Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state

Direct reprogramming of adult somatic cells into alternative cell types has been shown for several lineages. We previously showed that GATA4, MEF2C, and TBX5 (GMT) directly reprogrammed nonmyocyte mouse heart cells into induced cardiomyocyte-like cells (iCMs) in vitro and in vivo. However, GMT alone...

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Veröffentlicht in:	Stem cell reports 2013-09, Vol.1 (3), p.235-247
Hauptverfasser:	Fu, Ji-Dong, Stone, Nicole R, Liu, Lei, Spencer, C Ian, Qian, Li, Hayashi, Yohei, Delgado-Olguin, Paul, Ding, Sheng, Bruneau, Benoit G, Srivastava, Deepak
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics Cell Lineage Cellular Reprogramming - genetics DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - genetics Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Fibroblasts - metabolism GATA4 Transcription Factor - biosynthesis GATA4 Transcription Factor - genetics Gene Expression Regulation, Developmental - genetics Humans MEF2 Transcription Factors - biosynthesis MEF2 Transcription Factors - genetics Mice Myocytes, Cardiac - metabolism Nuclear Proteins - biosynthesis Nuclear Proteins - genetics Signal Transduction T-Box Domain Proteins - biosynthesis T-Box Domain Proteins - genetics Trans-Activators - biosynthesis Trans-Activators - genetics Transcription Factors - biosynthesis Transcription Factors - genetics Transforming Growth Factor beta - metabolism
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