Macrophage migratory inhibitory factor promotes bladder cancer progression via increasing proliferation and angiogenesis

Macrophage migratory inhibitory factor (MIF) is a proinflammatory cytokine shown to promote tumorigenesis. Using the N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) model of bladder cancer, we previously showed that MIF knockout mice display decreased angiogenesis and invasion compared with wild-type....

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Veröffentlicht in:	Carcinogenesis (New York) 2013-12, Vol.34 (12), p.2891-2899
Hauptverfasser:	Choudhary, Shilpa, Hegde, Poornima, Pruitt, James R, Sielecki, Thais M, Choudhary, Dharamainder, Scarpato, Kristen, Degraff, David J, Pilbeam, Carol C, Taylor, 3rd, John A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Proliferation Disease Progression Hep G2 Cells Humans Macrophage Migration-Inhibitory Factors - antagonists & inhibitors Macrophage Migration-Inhibitory Factors - genetics Macrophage Migration-Inhibitory Factors - metabolism Male MAP Kinase Signaling System - genetics Mice Mice, Inbred C57BL Neovascularization, Pathologic - genetics Neovascularization, Pathologic - pathology Original Manuscript Phosphorylation - genetics Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism RNA, Messenger Urinary Bladder - metabolism Urinary Bladder - pathology Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism
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