Antihistamine use and immunoglobulin E levels in glioma risk and prognosis

Abstract Objective: An inverse association between personal history of allergies/asthma and glioma risk has been fairly consistently reported in the epidemiologic literature. However, the role of regular antihistamine use remains controversial due to a small number of studies reporting contradictory...

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Veröffentlicht in:Cancer epidemiology 2013-12, Vol.37 (6), p.908-912
Hauptverfasser: Amirian, E. Susan, Marquez-Do, Deborah, Bondy, Melissa L, Scheurer, Michael E
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container_title Cancer epidemiology
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creator Amirian, E. Susan
Marquez-Do, Deborah
Bondy, Melissa L
Scheurer, Michael E
description Abstract Objective: An inverse association between personal history of allergies/asthma and glioma risk has been fairly consistently reported in the epidemiologic literature. However, the role of regular antihistamine use remains controversial due to a small number of studies reporting contradictory findings. We evaluated the association between regular use of oral antihistamines and glioma risk, adjusting for a number of relevant factors (e.g., immunoglobulin E levels and history of chickenpox). Methods : We used a subset of the Harris County Case-Control Study, which included 362 pathologically confirmed glioma cases and 462 cancer-free controls, to evaluate this association using unconditional multivariable logistic regression. These models were run among the overall study population and stratified by allergy status. Cox regression was utilized to examine whether antihistamine use was associated with mortality among all cases and separately among high-grade cases. Results : Antihistamine use was strongly associated with glioma risk among those with a positive allergy/asthma history (OR: 4.19, 95% CI: 2.06–8.51), but not among those with a negative history (OR: 1.59, 95% CI: 0.95–2.67). There were no significant associations between antihistamine use and survival among cases. Conclusion : The current study implies that regular antihistamine use may increase glioma risk. However, several larger studies are necessary before definitive conclusions can be drawn.
doi_str_mv 10.1016/j.canep.2013.08.004
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Susan ; Marquez-Do, Deborah ; Bondy, Melissa L ; Scheurer, Michael E</creator><creatorcontrib>Amirian, E. Susan ; Marquez-Do, Deborah ; Bondy, Melissa L ; Scheurer, Michael E</creatorcontrib><description>Abstract Objective: An inverse association between personal history of allergies/asthma and glioma risk has been fairly consistently reported in the epidemiologic literature. However, the role of regular antihistamine use remains controversial due to a small number of studies reporting contradictory findings. We evaluated the association between regular use of oral antihistamines and glioma risk, adjusting for a number of relevant factors (e.g., immunoglobulin E levels and history of chickenpox). Methods : We used a subset of the Harris County Case-Control Study, which included 362 pathologically confirmed glioma cases and 462 cancer-free controls, to evaluate this association using unconditional multivariable logistic regression. These models were run among the overall study population and stratified by allergy status. Cox regression was utilized to examine whether antihistamine use was associated with mortality among all cases and separately among high-grade cases. Results : Antihistamine use was strongly associated with glioma risk among those with a positive allergy/asthma history (OR: 4.19, 95% CI: 2.06–8.51), but not among those with a negative history (OR: 1.59, 95% CI: 0.95–2.67). There were no significant associations between antihistamine use and survival among cases. Conclusion : The current study implies that regular antihistamine use may increase glioma risk. However, several larger studies are necessary before definitive conclusions can be drawn.</description><identifier>ISSN: 1877-7821</identifier><identifier>EISSN: 1877-783X</identifier><identifier>DOI: 10.1016/j.canep.2013.08.004</identifier><identifier>PMID: 23994286</identifier><language>eng</language><publisher>Amsterdam: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Age ; Allergies ; Analysis. Health state ; Asthma ; Biological and medical sciences ; Brain neoplasms ; Brain Neoplasms - blood ; Brain Neoplasms - epidemiology ; Brain Neoplasms - pathology ; Cancer ; Cancer therapies ; Case-Control Studies ; Chemotherapy ; Confidence intervals ; Enzyme-Linked Immunosorbent Assay ; Epidemiology ; Female ; Follow-Up Studies ; General aspects ; Glioma - blood ; Glioma - epidemiology ; Glioma - pathology ; Hematology, Oncology and Palliative Medicine ; Histamine Antagonists - therapeutic use ; Humans ; Hypersensitivity ; Immunoglobulin E ; Immunoglobulin E - blood ; Internal Medicine ; Logistics ; Male ; Medical sciences ; Middle Aged ; Neoplasm Grading ; Population ; Prognosis ; Public health. Hygiene ; Public health. 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Susan</creatorcontrib><creatorcontrib>Marquez-Do, Deborah</creatorcontrib><creatorcontrib>Bondy, Melissa L</creatorcontrib><creatorcontrib>Scheurer, Michael E</creatorcontrib><title>Antihistamine use and immunoglobulin E levels in glioma risk and prognosis</title><title>Cancer epidemiology</title><addtitle>Cancer Epidemiol</addtitle><description>Abstract Objective: An inverse association between personal history of allergies/asthma and glioma risk has been fairly consistently reported in the epidemiologic literature. However, the role of regular antihistamine use remains controversial due to a small number of studies reporting contradictory findings. We evaluated the association between regular use of oral antihistamines and glioma risk, adjusting for a number of relevant factors (e.g., immunoglobulin E levels and history of chickenpox). Methods : We used a subset of the Harris County Case-Control Study, which included 362 pathologically confirmed glioma cases and 462 cancer-free controls, to evaluate this association using unconditional multivariable logistic regression. These models were run among the overall study population and stratified by allergy status. Cox regression was utilized to examine whether antihistamine use was associated with mortality among all cases and separately among high-grade cases. Results : Antihistamine use was strongly associated with glioma risk among those with a positive allergy/asthma history (OR: 4.19, 95% CI: 2.06–8.51), but not among those with a negative history (OR: 1.59, 95% CI: 0.95–2.67). There were no significant associations between antihistamine use and survival among cases. Conclusion : The current study implies that regular antihistamine use may increase glioma risk. However, several larger studies are necessary before definitive conclusions can be drawn.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Allergies</subject><subject>Analysis. Health state</subject><subject>Asthma</subject><subject>Biological and medical sciences</subject><subject>Brain neoplasms</subject><subject>Brain Neoplasms - blood</subject><subject>Brain Neoplasms - epidemiology</subject><subject>Brain Neoplasms - pathology</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Case-Control Studies</subject><subject>Chemotherapy</subject><subject>Confidence intervals</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Glioma - blood</subject><subject>Glioma - epidemiology</subject><subject>Glioma - pathology</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Histamine Antagonists - therapeutic use</subject><subject>Humans</subject><subject>Hypersensitivity</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin E - blood</subject><subject>Internal Medicine</subject><subject>Logistics</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Population</subject><subject>Prognosis</subject><subject>Public health. 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Susan</au><au>Marquez-Do, Deborah</au><au>Bondy, Melissa L</au><au>Scheurer, Michael E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antihistamine use and immunoglobulin E levels in glioma risk and prognosis</atitle><jtitle>Cancer epidemiology</jtitle><addtitle>Cancer Epidemiol</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>37</volume><issue>6</issue><spage>908</spage><epage>912</epage><pages>908-912</pages><issn>1877-7821</issn><eissn>1877-783X</eissn><abstract>Abstract Objective: An inverse association between personal history of allergies/asthma and glioma risk has been fairly consistently reported in the epidemiologic literature. However, the role of regular antihistamine use remains controversial due to a small number of studies reporting contradictory findings. We evaluated the association between regular use of oral antihistamines and glioma risk, adjusting for a number of relevant factors (e.g., immunoglobulin E levels and history of chickenpox). Methods : We used a subset of the Harris County Case-Control Study, which included 362 pathologically confirmed glioma cases and 462 cancer-free controls, to evaluate this association using unconditional multivariable logistic regression. These models were run among the overall study population and stratified by allergy status. Cox regression was utilized to examine whether antihistamine use was associated with mortality among all cases and separately among high-grade cases. Results : Antihistamine use was strongly associated with glioma risk among those with a positive allergy/asthma history (OR: 4.19, 95% CI: 2.06–8.51), but not among those with a negative history (OR: 1.59, 95% CI: 0.95–2.67). There were no significant associations between antihistamine use and survival among cases. Conclusion : The current study implies that regular antihistamine use may increase glioma risk. However, several larger studies are necessary before definitive conclusions can be drawn.</abstract><cop>Amsterdam</cop><pub>Elsevier Ltd</pub><pmid>23994286</pmid><doi>10.1016/j.canep.2013.08.004</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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subjects Adolescent
Adult
Age
Allergies
Analysis. Health state
Asthma
Biological and medical sciences
Brain neoplasms
Brain Neoplasms - blood
Brain Neoplasms - epidemiology
Brain Neoplasms - pathology
Cancer
Cancer therapies
Case-Control Studies
Chemotherapy
Confidence intervals
Enzyme-Linked Immunosorbent Assay
Epidemiology
Female
Follow-Up Studies
General aspects
Glioma - blood
Glioma - epidemiology
Glioma - pathology
Hematology, Oncology and Palliative Medicine
Histamine Antagonists - therapeutic use
Humans
Hypersensitivity
Immunoglobulin E
Immunoglobulin E - blood
Internal Medicine
Logistics
Male
Medical sciences
Middle Aged
Neoplasm Grading
Population
Prognosis
Public health. Hygiene
Public health. Hygiene-occupational medicine
Risk Factors
Studies
Survival
Survival Rate
Tumors
Young Adult
title Antihistamine use and immunoglobulin E levels in glioma risk and prognosis
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