An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry

A genome-wide RNA interference analysis identifies the septin family of cytoskeletal filaments as important regulators of store-operated Ca 2+ entry into the cell; septins are shown to organize plasma membrane microdomains important in STIM1 and ORAI1 signalling, and may also be relevant in membrane...

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Veröffentlicht in:	Nature (London) 2013-07, Vol.499 (7457), p.238-242
Hauptverfasser:	Sharma, Sonia, Quintana, Ariel, Findlay, Gregory M., Mettlen, Marcel, Baust, Beate, Jain, Mohit, Nilsson, Roland, Rao, Anjana, Hogan, Patrick G.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/516 Calcium - metabolism Calcium Channels - metabolism Calcium Signaling Cell Membrane - metabolism Endoplasmic Reticulum - metabolism Genome, Human HeLa Cells Humanities and Social Sciences Humans letter Membrane Proteins - metabolism multidisciplinary Neoplasm Proteins - metabolism NFATC Transcription Factors - metabolism ORAI1 Protein Protein Transport RNA Interference RNA, Small Interfering - genetics Science Septins - deficiency Septins - genetics Septins - metabolism Signal Transduction Stromal Interaction Molecule 1
Online-Zugang:	Volltext
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