GDSL LIPASE1 Modulates Plant Immunity through Feedback Regulation of Ethylene Signaling
Ethylene is a key signal in the regulation of plant defense responses. It is required for the expression and function of GDSL LIPASE1 (GLIP1) in Arabidopsis (Arabidopsis thaliana), which plays an important role in plant immunity. Here, we explore molecular mechanisms underlying the relationship betw...
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| Veröffentlicht in: | Plant physiology (Bethesda) 2013-12, Vol.163 (4), p.1776-1791 |
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| creator | Kim, Hye Gi Kwon, Sun Jae Jang, Young Jin Nam, Myung Hee Chung, Joo Hee Na, Yun-Cheol Guo, Hongwei Park, Ohkmae K. |
| description | Ethylene is a key signal in the regulation of plant defense responses. It is required for the expression and function of GDSL LIPASE1 (GLIP1) in Arabidopsis (Arabidopsis thaliana), which plays an important role in plant immunity. Here, we explore molecular mechanisms underlying the relationship between GLIP1 and ethylene signaling by an epistatic analysis of ethylene response mutants and GLIP1-overexpressing (35S:GLIP1) plants. We show that GLIP1 expression is regulated by ethylene signaling components and, further, that GLIP1 expression or application of petiole exudates from 35S:GLIP1 plants affects ethylene signaling both positively and negatively, leading to ETHYLENE RESPONSE FACTOR1 activation and ETHYLENE INSENSITIVE3 (EIN3) down-regulation, respectively. Additionally, 35S:GLIP1 plants or their exudates increase the expression of the salicylic acid biosynthesis gene SALICYLIC ACID INDUCTION-DEFICIENT2, known to be inhibited by EIN3 and EIN3-LIKE1. These results suggest that GLIP1 regulates plant immunity through positive and negative feedback regulation of ethylene signaling, and this is mediated by its activity to accumulate a systemic signal(s) in the phloem. We propose a model explaining how GLIP1 regulates the fine-tuning of ethylene signaling and ethylene-salicylic acid cross talk. |
| doi_str_mv | 10.1104/pp.113.225649 |
| format | Article |
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It is required for the expression and function of GDSL LIPASE1 (GLIP1) in Arabidopsis (Arabidopsis thaliana), which plays an important role in plant immunity. Here, we explore molecular mechanisms underlying the relationship between GLIP1 and ethylene signaling by an epistatic analysis of ethylene response mutants and GLIP1-overexpressing (35S:GLIP1) plants. We show that GLIP1 expression is regulated by ethylene signaling components and, further, that GLIP1 expression or application of petiole exudates from 35S:GLIP1 plants affects ethylene signaling both positively and negatively, leading to ETHYLENE RESPONSE FACTOR1 activation and ETHYLENE INSENSITIVE3 (EIN3) down-regulation, respectively. Additionally, 35S:GLIP1 plants or their exudates increase the expression of the salicylic acid biosynthesis gene SALICYLIC ACID INDUCTION-DEFICIENT2, known to be inhibited by EIN3 and EIN3-LIKE1. These results suggest that GLIP1 regulates plant immunity through positive and negative feedback regulation of ethylene signaling, and this is mediated by its activity to accumulate a systemic signal(s) in the phloem. We propose a model explaining how GLIP1 regulates the fine-tuning of ethylene signaling and ethylene-salicylic acid cross talk.</description><identifier>ISSN: 0032-0889</identifier><identifier>ISSN: 1532-2548</identifier><identifier>EISSN: 1532-2548</identifier><identifier>DOI: 10.1104/pp.113.225649</identifier><identifier>PMID: 24170202</identifier><identifier>CODEN: PPHYA5</identifier><language>eng</language><publisher>Rockville, MD: American Society of Plant Biologists</publisher><subject>Alternaria - physiology ; Arabidopsis - enzymology ; Arabidopsis - genetics ; Arabidopsis - immunology ; Arabidopsis - microbiology ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Biological and medical sciences ; carboxylic ester hydrolases ; Carboxylic Ester Hydrolases - metabolism ; Disease Resistance - genetics ; Disease Resistance - immunology ; Down regulation ; Down-Regulation - genetics ; Epistasis, Genetic ; ethylene ; Ethylenes - metabolism ; Feedback, Physiological ; Fundamental and applied biological sciences. Psychology ; Gene expression regulation ; Gene Expression Regulation, Plant ; Genes, Plant - genetics ; immunity ; Leaves ; Models, Biological ; Mutation - genetics ; Pathogens ; Petioles ; Phenotype ; Phenotypes ; Plant cells ; Plant Diseases - genetics ; Plant Diseases - immunology ; Plant Diseases - microbiology ; Plant Exudates - metabolism ; Plant immunity ; Plant Immunity - genetics ; Plant physiology and development ; Plants ; Protein Binding ; Salicylic Acid - metabolism ; Seedlings ; Signal Transduction - genetics ; Signal Transduction - immunology ; SIGNALING AND RESPONSE ; Up-Regulation - genetics</subject><ispartof>Plant physiology (Bethesda), 2013-12, Vol.163 (4), p.1776-1791</ispartof><rights>2013 American Society of Plant Biologists</rights><rights>2015 INIST-CNRS</rights><rights>2013 American Society of Plant Biologists. All Rights Reserved. 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c538t-bbe2a9afdc277fed873abaed2d187302379c6c237ecb89221205224a528531183</citedby><cites>FETCH-LOGICAL-c538t-bbe2a9afdc277fed873abaed2d187302379c6c237ecb89221205224a528531183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/23598895$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/23598895$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,777,781,800,882,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28001705$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24170202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hye Gi</creatorcontrib><creatorcontrib>Kwon, Sun Jae</creatorcontrib><creatorcontrib>Jang, Young Jin</creatorcontrib><creatorcontrib>Nam, Myung Hee</creatorcontrib><creatorcontrib>Chung, Joo Hee</creatorcontrib><creatorcontrib>Na, Yun-Cheol</creatorcontrib><creatorcontrib>Guo, Hongwei</creatorcontrib><creatorcontrib>Park, Ohkmae K.</creatorcontrib><title>GDSL LIPASE1 Modulates Plant Immunity through Feedback Regulation of Ethylene Signaling</title><title>Plant physiology (Bethesda)</title><addtitle>Plant Physiol</addtitle><description>Ethylene is a key signal in the regulation of plant defense responses. It is required for the expression and function of GDSL LIPASE1 (GLIP1) in Arabidopsis (Arabidopsis thaliana), which plays an important role in plant immunity. Here, we explore molecular mechanisms underlying the relationship between GLIP1 and ethylene signaling by an epistatic analysis of ethylene response mutants and GLIP1-overexpressing (35S:GLIP1) plants. We show that GLIP1 expression is regulated by ethylene signaling components and, further, that GLIP1 expression or application of petiole exudates from 35S:GLIP1 plants affects ethylene signaling both positively and negatively, leading to ETHYLENE RESPONSE FACTOR1 activation and ETHYLENE INSENSITIVE3 (EIN3) down-regulation, respectively. Additionally, 35S:GLIP1 plants or their exudates increase the expression of the salicylic acid biosynthesis gene SALICYLIC ACID INDUCTION-DEFICIENT2, known to be inhibited by EIN3 and EIN3-LIKE1. These results suggest that GLIP1 regulates plant immunity through positive and negative feedback regulation of ethylene signaling, and this is mediated by its activity to accumulate a systemic signal(s) in the phloem. We propose a model explaining how GLIP1 regulates the fine-tuning of ethylene signaling and ethylene-salicylic acid cross talk.</description><subject>Alternaria - physiology</subject><subject>Arabidopsis - enzymology</subject><subject>Arabidopsis - genetics</subject><subject>Arabidopsis - immunology</subject><subject>Arabidopsis - microbiology</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Biological and medical sciences</subject><subject>carboxylic ester hydrolases</subject><subject>Carboxylic Ester Hydrolases - metabolism</subject><subject>Disease Resistance - genetics</subject><subject>Disease Resistance - immunology</subject><subject>Down regulation</subject><subject>Down-Regulation - genetics</subject><subject>Epistasis, Genetic</subject><subject>ethylene</subject><subject>Ethylenes - metabolism</subject><subject>Feedback, Physiological</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene expression regulation</subject><subject>Gene Expression Regulation, Plant</subject><subject>Genes, Plant - genetics</subject><subject>immunity</subject><subject>Leaves</subject><subject>Models, Biological</subject><subject>Mutation - genetics</subject><subject>Pathogens</subject><subject>Petioles</subject><subject>Phenotype</subject><subject>Phenotypes</subject><subject>Plant cells</subject><subject>Plant Diseases - genetics</subject><subject>Plant Diseases - immunology</subject><subject>Plant Diseases - microbiology</subject><subject>Plant Exudates - metabolism</subject><subject>Plant immunity</subject><subject>Plant Immunity - genetics</subject><subject>Plant physiology and development</subject><subject>Plants</subject><subject>Protein Binding</subject><subject>Salicylic Acid - metabolism</subject><subject>Seedlings</subject><subject>Signal Transduction - genetics</subject><subject>Signal Transduction - immunology</subject><subject>SIGNALING AND RESPONSE</subject><subject>Up-Regulation - genetics</subject><issn>0032-0889</issn><issn>1532-2548</issn><issn>1532-2548</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EokvhyBHkCxKXFHtsb5wLUlW2ZaVFVCyIo-U4TjYlsYPtIO2_x6tdWjhxeiPNp6c38xB6SckFpYS_m6as7AJALHn1CC2oYFCA4PIxWhCSZyJldYaexXhHCKGM8qfoDDgtCRBYoO83H7YbvFnfXm5XFH_yzTzoZCO-HbRLeD2Os-vTHqdd8HO3w9fWNrU2P_AX2x3I3jvsW7xKu_1gncXbvnN66F33HD1p9RDti5Oeo2_Xq69XH4vN55v11eWmMILJVNS1BV3ptjFQlq1tZMl0rW0DDc0jAVZWZmmyWFPLCoACEQBcC5CCUSrZOXp_9J3merSNsS4FPagp9KMOe-V1r_7duH6nOv9LMSnyB3g2eHsyCP7nbGNSYx-NHfL91s9RweFrtCxp-V-U8iXPzyZwQIsjaoKPMdj2PhEl6tCbmqasTB17y_zrv8-4p_8UlYE3J0BHo4c2aGf6-MDJnLIkInOvjtxdTD487JmocjTBfgM6zqj2</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Kim, Hye Gi</creator><creator>Kwon, Sun Jae</creator><creator>Jang, Young Jin</creator><creator>Nam, Myung Hee</creator><creator>Chung, Joo Hee</creator><creator>Na, Yun-Cheol</creator><creator>Guo, Hongwei</creator><creator>Park, Ohkmae K.</creator><general>American Society of Plant Biologists</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20131201</creationdate><title>GDSL LIPASE1 Modulates Plant Immunity through Feedback Regulation of Ethylene Signaling</title><author>Kim, Hye Gi ; Kwon, Sun Jae ; Jang, Young Jin ; Nam, Myung Hee ; Chung, Joo Hee ; Na, Yun-Cheol ; Guo, Hongwei ; Park, Ohkmae K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c538t-bbe2a9afdc277fed873abaed2d187302379c6c237ecb89221205224a528531183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alternaria - physiology</topic><topic>Arabidopsis - enzymology</topic><topic>Arabidopsis - genetics</topic><topic>Arabidopsis - immunology</topic><topic>Arabidopsis - microbiology</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Biological and medical sciences</topic><topic>carboxylic ester hydrolases</topic><topic>Carboxylic Ester Hydrolases - metabolism</topic><topic>Disease Resistance - genetics</topic><topic>Disease Resistance - immunology</topic><topic>Down regulation</topic><topic>Down-Regulation - genetics</topic><topic>Epistasis, Genetic</topic><topic>ethylene</topic><topic>Ethylenes - metabolism</topic><topic>Feedback, Physiological</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene expression regulation</topic><topic>Gene Expression Regulation, Plant</topic><topic>Genes, Plant - genetics</topic><topic>immunity</topic><topic>Leaves</topic><topic>Models, Biological</topic><topic>Mutation - genetics</topic><topic>Pathogens</topic><topic>Petioles</topic><topic>Phenotype</topic><topic>Phenotypes</topic><topic>Plant cells</topic><topic>Plant Diseases - genetics</topic><topic>Plant Diseases - immunology</topic><topic>Plant Diseases - microbiology</topic><topic>Plant Exudates - metabolism</topic><topic>Plant immunity</topic><topic>Plant Immunity - genetics</topic><topic>Plant physiology and development</topic><topic>Plants</topic><topic>Protein Binding</topic><topic>Salicylic Acid - metabolism</topic><topic>Seedlings</topic><topic>Signal Transduction - genetics</topic><topic>Signal Transduction - immunology</topic><topic>SIGNALING AND RESPONSE</topic><topic>Up-Regulation - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hye Gi</creatorcontrib><creatorcontrib>Kwon, Sun Jae</creatorcontrib><creatorcontrib>Jang, Young Jin</creatorcontrib><creatorcontrib>Nam, Myung Hee</creatorcontrib><creatorcontrib>Chung, Joo Hee</creatorcontrib><creatorcontrib>Na, Yun-Cheol</creatorcontrib><creatorcontrib>Guo, Hongwei</creatorcontrib><creatorcontrib>Park, Ohkmae K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Plant physiology (Bethesda)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hye Gi</au><au>Kwon, Sun Jae</au><au>Jang, Young Jin</au><au>Nam, Myung Hee</au><au>Chung, Joo Hee</au><au>Na, Yun-Cheol</au><au>Guo, Hongwei</au><au>Park, Ohkmae K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GDSL LIPASE1 Modulates Plant Immunity through Feedback Regulation of Ethylene Signaling</atitle><jtitle>Plant physiology (Bethesda)</jtitle><addtitle>Plant Physiol</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>163</volume><issue>4</issue><spage>1776</spage><epage>1791</epage><pages>1776-1791</pages><issn>0032-0889</issn><issn>1532-2548</issn><eissn>1532-2548</eissn><coden>PPHYA5</coden><abstract>Ethylene is a key signal in the regulation of plant defense responses. It is required for the expression and function of GDSL LIPASE1 (GLIP1) in Arabidopsis (Arabidopsis thaliana), which plays an important role in plant immunity. Here, we explore molecular mechanisms underlying the relationship between GLIP1 and ethylene signaling by an epistatic analysis of ethylene response mutants and GLIP1-overexpressing (35S:GLIP1) plants. We show that GLIP1 expression is regulated by ethylene signaling components and, further, that GLIP1 expression or application of petiole exudates from 35S:GLIP1 plants affects ethylene signaling both positively and negatively, leading to ETHYLENE RESPONSE FACTOR1 activation and ETHYLENE INSENSITIVE3 (EIN3) down-regulation, respectively. Additionally, 35S:GLIP1 plants or their exudates increase the expression of the salicylic acid biosynthesis gene SALICYLIC ACID INDUCTION-DEFICIENT2, known to be inhibited by EIN3 and EIN3-LIKE1. These results suggest that GLIP1 regulates plant immunity through positive and negative feedback regulation of ethylene signaling, and this is mediated by its activity to accumulate a systemic signal(s) in the phloem. We propose a model explaining how GLIP1 regulates the fine-tuning of ethylene signaling and ethylene-salicylic acid cross talk.</abstract><cop>Rockville, MD</cop><pub>American Society of Plant Biologists</pub><pmid>24170202</pmid><doi>10.1104/pp.113.225649</doi><tpages>16</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Alternaria - physiology Arabidopsis - enzymology Arabidopsis - genetics Arabidopsis - immunology Arabidopsis - microbiology Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Biological and medical sciences carboxylic ester hydrolases Carboxylic Ester Hydrolases - metabolism Disease Resistance - genetics Disease Resistance - immunology Down regulation Down-Regulation - genetics Epistasis, Genetic ethylene Ethylenes - metabolism Feedback, Physiological Fundamental and applied biological sciences. Psychology Gene expression regulation Gene Expression Regulation, Plant Genes, Plant - genetics immunity Leaves Models, Biological Mutation - genetics Pathogens Petioles Phenotype Phenotypes Plant cells Plant Diseases - genetics Plant Diseases - immunology Plant Diseases - microbiology Plant Exudates - metabolism Plant immunity Plant Immunity - genetics Plant physiology and development Plants Protein Binding Salicylic Acid - metabolism Seedlings Signal Transduction - genetics Signal Transduction - immunology SIGNALING AND RESPONSE Up-Regulation - genetics |
| title | GDSL LIPASE1 Modulates Plant Immunity through Feedback Regulation of Ethylene Signaling |
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