Lipoprotein(a) is not related to markers of insulin resistance in pregnancy
Dyslipidemia, a major risk factor for cardiovascular disease is a common finding in patients with type 2 diabetes and among women with gestational diabetes. Elevated levels of lipoprotein(a) [Lp(a)] are linked to increased risk of cardiovascular disease. However, its relationship with insulin resist...
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| Veröffentlicht in: | Cardiovascular Diabetology 2013-10, Vol.12 (1), p.138-138, Article 138 |
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| creator | Todoric, Jelena Handisurya, Ammon Leitner, Karoline Harreiter, Juergen Hoermann, Gregor Kautzky-Willer, Alexandra |
| description | Dyslipidemia, a major risk factor for cardiovascular disease is a common finding in patients with type 2 diabetes and among women with gestational diabetes. Elevated levels of lipoprotein(a) [Lp(a)] are linked to increased risk of cardiovascular disease. However, its relationship with insulin resistance, type 2 diabetes and gestational diabetes is controversial and unproven. Here we aimed to clarify whether Lp(a) levels are associated with insulin sensitivity in pregnancy.
Sixty-four women with gestational diabetes and 165 with normal glucose tolerance were enrolled in the study. Fasting Lp(a) serum levels were measured in all women at 24-28 weeks of gestation.
In pregnancy, there was no significant difference in serum Lp(a) concentrations between the two groups. Its level did not correlate with markers of insulin resistance (HOMA-IR), insulin sensitivity (HOMA-S%), pancreatic beta-cell function (HOMA-B%) and insulin sensitivity in dynamic conditions (OGIS). In addition, fasting glucose and insulin levels and those throughout an oral glucose tolerance test were independent of Lp(a) concentrations in our study group.
Lp(a) levels in pregnant women do not differ with respect to the presence or absence of gestational diabetes. Although influenced by some components of the lipid profile, such as triglycerides and HDL-C, insulin resistance in pregnancy is not affected by Lp(a). |
| doi_str_mv | 10.1186/1475-2840-12-138 |
| format | Article |
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Sixty-four women with gestational diabetes and 165 with normal glucose tolerance were enrolled in the study. Fasting Lp(a) serum levels were measured in all women at 24-28 weeks of gestation.
In pregnancy, there was no significant difference in serum Lp(a) concentrations between the two groups. Its level did not correlate with markers of insulin resistance (HOMA-IR), insulin sensitivity (HOMA-S%), pancreatic beta-cell function (HOMA-B%) and insulin sensitivity in dynamic conditions (OGIS). In addition, fasting glucose and insulin levels and those throughout an oral glucose tolerance test were independent of Lp(a) concentrations in our study group.
Lp(a) levels in pregnant women do not differ with respect to the presence or absence of gestational diabetes. Although influenced by some components of the lipid profile, such as triglycerides and HDL-C, insulin resistance in pregnancy is not affected by Lp(a).</description><identifier>ISSN: 1475-2840</identifier><identifier>EISSN: 1475-2840</identifier><identifier>DOI: 10.1186/1475-2840-12-138</identifier><identifier>PMID: 24083682</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Adult ; Biological markers ; Biomarkers - blood ; Blood Glucose - metabolism ; Blood lipoproteins ; Case-Control Studies ; Cholesterol ; Diabetes ; Diabetes, Gestational - blood ; Diabetes, Gestational - diagnosis ; Diet ; Female ; Gestational Age ; Glucose ; Glucose Tolerance Test ; Glucose tolerance tests ; Health aspects ; Humans ; Insulin ; Insulin - blood ; Insulin Resistance ; Insulin-Secreting Cells - metabolism ; Lipids ; Lipoprotein(a) - blood ; Lipoproteins ; Original Investigation ; Physiological aspects ; Pregnancy ; Proteolipids ; Risk factors ; Womens health</subject><ispartof>Cardiovascular Diabetology, 2013-10, Vol.12 (1), p.138-138, Article 138</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Todoric et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Copyright © 2013 Todoric et al.; licensee BioMed Central Ltd. 2013 Todoric et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b551t-a8e8b499c2d5db034b55dad3457b16fb1d1cc3bbba2a56f7478c257e947a44993</citedby><cites>FETCH-LOGICAL-b551t-a8e8b499c2d5db034b55dad3457b16fb1d1cc3bbba2a56f7478c257e947a44993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849879/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3849879/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24083682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Todoric, Jelena</creatorcontrib><creatorcontrib>Handisurya, Ammon</creatorcontrib><creatorcontrib>Leitner, Karoline</creatorcontrib><creatorcontrib>Harreiter, Juergen</creatorcontrib><creatorcontrib>Hoermann, Gregor</creatorcontrib><creatorcontrib>Kautzky-Willer, Alexandra</creatorcontrib><title>Lipoprotein(a) is not related to markers of insulin resistance in pregnancy</title><title>Cardiovascular Diabetology</title><addtitle>Cardiovasc Diabetol</addtitle><description>Dyslipidemia, a major risk factor for cardiovascular disease is a common finding in patients with type 2 diabetes and among women with gestational diabetes. Elevated levels of lipoprotein(a) [Lp(a)] are linked to increased risk of cardiovascular disease. However, its relationship with insulin resistance, type 2 diabetes and gestational diabetes is controversial and unproven. Here we aimed to clarify whether Lp(a) levels are associated with insulin sensitivity in pregnancy.
Sixty-four women with gestational diabetes and 165 with normal glucose tolerance were enrolled in the study. Fasting Lp(a) serum levels were measured in all women at 24-28 weeks of gestation.
In pregnancy, there was no significant difference in serum Lp(a) concentrations between the two groups. Its level did not correlate with markers of insulin resistance (HOMA-IR), insulin sensitivity (HOMA-S%), pancreatic beta-cell function (HOMA-B%) and insulin sensitivity in dynamic conditions (OGIS). In addition, fasting glucose and insulin levels and those throughout an oral glucose tolerance test were independent of Lp(a) concentrations in our study group.
Lp(a) levels in pregnant women do not differ with respect to the presence or absence of gestational diabetes. Although influenced by some components of the lipid profile, such as triglycerides and HDL-C, insulin resistance in pregnancy is not affected by Lp(a).</description><subject>Adult</subject><subject>Biological markers</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Blood lipoproteins</subject><subject>Case-Control Studies</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Diabetes, Gestational - blood</subject><subject>Diabetes, Gestational - diagnosis</subject><subject>Diet</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Glucose</subject><subject>Glucose Tolerance Test</subject><subject>Glucose tolerance tests</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Insulin-Secreting Cells - metabolism</subject><subject>Lipids</subject><subject>Lipoprotein(a) - blood</subject><subject>Lipoproteins</subject><subject>Original Investigation</subject><subject>Physiological aspects</subject><subject>Pregnancy</subject><subject>Proteolipids</subject><subject>Risk factors</subject><subject>Womens health</subject><issn>1475-2840</issn><issn>1475-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1Uk1P3DAUtCqq8tHee0KRuMAhEMd24lwqoVX5ECtxac-W7bxsDYmd2kkl_j1vWVgBovLB9ryZec8jE_KdFqeUyuqM8lrkpeRFTsucMvmJ7G2hnVfnXbKf0l1R0FpW9AvZLXkhWSXLPXKzdGMYY5jA-WN9krmU-TBlEXo9QZtNIRt0vIeYstBlzqe5dx6ryaVJewsIZWOElcfLw1fyudN9gm_P-wH5ffHz1-IqX95eXi_Ol7kRgk65liANbxpbtqI1BeMIt7plXNSGVp2hLbWWGWN0qUXV1byWthQ1NLzWHHXsgPzY-I6zGaC14KeoezVGh7M-qKCdelvx7o9ahX-KSd7Iem2w2BgYF_5j8LZiw6DWYap1mIqWCrNGl-PnMWL4O0Oa1OCShb7XHsKcUCAaKmTx1PDoHfUuzNFjSMhiyGKcrg1PN6yV7kE53wVsbnG1MDgbPHQO8XMkVwKNGQqKjcDGkFKEbvsEilPiB_lo6MPX2W0FLz-CPQK8l7ab</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Todoric, Jelena</creator><creator>Handisurya, Ammon</creator><creator>Leitner, Karoline</creator><creator>Harreiter, Juergen</creator><creator>Hoermann, Gregor</creator><creator>Kautzky-Willer, Alexandra</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20131001</creationdate><title>Lipoprotein(a) is not related to markers of insulin resistance in pregnancy</title><author>Todoric, Jelena ; Handisurya, Ammon ; Leitner, Karoline ; Harreiter, Juergen ; Hoermann, Gregor ; Kautzky-Willer, Alexandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b551t-a8e8b499c2d5db034b55dad3457b16fb1d1cc3bbba2a56f7478c257e947a44993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Biological markers</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Blood lipoproteins</topic><topic>Case-Control Studies</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Diabetes, Gestational - blood</topic><topic>Diabetes, Gestational - diagnosis</topic><topic>Diet</topic><topic>Female</topic><topic>Gestational Age</topic><topic>Glucose</topic><topic>Glucose Tolerance Test</topic><topic>Glucose tolerance tests</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Insulin-Secreting Cells - metabolism</topic><topic>Lipids</topic><topic>Lipoprotein(a) - blood</topic><topic>Lipoproteins</topic><topic>Original Investigation</topic><topic>Physiological aspects</topic><topic>Pregnancy</topic><topic>Proteolipids</topic><topic>Risk factors</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Todoric, Jelena</creatorcontrib><creatorcontrib>Handisurya, Ammon</creatorcontrib><creatorcontrib>Leitner, Karoline</creatorcontrib><creatorcontrib>Harreiter, Juergen</creatorcontrib><creatorcontrib>Hoermann, Gregor</creatorcontrib><creatorcontrib>Kautzky-Willer, Alexandra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Academic</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cardiovascular Diabetology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Todoric, Jelena</au><au>Handisurya, Ammon</au><au>Leitner, Karoline</au><au>Harreiter, Juergen</au><au>Hoermann, Gregor</au><au>Kautzky-Willer, Alexandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipoprotein(a) is not related to markers of insulin resistance in pregnancy</atitle><jtitle>Cardiovascular Diabetology</jtitle><addtitle>Cardiovasc Diabetol</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>12</volume><issue>1</issue><spage>138</spage><epage>138</epage><pages>138-138</pages><artnum>138</artnum><issn>1475-2840</issn><eissn>1475-2840</eissn><abstract>Dyslipidemia, a major risk factor for cardiovascular disease is a common finding in patients with type 2 diabetes and among women with gestational diabetes. Elevated levels of lipoprotein(a) [Lp(a)] are linked to increased risk of cardiovascular disease. However, its relationship with insulin resistance, type 2 diabetes and gestational diabetes is controversial and unproven. Here we aimed to clarify whether Lp(a) levels are associated with insulin sensitivity in pregnancy.
Sixty-four women with gestational diabetes and 165 with normal glucose tolerance were enrolled in the study. Fasting Lp(a) serum levels were measured in all women at 24-28 weeks of gestation.
In pregnancy, there was no significant difference in serum Lp(a) concentrations between the two groups. Its level did not correlate with markers of insulin resistance (HOMA-IR), insulin sensitivity (HOMA-S%), pancreatic beta-cell function (HOMA-B%) and insulin sensitivity in dynamic conditions (OGIS). In addition, fasting glucose and insulin levels and those throughout an oral glucose tolerance test were independent of Lp(a) concentrations in our study group.
Lp(a) levels in pregnant women do not differ with respect to the presence or absence of gestational diabetes. Although influenced by some components of the lipid profile, such as triglycerides and HDL-C, insulin resistance in pregnancy is not affected by Lp(a).</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>24083682</pmid><doi>10.1186/1475-2840-12-138</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biological markers Biomarkers - blood Blood Glucose - metabolism Blood lipoproteins Case-Control Studies Cholesterol Diabetes Diabetes, Gestational - blood Diabetes, Gestational - diagnosis Diet Female Gestational Age Glucose Glucose Tolerance Test Glucose tolerance tests Health aspects Humans Insulin Insulin - blood Insulin Resistance Insulin-Secreting Cells - metabolism Lipids Lipoprotein(a) - blood Lipoproteins Original Investigation Physiological aspects Pregnancy Proteolipids Risk factors Womens health |
| title | Lipoprotein(a) is not related to markers of insulin resistance in pregnancy |
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