Protective effects of Zhuyeqing liquor on the immune function of normal and immunosuppressed mice in vivo
Zhuyeqing Liquor (ZYQL), a well-known Chinese traditional health liquor, has various biological properties, including anti-oxidant, anti-inflammatory, immunoenhancement and cardiovascular protective effects. The protective effects of Zhuyeqing Liquor (ZYQL) on the immune function was investigated in...
Gespeichert in:
| Veröffentlicht in: | BMC complementary and alternative medicine 2013-10, Vol.13 (1), p.252-252, Article 252 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 252 |
|---|---|
| container_issue | 1 |
| container_start_page | 252 |
| container_title | BMC complementary and alternative medicine |
| container_volume | 13 |
| creator | Gao, Hong-ying Li, Guo-yu Huang, Jian Han, Ying Sun, Fu-zhou Du, Xiao-wei An, Li-juan Wang, Hang-yu Wang, Jin-hui |
| description | Zhuyeqing Liquor (ZYQL), a well-known Chinese traditional health liquor, has various biological properties, including anti-oxidant, anti-inflammatory, immunoenhancement and cardiovascular protective effects.
The protective effects of Zhuyeqing Liquor (ZYQL) on the immune function was investigated in vivo in normal healthy mice and immunosuppressed mice treated with Cyclophosphamide (Cy, 100 mg/kg) by intraperitoneal injection on days 4, 8 and 12. ZYQL (100, 200 and 400 mg/kg) was administered via gavage daily for 14 days. The phagocytotic function of mononuclear phagocytic system was detected with carbon clearance methods, the levels of interleukin-6 (IL-6) and interferon-gamma (IFN-γ) in serum were detected with Enzyme linked immunosorbent assay (ELISA). Immune organs were weighed and organ indexes (organ weight/body weight) of thymus and spleen were calculated. Meanwhile, the activity of lysozyme (LSZ) in serum and the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) in spleen tissue were measured.
ZYQL significantly upgrades the K value for clearance of carbon particles in normal mice treated with ZYQL (400 mg/kg) and immunosuppressed mice treated with ZYQL (100, 200 and 400 mg/kg) together with Cy (100 mg/kg) in vivo. The treatment of ZYQL (100, 200 and 400 mg/kg) effectively increased the activity of serum lysozyme as well as promoted the serum levels of IL-6 and IFN-γ in normal mice and immunosuppressed mice. Furthermore, ZYQL (100, 200 and 400 mg/kg) had an antioxidant effects in immune system by enhancing the antioxidant enzyme activity of SOD, CAT and GSH-Px in vivo. In addition, ZYQL (100, 200 and 400 mg/kg) effectively elevated the Cy-induced decreased organ index (thymus and spleen).
The present work shows that the dose-dependent administration of ZYQL is capable of influencing immune responses, which implying that its valuable functional health may be attributed partly to its protective effects for the immune function. |
| doi_str_mv | 10.1186/1472-6882-13-252 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3852147</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A534635006</galeid><sourcerecordid>A534635006</sourcerecordid><originalsourceid>FETCH-LOGICAL-b648t-b35be441d7d944dbe74cb6647314294edd737392c61a59ee924d79a503f20a8a3</originalsourceid><addsrcrecordid>eNqFktuL1DAUxoso7kXffZKAIPvSNfekL8IyeIMFfdAXX0Lank6ztMlM0g7sf2_KrOOMrNg8NJzz-z7Cd05RvCL4mhAt3xGuaCm1piVhJRX0SXF-KD09up8VFyndYUyUJvx5cUY5rjAX8rxw32KYoJncDhB0Xb4lFDr0s5_vYev8Gg1uO4eIgkdTD8iN4-wBdbPPklzLqA9xtAOyvt13Q5o3mwgpQYtG12SNRzu3Cy-KZ50dErx8-F8WPz5--L76XN5-_fRldXNb1pLrqayZqIFz0qq24rytQfGmlpIrRjitOLStYopVtJHEigqgorxVlRWYdRRbbdll8X7vu5nrEdoG_BTtYDbRjTbem2CdOe1415t12BmmBc2JZYPV3qB24R8Gp50mjGaJ2ixRG8JMnkR2uXp4RgzbGdJkRpcaGAbrIczJUK1VpbUg-r8o4ZILQiu1oG_-Qu_CHH3OM1P504pJ_oda2wGM813I72wWU3MjGJdMYCwzdf0IlU8LeW7BQ-dy_UTw9kjQgx2mPoVhXjYhnYJ4DzYxpBShO4RHsFkW97G4Xh9P7SD4vansF7Id58Q</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1444487364</pqid></control><display><type>article</type><title>Protective effects of Zhuyeqing liquor on the immune function of normal and immunosuppressed mice in vivo</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Gao, Hong-ying ; Li, Guo-yu ; Huang, Jian ; Han, Ying ; Sun, Fu-zhou ; Du, Xiao-wei ; An, Li-juan ; Wang, Hang-yu ; Wang, Jin-hui</creator><creatorcontrib>Gao, Hong-ying ; Li, Guo-yu ; Huang, Jian ; Han, Ying ; Sun, Fu-zhou ; Du, Xiao-wei ; An, Li-juan ; Wang, Hang-yu ; Wang, Jin-hui</creatorcontrib><description>Zhuyeqing Liquor (ZYQL), a well-known Chinese traditional health liquor, has various biological properties, including anti-oxidant, anti-inflammatory, immunoenhancement and cardiovascular protective effects.
The protective effects of Zhuyeqing Liquor (ZYQL) on the immune function was investigated in vivo in normal healthy mice and immunosuppressed mice treated with Cyclophosphamide (Cy, 100 mg/kg) by intraperitoneal injection on days 4, 8 and 12. ZYQL (100, 200 and 400 mg/kg) was administered via gavage daily for 14 days. The phagocytotic function of mononuclear phagocytic system was detected with carbon clearance methods, the levels of interleukin-6 (IL-6) and interferon-gamma (IFN-γ) in serum were detected with Enzyme linked immunosorbent assay (ELISA). Immune organs were weighed and organ indexes (organ weight/body weight) of thymus and spleen were calculated. Meanwhile, the activity of lysozyme (LSZ) in serum and the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) in spleen tissue were measured.
ZYQL significantly upgrades the K value for clearance of carbon particles in normal mice treated with ZYQL (400 mg/kg) and immunosuppressed mice treated with ZYQL (100, 200 and 400 mg/kg) together with Cy (100 mg/kg) in vivo. The treatment of ZYQL (100, 200 and 400 mg/kg) effectively increased the activity of serum lysozyme as well as promoted the serum levels of IL-6 and IFN-γ in normal mice and immunosuppressed mice. Furthermore, ZYQL (100, 200 and 400 mg/kg) had an antioxidant effects in immune system by enhancing the antioxidant enzyme activity of SOD, CAT and GSH-Px in vivo. In addition, ZYQL (100, 200 and 400 mg/kg) effectively elevated the Cy-induced decreased organ index (thymus and spleen).
The present work shows that the dose-dependent administration of ZYQL is capable of influencing immune responses, which implying that its valuable functional health may be attributed partly to its protective effects for the immune function.</description><identifier>ISSN: 1472-6882</identifier><identifier>EISSN: 1472-6882</identifier><identifier>DOI: 10.1186/1472-6882-13-252</identifier><identifier>PMID: 24090456</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Analysis of Variance ; Animals ; antioxidant enzymes ; Antioxidants ; blood serum ; carbon ; Carbon - pharmacokinetics ; catalase ; complement ; cyclophosphamide ; Cytokines - blood ; dose response ; Drug dosages ; Drugs, Chinese Herbal - pharmacology ; enzyme activity ; Enzyme-linked immunosorbent assay ; Enzymes ; Experiments ; Free radicals ; glutathione peroxidase ; Health aspects ; Herbal medicine ; Immune response ; Immune system ; Immunocompromised Host ; Immunosuppression ; interferon-gamma ; interleukin-6 ; Interleukins ; intraperitoneal injection ; Liquor ; Lysozyme ; Male ; Mice ; Mice, Inbred BALB C ; Muramidase - blood ; Phagocytosis - drug effects ; Protective Agents - pharmacology ; Spleen ; Spleen - drug effects ; Spleen - enzymology ; Superoxide ; Tissue Distribution ; tissue weight</subject><ispartof>BMC complementary and alternative medicine, 2013-10, Vol.13 (1), p.252-252, Article 252</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Gao et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Gao et al.; licensee BioMed Central Ltd. 2013 Gao et al.; licensee BioMed Central Ltd.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b648t-b35be441d7d944dbe74cb6647314294edd737392c61a59ee924d79a503f20a8a3</citedby><cites>FETCH-LOGICAL-b648t-b35be441d7d944dbe74cb6647314294edd737392c61a59ee924d79a503f20a8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852147/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852147/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27907,27908,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24090456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gao, Hong-ying</creatorcontrib><creatorcontrib>Li, Guo-yu</creatorcontrib><creatorcontrib>Huang, Jian</creatorcontrib><creatorcontrib>Han, Ying</creatorcontrib><creatorcontrib>Sun, Fu-zhou</creatorcontrib><creatorcontrib>Du, Xiao-wei</creatorcontrib><creatorcontrib>An, Li-juan</creatorcontrib><creatorcontrib>Wang, Hang-yu</creatorcontrib><creatorcontrib>Wang, Jin-hui</creatorcontrib><title>Protective effects of Zhuyeqing liquor on the immune function of normal and immunosuppressed mice in vivo</title><title>BMC complementary and alternative medicine</title><addtitle>BMC Complement Altern Med</addtitle><description>Zhuyeqing Liquor (ZYQL), a well-known Chinese traditional health liquor, has various biological properties, including anti-oxidant, anti-inflammatory, immunoenhancement and cardiovascular protective effects.
The protective effects of Zhuyeqing Liquor (ZYQL) on the immune function was investigated in vivo in normal healthy mice and immunosuppressed mice treated with Cyclophosphamide (Cy, 100 mg/kg) by intraperitoneal injection on days 4, 8 and 12. ZYQL (100, 200 and 400 mg/kg) was administered via gavage daily for 14 days. The phagocytotic function of mononuclear phagocytic system was detected with carbon clearance methods, the levels of interleukin-6 (IL-6) and interferon-gamma (IFN-γ) in serum were detected with Enzyme linked immunosorbent assay (ELISA). Immune organs were weighed and organ indexes (organ weight/body weight) of thymus and spleen were calculated. Meanwhile, the activity of lysozyme (LSZ) in serum and the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) in spleen tissue were measured.
ZYQL significantly upgrades the K value for clearance of carbon particles in normal mice treated with ZYQL (400 mg/kg) and immunosuppressed mice treated with ZYQL (100, 200 and 400 mg/kg) together with Cy (100 mg/kg) in vivo. The treatment of ZYQL (100, 200 and 400 mg/kg) effectively increased the activity of serum lysozyme as well as promoted the serum levels of IL-6 and IFN-γ in normal mice and immunosuppressed mice. Furthermore, ZYQL (100, 200 and 400 mg/kg) had an antioxidant effects in immune system by enhancing the antioxidant enzyme activity of SOD, CAT and GSH-Px in vivo. In addition, ZYQL (100, 200 and 400 mg/kg) effectively elevated the Cy-induced decreased organ index (thymus and spleen).
The present work shows that the dose-dependent administration of ZYQL is capable of influencing immune responses, which implying that its valuable functional health may be attributed partly to its protective effects for the immune function.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>antioxidant enzymes</subject><subject>Antioxidants</subject><subject>blood serum</subject><subject>carbon</subject><subject>Carbon - pharmacokinetics</subject><subject>catalase</subject><subject>complement</subject><subject>cyclophosphamide</subject><subject>Cytokines - blood</subject><subject>dose response</subject><subject>Drug dosages</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>enzyme activity</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Enzymes</subject><subject>Experiments</subject><subject>Free radicals</subject><subject>glutathione peroxidase</subject><subject>Health aspects</subject><subject>Herbal medicine</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunocompromised Host</subject><subject>Immunosuppression</subject><subject>interferon-gamma</subject><subject>interleukin-6</subject><subject>Interleukins</subject><subject>intraperitoneal injection</subject><subject>Liquor</subject><subject>Lysozyme</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Muramidase - blood</subject><subject>Phagocytosis - drug effects</subject><subject>Protective Agents - pharmacology</subject><subject>Spleen</subject><subject>Spleen - drug effects</subject><subject>Spleen - enzymology</subject><subject>Superoxide</subject><subject>Tissue Distribution</subject><subject>tissue weight</subject><issn>1472-6882</issn><issn>1472-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqFktuL1DAUxoso7kXffZKAIPvSNfekL8IyeIMFfdAXX0Lank6ztMlM0g7sf2_KrOOMrNg8NJzz-z7Cd05RvCL4mhAt3xGuaCm1piVhJRX0SXF-KD09up8VFyndYUyUJvx5cUY5rjAX8rxw32KYoJncDhB0Xb4lFDr0s5_vYev8Gg1uO4eIgkdTD8iN4-wBdbPPklzLqA9xtAOyvt13Q5o3mwgpQYtG12SNRzu3Cy-KZ50dErx8-F8WPz5--L76XN5-_fRldXNb1pLrqayZqIFz0qq24rytQfGmlpIrRjitOLStYopVtJHEigqgorxVlRWYdRRbbdll8X7vu5nrEdoG_BTtYDbRjTbem2CdOe1415t12BmmBc2JZYPV3qB24R8Gp50mjGaJ2ixRG8JMnkR2uXp4RgzbGdJkRpcaGAbrIczJUK1VpbUg-r8o4ZILQiu1oG_-Qu_CHH3OM1P504pJ_oda2wGM813I72wWU3MjGJdMYCwzdf0IlU8LeW7BQ-dy_UTw9kjQgx2mPoVhXjYhnYJ4DzYxpBShO4RHsFkW97G4Xh9P7SD4vansF7Id58Q</recordid><startdate>20131003</startdate><enddate>20131003</enddate><creator>Gao, Hong-ying</creator><creator>Li, Guo-yu</creator><creator>Huang, Jian</creator><creator>Han, Ying</creator><creator>Sun, Fu-zhou</creator><creator>Du, Xiao-wei</creator><creator>An, Li-juan</creator><creator>Wang, Hang-yu</creator><creator>Wang, Jin-hui</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7T5</scope><scope>H94</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20131003</creationdate><title>Protective effects of Zhuyeqing liquor on the immune function of normal and immunosuppressed mice in vivo</title><author>Gao, Hong-ying ; Li, Guo-yu ; Huang, Jian ; Han, Ying ; Sun, Fu-zhou ; Du, Xiao-wei ; An, Li-juan ; Wang, Hang-yu ; Wang, Jin-hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b648t-b35be441d7d944dbe74cb6647314294edd737392c61a59ee924d79a503f20a8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>antioxidant enzymes</topic><topic>Antioxidants</topic><topic>blood serum</topic><topic>carbon</topic><topic>Carbon - pharmacokinetics</topic><topic>catalase</topic><topic>complement</topic><topic>cyclophosphamide</topic><topic>Cytokines - blood</topic><topic>dose response</topic><topic>Drug dosages</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>enzyme activity</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Enzymes</topic><topic>Experiments</topic><topic>Free radicals</topic><topic>glutathione peroxidase</topic><topic>Health aspects</topic><topic>Herbal medicine</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunocompromised Host</topic><topic>Immunosuppression</topic><topic>interferon-gamma</topic><topic>interleukin-6</topic><topic>Interleukins</topic><topic>intraperitoneal injection</topic><topic>Liquor</topic><topic>Lysozyme</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Muramidase - blood</topic><topic>Phagocytosis - drug effects</topic><topic>Protective Agents - pharmacology</topic><topic>Spleen</topic><topic>Spleen - drug effects</topic><topic>Spleen - enzymology</topic><topic>Superoxide</topic><topic>Tissue Distribution</topic><topic>tissue weight</topic><toplevel>online_resources</toplevel><creatorcontrib>Gao, Hong-ying</creatorcontrib><creatorcontrib>Li, Guo-yu</creatorcontrib><creatorcontrib>Huang, Jian</creatorcontrib><creatorcontrib>Han, Ying</creatorcontrib><creatorcontrib>Sun, Fu-zhou</creatorcontrib><creatorcontrib>Du, Xiao-wei</creatorcontrib><creatorcontrib>An, Li-juan</creatorcontrib><creatorcontrib>Wang, Hang-yu</creatorcontrib><creatorcontrib>Wang, Jin-hui</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gao, Hong-ying</au><au>Li, Guo-yu</au><au>Huang, Jian</au><au>Han, Ying</au><au>Sun, Fu-zhou</au><au>Du, Xiao-wei</au><au>An, Li-juan</au><au>Wang, Hang-yu</au><au>Wang, Jin-hui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of Zhuyeqing liquor on the immune function of normal and immunosuppressed mice in vivo</atitle><jtitle>BMC complementary and alternative medicine</jtitle><addtitle>BMC Complement Altern Med</addtitle><date>2013-10-03</date><risdate>2013</risdate><volume>13</volume><issue>1</issue><spage>252</spage><epage>252</epage><pages>252-252</pages><artnum>252</artnum><issn>1472-6882</issn><eissn>1472-6882</eissn><abstract>Zhuyeqing Liquor (ZYQL), a well-known Chinese traditional health liquor, has various biological properties, including anti-oxidant, anti-inflammatory, immunoenhancement and cardiovascular protective effects.
The protective effects of Zhuyeqing Liquor (ZYQL) on the immune function was investigated in vivo in normal healthy mice and immunosuppressed mice treated with Cyclophosphamide (Cy, 100 mg/kg) by intraperitoneal injection on days 4, 8 and 12. ZYQL (100, 200 and 400 mg/kg) was administered via gavage daily for 14 days. The phagocytotic function of mononuclear phagocytic system was detected with carbon clearance methods, the levels of interleukin-6 (IL-6) and interferon-gamma (IFN-γ) in serum were detected with Enzyme linked immunosorbent assay (ELISA). Immune organs were weighed and organ indexes (organ weight/body weight) of thymus and spleen were calculated. Meanwhile, the activity of lysozyme (LSZ) in serum and the activity of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT) in spleen tissue were measured.
ZYQL significantly upgrades the K value for clearance of carbon particles in normal mice treated with ZYQL (400 mg/kg) and immunosuppressed mice treated with ZYQL (100, 200 and 400 mg/kg) together with Cy (100 mg/kg) in vivo. The treatment of ZYQL (100, 200 and 400 mg/kg) effectively increased the activity of serum lysozyme as well as promoted the serum levels of IL-6 and IFN-γ in normal mice and immunosuppressed mice. Furthermore, ZYQL (100, 200 and 400 mg/kg) had an antioxidant effects in immune system by enhancing the antioxidant enzyme activity of SOD, CAT and GSH-Px in vivo. In addition, ZYQL (100, 200 and 400 mg/kg) effectively elevated the Cy-induced decreased organ index (thymus and spleen).
The present work shows that the dose-dependent administration of ZYQL is capable of influencing immune responses, which implying that its valuable functional health may be attributed partly to its protective effects for the immune function.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>24090456</pmid><doi>10.1186/1472-6882-13-252</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1472-6882 |
| ispartof | BMC complementary and alternative medicine, 2013-10, Vol.13 (1), p.252-252, Article 252 |
| issn | 1472-6882 1472-6882 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3852147 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; PubMed Central |
| subjects | Analysis of Variance Animals antioxidant enzymes Antioxidants blood serum carbon Carbon - pharmacokinetics catalase complement cyclophosphamide Cytokines - blood dose response Drug dosages Drugs, Chinese Herbal - pharmacology enzyme activity Enzyme-linked immunosorbent assay Enzymes Experiments Free radicals glutathione peroxidase Health aspects Herbal medicine Immune response Immune system Immunocompromised Host Immunosuppression interferon-gamma interleukin-6 Interleukins intraperitoneal injection Liquor Lysozyme Male Mice Mice, Inbred BALB C Muramidase - blood Phagocytosis - drug effects Protective Agents - pharmacology Spleen Spleen - drug effects Spleen - enzymology Superoxide Tissue Distribution tissue weight |
| title | Protective effects of Zhuyeqing liquor on the immune function of normal and immunosuppressed mice in vivo |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T19%3A34%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protective%20effects%20of%20Zhuyeqing%20liquor%20on%20the%20immune%20function%20of%20normal%20and%20immunosuppressed%20mice%20in%20vivo&rft.jtitle=BMC%20complementary%20and%20alternative%20medicine&rft.au=Gao,%20Hong-ying&rft.date=2013-10-03&rft.volume=13&rft.issue=1&rft.spage=252&rft.epage=252&rft.pages=252-252&rft.artnum=252&rft.issn=1472-6882&rft.eissn=1472-6882&rft_id=info:doi/10.1186/1472-6882-13-252&rft_dat=%3Cgale_pubme%3EA534635006%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1444487364&rft_id=info:pmid/24090456&rft_galeid=A534635006&rfr_iscdi=true |