Evaluating human cancer cell metastasis in zebrafish

In vivo metastasis assays have traditionally been performed in mice, but the process is inefficient and costly. However, since zebrafish do not develop an adaptive immune system until 14 days post-fertilization, human cancer cells can survive and metastasize when transplanted into zebrafish larvae....

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Veröffentlicht in:	BMC cancer 2013-10, Vol.13 (1), p.453-453, Article 453
Hauptverfasser:	Teng, Yong, Xie, Xiayang, Walker, Steven, White, David T, Mumm, Jeff S, Cowell, John K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Breast cancer Cancer cells Cell Line, Tumor Danio rerio Development and progression Disease Models, Animal Disease Progression Freshwater Gene Expression Regulation, Neoplastic Genetic engineering Humans Janus Kinases - metabolism Lung cancer Male Metastasis Mice Neoplasm Grading Neoplasm Metastasis Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Phenotype Physiological aspects Protein Kinases - metabolism Rodents Sarcoma Tumors Wiskott-Aldrich Syndrome Protein Family - genetics Zebra fish Zebrafish
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