple linear regression analysis, HDL cholesterol was positively and HbA1c was negatively associated with bilirubin in both men and women, and the associations were more evident in women.
Smoking, alcohol use and coffee consumption were important behavioral correlates of serum bilirubin in Japanese men and women. Serum HDL cholesterol was a measurable clinical correlate of bilirubin in women. |
| doi_str_mv | 10.1186/1472-6823-13-39 |
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The study subjects comprised of 4802 men and 6414 women aged 49-76 years who participated in the baseline survey of an ongoing cohort study on lifestyle-related diseases in Fukuoka, Japan. With consideration to time of the day of blood sampling and fasting hours, the associations with smoking, alcohol intake, body mass index, physical activity, coffee, tea, blood pressure, glycated hemoglobin (HbA1c), HDL cholesterol and non-HDL cholesterol with serum bilirubin were evaluated by analysis of covariance and multiple linear regression analysis.
While smoking was negatively associated with serum bilirubin, alcohol consumption was positively associated with serum bilirubin in both men and women. Coffee consumption was associated with lower bilirubin concentrations in both sexes. In the multiple linear regression analysis, HDL cholesterol was positively and HbA1c was negatively associated with bilirubin in both men and women, and the associations were more evident in women.
Smoking, alcohol use and coffee consumption were important behavioral correlates of serum bilirubin in Japanese men and women. Serum HDL cholesterol was a measurable clinical correlate of bilirubin in women.</description><identifier>ISSN: 1472-6823</identifier><identifier>EISSN: 1472-6823</identifier><identifier>DOI: 10.1186/1472-6823-13-39</identifier><identifier>PMID: 24090309</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Bilirubin ; Blood ; Blood cholesterol ; Body mass index ; Cardiovascular disease ; Cholesterol ; Coffee ; Exercise ; Glycosylated hemoglobin ; Health behavior ; Measurement ; Medical examination ; Medical research ; Medicine, Experimental ; Oxidative stress ; Physiological aspects ; Risk factors ; Studies ; Womens health</subject><ispartof>BMC endocrine disorders, 2013-10, Vol.13 (1), p.39-39, Article 39</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Tanaka et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Tanaka et al.; licensee BioMed Central Ltd. 2013 Tanaka et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b613t-f6342383639b85dcfeec4df025410a34550c1b2c6cf9c7bd5cdb35e94d786fe43</citedby><cites>FETCH-LOGICAL-b613t-f6342383639b85dcfeec4df025410a34550c1b2c6cf9c7bd5cdb35e94d786fe43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852517/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852517/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24090309$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Maya</creatorcontrib><creatorcontrib>Budhathoki, Sanjeev</creatorcontrib><creatorcontrib>Hirata, Akie</creatorcontrib><creatorcontrib>Morita, Makiko</creatorcontrib><creatorcontrib>Kono, Suminori</creatorcontrib><creatorcontrib>Adachi, Masahiro</creatorcontrib><creatorcontrib>Kawate, Hisaya</creatorcontrib><creatorcontrib>Ohnaka, Keizo</creatorcontrib><creatorcontrib>Takayanagi, Ryoichi</creatorcontrib><title>Behavioral and clinical correlates of serum bilirubin concentrations in Japanese men and women</title><title>BMC endocrine disorders</title><addtitle>BMC Endocr Disord</addtitle><description>A considerable interest has been drawn to potential protective effects of bilirubin against oxidative stress-related diseases. Smoking is known to be associated with lower concentrations of serum bilirubin, but other behavioral correlates of serum bilirubin have not been well studied. In this cross-sectional study, we examined the associations of behavioral and clinical factors with serum total bilirubin in Japanese men and women.
The study subjects comprised of 4802 men and 6414 women aged 49-76 years who participated in the baseline survey of an ongoing cohort study on lifestyle-related diseases in Fukuoka, Japan. With consideration to time of the day of blood sampling and fasting hours, the associations with smoking, alcohol intake, body mass index, physical activity, coffee, tea, blood pressure, glycated hemoglobin (HbA1c), HDL cholesterol and non-HDL cholesterol with serum bilirubin were evaluated by analysis of covariance and multiple linear regression analysis.
While smoking was negatively associated with serum bilirubin, alcohol consumption was positively associated with serum bilirubin in both men and women. Coffee consumption was associated with lower bilirubin concentrations in both sexes. In the multiple linear regression analysis, HDL cholesterol was positively and HbA1c was negatively associated with bilirubin in both men and women, and the associations were more evident in women.
Smoking, alcohol use and coffee consumption were important behavioral correlates of serum bilirubin in Japanese men and women. Serum HDL cholesterol was a measurable clinical correlate of bilirubin in women.</description><subject>Bilirubin</subject><subject>Blood</subject><subject>Blood cholesterol</subject><subject>Body mass index</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Coffee</subject><subject>Exercise</subject><subject>Glycosylated hemoglobin</subject><subject>Health behavior</subject><subject>Measurement</subject><subject>Medical examination</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Oxidative stress</subject><subject>Physiological aspects</subject><subject>Risk factors</subject><subject>Studies</subject><subject>Womens health</subject><issn>1472-6823</issn><issn>1472-6823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1ks9vFSEQx4mxsfXp2ZvZxIuXbYGB_XExaZuqbZp40auEZYeWZheesNvG_76sr772mRoOwMx3PjBfIOQdo4eMNdUREzUvq4ZDyaCE9gU52EZePlnvk9cp3VDK6obTV2SfC9pSoO0B-XmC1_rWhaiHQvu-MIPzzuSNCTHioCdMRbBFwjiPRecGF-fO-Zz1Bv0U9eSCT0WOXOi19piwGNH_Id2FvHpD9qweEr59mFfkx-ez76dfy8tvX85Pjy_LrmIwlbYCwaGBCtqukb2xiEb0lnIpGNUgpKSGddxUxram7npp-g4ktqKvm8qigBX5tOGu527EfnO3Qa2jG3X8rYJ2ajfj3bW6CrcKGsklqzPgZAPoXPgPYDdjwqgWf9Xir2KgoM2Qjw-3iOHXjGlSo0sGhyE7E-aU9bJlUla55xX58I_0JszRZ4-ySvBGZLZ4VF3pAZXzNuSzzQJVxxJEBZLCwjp8RpVHj6PLL4XW5fhOwdGmwMSQUkS77ZNRtfyrZzp7_9Tfrf7vR4J7GhjIqQ</recordid><startdate>20131004</startdate><enddate>20131004</enddate><creator>Tanaka, Maya</creator><creator>Budhathoki, Sanjeev</creator><creator>Hirata, Akie</creator><creator>Morita, Makiko</creator><creator>Kono, Suminori</creator><creator>Adachi, Masahiro</creator><creator>Kawate, Hisaya</creator><creator>Ohnaka, Keizo</creator><creator>Takayanagi, Ryoichi</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20131004</creationdate><title>Behavioral and clinical correlates of serum bilirubin concentrations in Japanese men and women</title><author>Tanaka, Maya ; Budhathoki, Sanjeev ; Hirata, Akie ; Morita, Makiko ; Kono, Suminori ; Adachi, Masahiro ; Kawate, Hisaya ; Ohnaka, Keizo ; Takayanagi, Ryoichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b613t-f6342383639b85dcfeec4df025410a34550c1b2c6cf9c7bd5cdb35e94d786fe43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Bilirubin</topic><topic>Blood</topic><topic>Blood cholesterol</topic><topic>Body mass index</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Coffee</topic><topic>Exercise</topic><topic>Glycosylated hemoglobin</topic><topic>Health behavior</topic><topic>Measurement</topic><topic>Medical examination</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Oxidative stress</topic><topic>Physiological aspects</topic><topic>Risk factors</topic><topic>Studies</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Maya</creatorcontrib><creatorcontrib>Budhathoki, Sanjeev</creatorcontrib><creatorcontrib>Hirata, Akie</creatorcontrib><creatorcontrib>Morita, Makiko</creatorcontrib><creatorcontrib>Kono, Suminori</creatorcontrib><creatorcontrib>Adachi, Masahiro</creatorcontrib><creatorcontrib>Kawate, Hisaya</creatorcontrib><creatorcontrib>Ohnaka, Keizo</creatorcontrib><creatorcontrib>Takayanagi, Ryoichi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC endocrine disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Maya</au><au>Budhathoki, Sanjeev</au><au>Hirata, Akie</au><au>Morita, Makiko</au><au>Kono, Suminori</au><au>Adachi, Masahiro</au><au>Kawate, Hisaya</au><au>Ohnaka, Keizo</au><au>Takayanagi, Ryoichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Behavioral and clinical correlates of serum bilirubin concentrations in Japanese men and women</atitle><jtitle>BMC endocrine disorders</jtitle><addtitle>BMC Endocr Disord</addtitle><date>2013-10-04</date><risdate>2013</risdate><volume>13</volume><issue>1</issue><spage>39</spage><epage>39</epage><pages>39-39</pages><artnum>39</artnum><issn>1472-6823</issn><eissn>1472-6823</eissn><abstract>A considerable interest has been drawn to potential protective effects of bilirubin against oxidative stress-related diseases. Smoking is known to be associated with lower concentrations of serum bilirubin, but other behavioral correlates of serum bilirubin have not been well studied. In this cross-sectional study, we examined the associations of behavioral and clinical factors with serum total bilirubin in Japanese men and women.
The study subjects comprised of 4802 men and 6414 women aged 49-76 years who participated in the baseline survey of an ongoing cohort study on lifestyle-related diseases in Fukuoka, Japan. With consideration to time of the day of blood sampling and fasting hours, the associations with smoking, alcohol intake, body mass index, physical activity, coffee, tea, blood pressure, glycated hemoglobin (HbA1c), HDL cholesterol and non-HDL cholesterol with serum bilirubin were evaluated by analysis of covariance and multiple linear regression analysis.
While smoking was negatively associated with serum bilirubin, alcohol consumption was positively associated with serum bilirubin in both men and women. Coffee consumption was associated with lower bilirubin concentrations in both sexes. In the multiple linear regression analysis, HDL cholesterol was positively and HbA1c was negatively associated with bilirubin in both men and women, and the associations were more evident in women.
Smoking, alcohol use and coffee consumption were important behavioral correlates of serum bilirubin in Japanese men and women. Serum HDL cholesterol was a measurable clinical correlate of bilirubin in women.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>24090309</pmid><doi>10.1186/1472-6823-13-39</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; SpringerNature Journals; PubMed Central Open Access; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Bilirubin Blood Blood cholesterol Body mass index Cardiovascular disease Cholesterol Coffee Exercise Glycosylated hemoglobin Health behavior Measurement Medical examination Medical research Medicine, Experimental Oxidative stress Physiological aspects Risk factors Studies Womens health |
| title | Behavioral and clinical correlates of serum bilirubin concentrations in Japanese men and women |
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