Mitochondrial iron accumulation with age and functional consequences

Summary During the aging process, an accumulation of non‐heme iron disrupts cellular homeostasis and contributes to the mitochondrial dysfunction typical of various neuromuscular degenerative diseases. Few studies have investigated the effects of iron accumulation on mitochondrial integrity and func...

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Veröffentlicht in:	Aging cell 2008-10, Vol.7 (5), p.706-716
Hauptverfasser:	Seo, Arnold Y. , Xu, Jinze , Servais, Stephane , Hofer, Tim , Marzetti, Emanuele , Wohlgemuth, Stephanie E. , Knutson, Mitchell D. , Chung, Hae Young , Leeuwenburgh, Christiaan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Aging - physiology Animals Apoptosis - physiology Body Weight - physiology Calcium - metabolism Electron Transport - physiology Iron - adverse effects Iron - metabolism Iron - physiology Male Mitochondria - metabolism Mitochondria - physiology Mitochondria, Liver - physiology Mitochondria, Muscle - physiology mitochondrial aging mitochondrial iron homeostasis mitochondrial permeability transition pore mitochondrial RNA Muscle, Skeletal - physiology Oxidation-Reduction oxidative stress Rats Rats, Inbred BN Rats, Inbred F344 skeletal muscle subsarcolemmal and interfibrillar mitochondria
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