Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

Background & Aims Activated hepatic stellate cells (HSCs), the main fibrogenic cell type in the liver, undergo apoptosis after cessation of liver injury, which contributes to resolution of fibrosis. In this study, we investigated whether HSC deactivation constitutes an additional mechanism of li...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2012-10, Vol.143 (4), p.1073-1083.e22
Hauptverfasser:	Troeger, Juliane S, Mederacke, Ingmar, Gwak, Geum–Youn, Dapito, Dianne H, Mu, Xueru, Hsu, Christine C, Pradere, Jean–Philippe, Friedman, Richard A, Schwabe, Robert F
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - drug effects Actins - genetics Actins - metabolism Animals Biomarkers - metabolism Carbon Tetrachloride Cells, Cultured Cirrhosis Collagen Type I - genetics Collagen Type I, alpha 1 Chain Gastroenterology and Hepatology Gene Expression Genetic Techniques Genotype Green Fluorescent Proteins - metabolism Hepatic Stellate Cells - metabolism Hepatic Stellate Cells - pathology Hepatitis Integrases - drug effects Integrases - genetics Integrases - metabolism Liver Cirrhosis - chemically induced Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Male Mice Mice, Transgenic Mouse Model Myofibroblast Myofibroblasts - metabolism Platelet-Derived Growth Factor - pharmacology Polymerase Chain Reaction RNA, Messenger - metabolism Tamoxifen - pharmacology Transforming Growth Factor beta - pharmacology Vimentin - drug effects Vimentin - genetics Vimentin - metabolism
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