A birth cohort study of viral infections in Vietnamese infants and children: study design, methods and characteristics of the cohort
In Ho Chi Minh City, Vietnam, more than one-third of admissions to the two paediatric hospitals are attributable to four infectious syndromes: dengue, diarrhoeal disease, acute respiratory infection, and hand, foot and mouth disease. We have established a large prospective birth cohort study to inve...
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| Veröffentlicht in: | BMC public health 2013-10, Vol.13 (1), p.937-937, Article 937 |
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| creator | Anders, Katherine L Nguyen, Nguyet Minh Van Thuy, Nguyen Thi Hieu, Nguyen Trong Nguyen, Hoa L Hong Tham, Nguyen Thi Thanh Ha, Phan Thi Lien, Le Bich Vinh Chau, Nguyen Van Simmons, Cameron P |
| description | In Ho Chi Minh City, Vietnam, more than one-third of admissions to the two paediatric hospitals are attributable to four infectious syndromes: dengue, diarrhoeal disease, acute respiratory infection, and hand, foot and mouth disease. We have established a large prospective birth cohort study to investigate individual, environmental, virological, and immunological determinants of infection and disease in infants. Specific research questions are focused on the role of maternal antibody in protection against infection in infancy, and the adaptive immune response to vaccination and natural infection. This paper presents the cohort design, methods, and baseline characteristics of the participants enrolled in the first two years.
Women are enrolled prior to delivery at one hospital in each of two catchment areas: an urban district in central HCMC, and a mixed urban/rural district in the Mekong Delta 150 km southwest of HCMC. Infants are enrolled within 3 days of birth, and maternal and cord blood samples are collected. Routine blood samples and data on growth, health status and vaccinations are collected from infants at scheduled visits at 4, 9 and 12 months. Clinical data and specimens are collected from infants presenting at a study clinic, or admitted to hospital, with any of the the four infectious syndromes of interest.
In four years since since the study began in July 2009, >6400 infants have been enrolled, and enrolment is ongoing. Attrition is low: 84% of participants have completed the full 12-month follow-up period. Baseline characteristics of the first 4300 enrollees are presented here. We have demonstrated the feasibility of establishing a large prospective study of infectious diseases in infancy in a resource-limited setting, with minimal loss to follow-up. Our linked socio-demographic, clinical and laboratory data will help elucidate the viral aetiology and epidemiology of common infectious diseases of infancy, and can inform the implemention of existing and future vaccines. This study furthermore provides a platform to which additional endpoints could be added in the future. |
| doi_str_mv | 10.1186/1471-2458-13-937 |
| format | Article |
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Women are enrolled prior to delivery at one hospital in each of two catchment areas: an urban district in central HCMC, and a mixed urban/rural district in the Mekong Delta 150 km southwest of HCMC. Infants are enrolled within 3 days of birth, and maternal and cord blood samples are collected. Routine blood samples and data on growth, health status and vaccinations are collected from infants at scheduled visits at 4, 9 and 12 months. Clinical data and specimens are collected from infants presenting at a study clinic, or admitted to hospital, with any of the the four infectious syndromes of interest.
In four years since since the study began in July 2009, >6400 infants have been enrolled, and enrolment is ongoing. Attrition is low: 84% of participants have completed the full 12-month follow-up period. Baseline characteristics of the first 4300 enrollees are presented here. We have demonstrated the feasibility of establishing a large prospective study of infectious diseases in infancy in a resource-limited setting, with minimal loss to follow-up. Our linked socio-demographic, clinical and laboratory data will help elucidate the viral aetiology and epidemiology of common infectious diseases of infancy, and can inform the implemention of existing and future vaccines. This study furthermore provides a platform to which additional endpoints could be added in the future.</description><identifier>ISSN: 1471-2458</identifier><identifier>EISSN: 1471-2458</identifier><identifier>DOI: 10.1186/1471-2458-13-937</identifier><identifier>PMID: 24103423</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Age ; Antibodies ; Asthma ; Child Health Services ; Children ; Children & youth ; Cohort Studies ; Dengue - epidemiology ; Dengue - immunology ; Dengue - prevention & control ; Diseases ; Epidemiology ; Female ; Hand, Foot and Mouth Disease - epidemiology ; Hand, Foot and Mouth Disease - immunology ; Hand, Foot and Mouth Disease - prevention & control ; Health aspects ; Hospitals ; Host-parasite relationships ; Humans ; Illnesses ; Immune response ; Infant ; Infant, Newborn ; Influenza, Human - epidemiology ; Influenza, Human - immunology ; Influenza, Human - prevention & control ; Lung diseases ; Male ; Methods ; Mortality ; Pathogenesis ; Population density ; Preventive medicine ; Prospective Studies ; Research Design ; Risk factors ; Rural areas ; Rural Population ; Study Protocol ; Tropical diseases ; Urban Population ; Vietnam ; Vietnam - epidemiology ; Viral antibodies ; Viral infections ; Virus Diseases - epidemiology ; Virus Diseases - immunology ; Virus Diseases - prevention & control</subject><ispartof>BMC public health, 2013-10, Vol.13 (1), p.937-937, Article 937</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Anders et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Copyright © 2013 Anders et al.; licensee BioMed Central Ltd. 2013 Anders et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b551t-6cb9cdcee26542f43fdca82682e006d2c6beef6f7ba8cee12d802baefaa072a33</citedby><cites>FETCH-LOGICAL-b551t-6cb9cdcee26542f43fdca82682e006d2c6beef6f7ba8cee12d802baefaa072a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851864/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851864/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24103423$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anders, Katherine L</creatorcontrib><creatorcontrib>Nguyen, Nguyet Minh</creatorcontrib><creatorcontrib>Van Thuy, Nguyen Thi</creatorcontrib><creatorcontrib>Hieu, Nguyen Trong</creatorcontrib><creatorcontrib>Nguyen, Hoa L</creatorcontrib><creatorcontrib>Hong Tham, Nguyen Thi</creatorcontrib><creatorcontrib>Thanh Ha, Phan Thi</creatorcontrib><creatorcontrib>Lien, Le Bich</creatorcontrib><creatorcontrib>Vinh Chau, Nguyen Van</creatorcontrib><creatorcontrib>Simmons, Cameron P</creatorcontrib><title>A birth cohort study of viral infections in Vietnamese infants and children: study design, methods and characteristics of the cohort</title><title>BMC public health</title><addtitle>BMC Public Health</addtitle><description>In Ho Chi Minh City, Vietnam, more than one-third of admissions to the two paediatric hospitals are attributable to four infectious syndromes: dengue, diarrhoeal disease, acute respiratory infection, and hand, foot and mouth disease. We have established a large prospective birth cohort study to investigate individual, environmental, virological, and immunological determinants of infection and disease in infants. Specific research questions are focused on the role of maternal antibody in protection against infection in infancy, and the adaptive immune response to vaccination and natural infection. This paper presents the cohort design, methods, and baseline characteristics of the participants enrolled in the first two years.
Women are enrolled prior to delivery at one hospital in each of two catchment areas: an urban district in central HCMC, and a mixed urban/rural district in the Mekong Delta 150 km southwest of HCMC. Infants are enrolled within 3 days of birth, and maternal and cord blood samples are collected. Routine blood samples and data on growth, health status and vaccinations are collected from infants at scheduled visits at 4, 9 and 12 months. Clinical data and specimens are collected from infants presenting at a study clinic, or admitted to hospital, with any of the the four infectious syndromes of interest.
In four years since since the study began in July 2009, >6400 infants have been enrolled, and enrolment is ongoing. Attrition is low: 84% of participants have completed the full 12-month follow-up period. Baseline characteristics of the first 4300 enrollees are presented here. We have demonstrated the feasibility of establishing a large prospective study of infectious diseases in infancy in a resource-limited setting, with minimal loss to follow-up. Our linked socio-demographic, clinical and laboratory data will help elucidate the viral aetiology and epidemiology of common infectious diseases of infancy, and can inform the implemention of existing and future vaccines. This study furthermore provides a platform to which additional endpoints could be added in the future.</description><subject>Adult</subject><subject>Age</subject><subject>Antibodies</subject><subject>Asthma</subject><subject>Child Health Services</subject><subject>Children</subject><subject>Children & youth</subject><subject>Cohort Studies</subject><subject>Dengue - epidemiology</subject><subject>Dengue - immunology</subject><subject>Dengue - prevention & control</subject><subject>Diseases</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Hand, Foot and Mouth Disease - epidemiology</subject><subject>Hand, Foot and Mouth Disease - immunology</subject><subject>Hand, Foot and Mouth Disease - prevention & control</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Host-parasite relationships</subject><subject>Humans</subject><subject>Illnesses</subject><subject>Immune response</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Influenza, Human - epidemiology</subject><subject>Influenza, Human - immunology</subject><subject>Influenza, Human - prevention & control</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Methods</subject><subject>Mortality</subject><subject>Pathogenesis</subject><subject>Population density</subject><subject>Preventive medicine</subject><subject>Prospective Studies</subject><subject>Research Design</subject><subject>Risk factors</subject><subject>Rural areas</subject><subject>Rural Population</subject><subject>Study Protocol</subject><subject>Tropical diseases</subject><subject>Urban Population</subject><subject>Vietnam</subject><subject>Vietnam - epidemiology</subject><subject>Viral antibodies</subject><subject>Viral infections</subject><subject>Virus Diseases - epidemiology</subject><subject>Virus Diseases - immunology</subject><subject>Virus Diseases - prevention & control</subject><issn>1471-2458</issn><issn>1471-2458</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1Us1rFDEUD2KxH3r3JAGvTpuvyUw9CMtiVSj0ol5DJnnZSdlJapIt9O4fbobdrl1oySGP936_3_tE6D0l55T28oKKjjZMtH1DeXPJu1foZO96_cQ-Rqc53xJCu75lb9AxE5RwwfgJ-rvAg09lxCaOMRWcy8Y-4OjwvU96jX1wYIqPIVcT__ZQgp4gwxzQoWSsg8Vm9GubIHzesS1kvwqf8ARljPYRo5M2BZLPxZs8Zygj7LK-RUdOrzO82_1n6NfV15_L7831zbcfy8V1M7QtLY00w6WxBoDJVjAnuLNG90z2DAiRlhk5ADjpukH3FUWZ7QkbNDitScc052foy1b3bjNMUJVCqU2qu-QnnR5U1F4dRoIf1SreK963ddyiCiy3AoOPLwgcRkyc1LwFNW9BUa7qkqrKx10ZKf7ZQC7qNm5SqJ1XrKCilUTQ_6iVXoOq845V0Uw-G7VouZB1h2xGnT-Dqs_C5E0M4Hz1HxDIlmBSzDmB21dPiZqP6rl6Pzwd257weEX8HyB4ypQ</recordid><startdate>20131008</startdate><enddate>20131008</enddate><creator>Anders, Katherine L</creator><creator>Nguyen, Nguyet Minh</creator><creator>Van Thuy, Nguyen Thi</creator><creator>Hieu, Nguyen Trong</creator><creator>Nguyen, Hoa L</creator><creator>Hong Tham, Nguyen Thi</creator><creator>Thanh Ha, Phan Thi</creator><creator>Lien, Le Bich</creator><creator>Vinh Chau, Nguyen Van</creator><creator>Simmons, Cameron P</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L6V</scope><scope>M0S</scope><scope>M1P</scope><scope>M7S</scope><scope>PATMY</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>5PM</scope></search><sort><creationdate>20131008</creationdate><title>A birth cohort study of viral infections in Vietnamese infants and children: study design, methods and characteristics of the cohort</title><author>Anders, Katherine L ; Nguyen, Nguyet Minh ; Van Thuy, Nguyen Thi ; Hieu, Nguyen Trong ; Nguyen, Hoa L ; Hong Tham, Nguyen Thi ; Thanh Ha, Phan Thi ; Lien, Le Bich ; Vinh Chau, Nguyen Van ; Simmons, Cameron P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b551t-6cb9cdcee26542f43fdca82682e006d2c6beef6f7ba8cee12d802baefaa072a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Age</topic><topic>Antibodies</topic><topic>Asthma</topic><topic>Child Health Services</topic><topic>Children</topic><topic>Children & youth</topic><topic>Cohort Studies</topic><topic>Dengue - epidemiology</topic><topic>Dengue - immunology</topic><topic>Dengue - prevention & control</topic><topic>Diseases</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Hand, Foot and Mouth Disease - epidemiology</topic><topic>Hand, Foot and Mouth Disease - immunology</topic><topic>Hand, Foot and Mouth Disease - prevention & control</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>Host-parasite relationships</topic><topic>Humans</topic><topic>Illnesses</topic><topic>Immune response</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Influenza, Human - epidemiology</topic><topic>Influenza, Human - immunology</topic><topic>Influenza, Human - prevention & control</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Methods</topic><topic>Mortality</topic><topic>Pathogenesis</topic><topic>Population density</topic><topic>Preventive medicine</topic><topic>Prospective Studies</topic><topic>Research Design</topic><topic>Risk factors</topic><topic>Rural areas</topic><topic>Rural Population</topic><topic>Study Protocol</topic><topic>Tropical diseases</topic><topic>Urban Population</topic><topic>Vietnam</topic><topic>Vietnam - epidemiology</topic><topic>Viral antibodies</topic><topic>Viral infections</topic><topic>Virus Diseases - epidemiology</topic><topic>Virus Diseases - immunology</topic><topic>Virus Diseases - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anders, Katherine L</creatorcontrib><creatorcontrib>Nguyen, Nguyet Minh</creatorcontrib><creatorcontrib>Van Thuy, Nguyen Thi</creatorcontrib><creatorcontrib>Hieu, Nguyen Trong</creatorcontrib><creatorcontrib>Nguyen, Hoa L</creatorcontrib><creatorcontrib>Hong Tham, Nguyen Thi</creatorcontrib><creatorcontrib>Thanh Ha, Phan Thi</creatorcontrib><creatorcontrib>Lien, Le Bich</creatorcontrib><creatorcontrib>Vinh Chau, Nguyen Van</creatorcontrib><creatorcontrib>Simmons, Cameron P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Engineering Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Engineering Database</collection><collection>Environmental Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anders, Katherine L</au><au>Nguyen, Nguyet Minh</au><au>Van Thuy, Nguyen Thi</au><au>Hieu, Nguyen Trong</au><au>Nguyen, Hoa L</au><au>Hong Tham, Nguyen Thi</au><au>Thanh Ha, Phan Thi</au><au>Lien, Le Bich</au><au>Vinh Chau, Nguyen Van</au><au>Simmons, Cameron P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A birth cohort study of viral infections in Vietnamese infants and children: study design, methods and characteristics of the cohort</atitle><jtitle>BMC public health</jtitle><addtitle>BMC Public Health</addtitle><date>2013-10-08</date><risdate>2013</risdate><volume>13</volume><issue>1</issue><spage>937</spage><epage>937</epage><pages>937-937</pages><artnum>937</artnum><issn>1471-2458</issn><eissn>1471-2458</eissn><abstract>In Ho Chi Minh City, Vietnam, more than one-third of admissions to the two paediatric hospitals are attributable to four infectious syndromes: dengue, diarrhoeal disease, acute respiratory infection, and hand, foot and mouth disease. We have established a large prospective birth cohort study to investigate individual, environmental, virological, and immunological determinants of infection and disease in infants. Specific research questions are focused on the role of maternal antibody in protection against infection in infancy, and the adaptive immune response to vaccination and natural infection. This paper presents the cohort design, methods, and baseline characteristics of the participants enrolled in the first two years.
Women are enrolled prior to delivery at one hospital in each of two catchment areas: an urban district in central HCMC, and a mixed urban/rural district in the Mekong Delta 150 km southwest of HCMC. Infants are enrolled within 3 days of birth, and maternal and cord blood samples are collected. Routine blood samples and data on growth, health status and vaccinations are collected from infants at scheduled visits at 4, 9 and 12 months. Clinical data and specimens are collected from infants presenting at a study clinic, or admitted to hospital, with any of the the four infectious syndromes of interest.
In four years since since the study began in July 2009, >6400 infants have been enrolled, and enrolment is ongoing. Attrition is low: 84% of participants have completed the full 12-month follow-up period. Baseline characteristics of the first 4300 enrollees are presented here. We have demonstrated the feasibility of establishing a large prospective study of infectious diseases in infancy in a resource-limited setting, with minimal loss to follow-up. Our linked socio-demographic, clinical and laboratory data will help elucidate the viral aetiology and epidemiology of common infectious diseases of infancy, and can inform the implemention of existing and future vaccines. This study furthermore provides a platform to which additional endpoints could be added in the future.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>24103423</pmid><doi>10.1186/1471-2458-13-937</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | BMC public health, 2013-10, Vol.13 (1), p.937-937, Article 937 |
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| subjects | Adult Age Antibodies Asthma Child Health Services Children Children & youth Cohort Studies Dengue - epidemiology Dengue - immunology Dengue - prevention & control Diseases Epidemiology Female Hand, Foot and Mouth Disease - epidemiology Hand, Foot and Mouth Disease - immunology Hand, Foot and Mouth Disease - prevention & control Health aspects Hospitals Host-parasite relationships Humans Illnesses Immune response Infant Infant, Newborn Influenza, Human - epidemiology Influenza, Human - immunology Influenza, Human - prevention & control Lung diseases Male Methods Mortality Pathogenesis Population density Preventive medicine Prospective Studies Research Design Risk factors Rural areas Rural Population Study Protocol Tropical diseases Urban Population Vietnam Vietnam - epidemiology Viral antibodies Viral infections Virus Diseases - epidemiology Virus Diseases - immunology Virus Diseases - prevention & control |
| title | A birth cohort study of viral infections in Vietnamese infants and children: study design, methods and characteristics of the cohort |
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