HIV Infection Is Associated With Reduced Pulmonary Diffusing Capacity
INTRODUCTION:Prior studies comparing abnormalities in pulmonary function between HIV-infected and HIV-uninfected persons in the current era are limited. OBJECTIVES:To determine the pattern and severity of impairment in pulmonary function in HIV-infected compared with HIV-uninfected individuals. METH...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2013-11, Vol.64 (3), p.271-278 |
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| creator | Crothers, Kristina McGinnis, Kathleen Kleerup, Eric Wongtrakool, Cherry Hoo, Guy S Kim, Joon Sharafkhaneh, Amir Huang, Laurence Luo, Zhaoyu Thompson, Bruce Diaz, Philip Kirk, Gregory D Rom, William Detels, Roger Kingsley, Lawrence Morris, Alison |
| description | INTRODUCTION:Prior studies comparing abnormalities in pulmonary function between HIV-infected and HIV-uninfected persons in the current era are limited.
OBJECTIVES:To determine the pattern and severity of impairment in pulmonary function in HIV-infected compared with HIV-uninfected individuals.
METHODS:Cross-sectional analysis of 300 HIV-infected men and 289 HIV-uninfected men enrolled from 2009 to 2011 in 2 clinical centers of the Lung HIV Study. Participants completed pre- and postbronchodilator spirometry, diffusing capacity of the lung for carbon monoxide (DLCO) measurement, and standardized questionnaires.
RESULTS:Most participants had normal airflow; 18% of HIV-infected and 16% of HIV-uninfected men had airflow obstruction. The mean percent predicted DLCO was 69% in HIV-infected vs. 76% in HIV-uninfected men (P < 0.001). A moderately to severely reduced DLCO of ≤60% was observed in 30% of HIV-infected compared with 18% of HIV-uninfected men (P < 0.001), despite the fact that 89% of those with HIV were on antiretroviral therapy. A reduced DLCO was significantly associated with HIV and CD4 cell count in linear regression adjusting for smoking and other confounders. The DLCO was lowest in HIV-infected men with CD4 cell counts |
| doi_str_mv | 10.1097/QAI.0b013e3182a9215a |
| format | Article |
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OBJECTIVES:To determine the pattern and severity of impairment in pulmonary function in HIV-infected compared with HIV-uninfected individuals.
METHODS:Cross-sectional analysis of 300 HIV-infected men and 289 HIV-uninfected men enrolled from 2009 to 2011 in 2 clinical centers of the Lung HIV Study. Participants completed pre- and postbronchodilator spirometry, diffusing capacity of the lung for carbon monoxide (DLCO) measurement, and standardized questionnaires.
RESULTS:Most participants had normal airflow; 18% of HIV-infected and 16% of HIV-uninfected men had airflow obstruction. The mean percent predicted DLCO was 69% in HIV-infected vs. 76% in HIV-uninfected men (P < 0.001). A moderately to severely reduced DLCO of ≤60% was observed in 30% of HIV-infected compared with 18% of HIV-uninfected men (P < 0.001), despite the fact that 89% of those with HIV were on antiretroviral therapy. A reduced DLCO was significantly associated with HIV and CD4 cell count in linear regression adjusting for smoking and other confounders. The DLCO was lowest in HIV-infected men with CD4 cell counts <200 cells per microliter compared with those with CD4 cell counts ≥200 cells per microliter and to HIV-uninfected men. Respiratory symptoms of cough, phlegm and dyspnea were more prevalent in HIV-infected patients particularly those with abnormal pulmonary function compared with HIV-uninfected patients.
CONCLUSIONS:HIV infection is an independent risk factor for reduced DLCO, particularly in individuals with a CD4 cell count below 200 cells per microliter. Abnormalities in pulmonary function among HIV-infected patients manifest clinically with increased respiratory symptoms. Mechanisms accounting for the reduced DLCO require further evaluation.</description><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/QAI.0b013e3182a9215a</identifier><identifier>PMID: 23979001</identifier><identifier>CODEN: JDSRET</identifier><language>eng</language><publisher>Hagerstown, MD: by Lippincott Williams & Wilkins</publisher><subject>Age Factors ; Biological and medical sciences ; CD4 Lymphocyte Count ; Cough - etiology ; Cough - physiopathology ; Cross-Sectional Studies ; Dyspnea - etiology ; Dyspnea - physiopathology ; Fundamental and applied biological sciences. Psychology ; HIV ; HIV Infections - complications ; HIV Infections - physiopathology ; HIV Infections - virology ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Longitudinal Studies ; Lung diseases ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Prevalence ; Pulmonary Diffusing Capacity ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Pulmonary Disease, Chronic Obstructive - etiology ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Disease, Chronic Obstructive - virology ; Respiratory Function Tests ; Risk Factors ; Severity of Illness Index ; Smoking - adverse effects ; Smoking - epidemiology ; Surveys and Questionnaires ; United States - epidemiology ; Veterans ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; Virology</subject><ispartof>Journal of acquired immune deficiency syndromes (1999), 2013-11, Vol.64 (3), p.271-278</ispartof><rights>2013 by Lippincott Williams & Wilkins</rights><rights>2014 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Nov 1, 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548a-eee8d52d541e1115ed4cde1e6b71dde4153435a4e0c8c5ce5b3627e9956f01643</citedby><cites>FETCH-LOGICAL-c548a-eee8d52d541e1115ed4cde1e6b71dde4153435a4e0c8c5ce5b3627e9956f01643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27860767$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23979001$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crothers, Kristina</creatorcontrib><creatorcontrib>McGinnis, Kathleen</creatorcontrib><creatorcontrib>Kleerup, Eric</creatorcontrib><creatorcontrib>Wongtrakool, Cherry</creatorcontrib><creatorcontrib>Hoo, Guy S</creatorcontrib><creatorcontrib>Kim, Joon</creatorcontrib><creatorcontrib>Sharafkhaneh, Amir</creatorcontrib><creatorcontrib>Huang, Laurence</creatorcontrib><creatorcontrib>Luo, Zhaoyu</creatorcontrib><creatorcontrib>Thompson, Bruce</creatorcontrib><creatorcontrib>Diaz, Philip</creatorcontrib><creatorcontrib>Kirk, Gregory D</creatorcontrib><creatorcontrib>Rom, William</creatorcontrib><creatorcontrib>Detels, Roger</creatorcontrib><creatorcontrib>Kingsley, Lawrence</creatorcontrib><creatorcontrib>Morris, Alison</creatorcontrib><title>HIV Infection Is Associated With Reduced Pulmonary Diffusing Capacity</title><title>Journal of acquired immune deficiency syndromes (1999)</title><addtitle>J Acquir Immune Defic Syndr</addtitle><description>INTRODUCTION:Prior studies comparing abnormalities in pulmonary function between HIV-infected and HIV-uninfected persons in the current era are limited.
OBJECTIVES:To determine the pattern and severity of impairment in pulmonary function in HIV-infected compared with HIV-uninfected individuals.
METHODS:Cross-sectional analysis of 300 HIV-infected men and 289 HIV-uninfected men enrolled from 2009 to 2011 in 2 clinical centers of the Lung HIV Study. Participants completed pre- and postbronchodilator spirometry, diffusing capacity of the lung for carbon monoxide (DLCO) measurement, and standardized questionnaires.
RESULTS:Most participants had normal airflow; 18% of HIV-infected and 16% of HIV-uninfected men had airflow obstruction. The mean percent predicted DLCO was 69% in HIV-infected vs. 76% in HIV-uninfected men (P < 0.001). A moderately to severely reduced DLCO of ≤60% was observed in 30% of HIV-infected compared with 18% of HIV-uninfected men (P < 0.001), despite the fact that 89% of those with HIV were on antiretroviral therapy. A reduced DLCO was significantly associated with HIV and CD4 cell count in linear regression adjusting for smoking and other confounders. The DLCO was lowest in HIV-infected men with CD4 cell counts <200 cells per microliter compared with those with CD4 cell counts ≥200 cells per microliter and to HIV-uninfected men. Respiratory symptoms of cough, phlegm and dyspnea were more prevalent in HIV-infected patients particularly those with abnormal pulmonary function compared with HIV-uninfected patients.
CONCLUSIONS:HIV infection is an independent risk factor for reduced DLCO, particularly in individuals with a CD4 cell count below 200 cells per microliter. Abnormalities in pulmonary function among HIV-infected patients manifest clinically with increased respiratory symptoms. Mechanisms accounting for the reduced DLCO require further evaluation.</description><subject>Age Factors</subject><subject>Biological and medical sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>Cough - etiology</subject><subject>Cough - physiopathology</subject><subject>Cross-Sectional Studies</subject><subject>Dyspnea - etiology</subject><subject>Dyspnea - physiopathology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - physiopathology</subject><subject>HIV Infections - virology</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Longitudinal Studies</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Prevalence</subject><subject>Pulmonary Diffusing Capacity</subject><subject>Pulmonary Disease, Chronic Obstructive - epidemiology</subject><subject>Pulmonary Disease, Chronic Obstructive - etiology</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary Disease, Chronic Obstructive - virology</subject><subject>Respiratory Function Tests</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Smoking - adverse effects</subject><subject>Smoking - epidemiology</subject><subject>Surveys and Questionnaires</subject><subject>United States - epidemiology</subject><subject>Veterans</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Load</subject><subject>Virology</subject><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVtr3DAQRk1paC7tPyjFUAp5caqx7i-FZZs0hkAv9PIotPI4q9RrbSQ7If--WnaTtnkofZIGnRnO6CuKl0BOgGj59vOsOSELAhQpqNrqGrh9UhyAZqySSrGn-c5rXjGgfL84TOmKEBCM6WfFfk211Lk8KE7Pm-9lM3ToRh-GsknlLKXgvB2xLX_4cVl-wXZyufg09asw2HhXvvddNyU_XJZzu7bOj3fPi73O9glf7M6j4tvZ6df5eXXx8UMzn11UjjNlK0RULa9bzgABgGPLXIuAYiGhbZEBp4xyy5A45bhDvqCilqg1F93GnR4V77Zz19Niha3DYYy2N-voV1nMBOvN3y-DX5rLcGOoYlxJnQcc7wbEcD1hGs3KJ4d9bwcMUzKQMU45_BfKKM1mSmb09SP0KkxxyD-xoZgQHATJFNtSLoaUInYP3kDMJlKTIzWPI81tr_7c-aHpPsMMvNkBNjnbd9EOzqffnFSCSLGxVFvuNvQjxvSzn24xmiXaflz-2-EXnhe7iA</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Crothers, Kristina</creator><creator>McGinnis, Kathleen</creator><creator>Kleerup, Eric</creator><creator>Wongtrakool, Cherry</creator><creator>Hoo, Guy S</creator><creator>Kim, Joon</creator><creator>Sharafkhaneh, Amir</creator><creator>Huang, Laurence</creator><creator>Luo, Zhaoyu</creator><creator>Thompson, Bruce</creator><creator>Diaz, Philip</creator><creator>Kirk, Gregory D</creator><creator>Rom, William</creator><creator>Detels, Roger</creator><creator>Kingsley, Lawrence</creator><creator>Morris, Alison</creator><general>by Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>7U1</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>20131101</creationdate><title>HIV Infection Is Associated With Reduced Pulmonary Diffusing Capacity</title><author>Crothers, Kristina ; McGinnis, Kathleen ; Kleerup, Eric ; Wongtrakool, Cherry ; Hoo, Guy S ; Kim, Joon ; Sharafkhaneh, Amir ; Huang, Laurence ; Luo, Zhaoyu ; Thompson, Bruce ; Diaz, Philip ; Kirk, Gregory D ; Rom, William ; Detels, Roger ; Kingsley, Lawrence ; Morris, Alison</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548a-eee8d52d541e1115ed4cde1e6b71dde4153435a4e0c8c5ce5b3627e9956f01643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age Factors</topic><topic>Biological and medical sciences</topic><topic>CD4 Lymphocyte Count</topic><topic>Cough - etiology</topic><topic>Cough - physiopathology</topic><topic>Cross-Sectional Studies</topic><topic>Dyspnea - etiology</topic><topic>Dyspnea - physiopathology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - physiopathology</topic><topic>HIV Infections - virology</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Longitudinal Studies</topic><topic>Lung diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Prevalence</topic><topic>Pulmonary Diffusing Capacity</topic><topic>Pulmonary Disease, Chronic Obstructive - epidemiology</topic><topic>Pulmonary Disease, Chronic Obstructive - etiology</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary Disease, Chronic Obstructive - virology</topic><topic>Respiratory Function Tests</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Smoking - adverse effects</topic><topic>Smoking - epidemiology</topic><topic>Surveys and Questionnaires</topic><topic>United States - epidemiology</topic><topic>Veterans</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Load</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crothers, Kristina</creatorcontrib><creatorcontrib>McGinnis, Kathleen</creatorcontrib><creatorcontrib>Kleerup, Eric</creatorcontrib><creatorcontrib>Wongtrakool, Cherry</creatorcontrib><creatorcontrib>Hoo, Guy S</creatorcontrib><creatorcontrib>Kim, Joon</creatorcontrib><creatorcontrib>Sharafkhaneh, Amir</creatorcontrib><creatorcontrib>Huang, Laurence</creatorcontrib><creatorcontrib>Luo, Zhaoyu</creatorcontrib><creatorcontrib>Thompson, Bruce</creatorcontrib><creatorcontrib>Diaz, Philip</creatorcontrib><creatorcontrib>Kirk, Gregory D</creatorcontrib><creatorcontrib>Rom, William</creatorcontrib><creatorcontrib>Detels, Roger</creatorcontrib><creatorcontrib>Kingsley, Lawrence</creatorcontrib><creatorcontrib>Morris, Alison</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crothers, Kristina</au><au>McGinnis, Kathleen</au><au>Kleerup, Eric</au><au>Wongtrakool, Cherry</au><au>Hoo, Guy S</au><au>Kim, Joon</au><au>Sharafkhaneh, Amir</au><au>Huang, Laurence</au><au>Luo, Zhaoyu</au><au>Thompson, Bruce</au><au>Diaz, Philip</au><au>Kirk, Gregory D</au><au>Rom, William</au><au>Detels, Roger</au><au>Kingsley, Lawrence</au><au>Morris, Alison</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HIV Infection Is Associated With Reduced Pulmonary Diffusing Capacity</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><addtitle>J Acquir Immune Defic Syndr</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>64</volume><issue>3</issue><spage>271</spage><epage>278</epage><pages>271-278</pages><issn>1525-4135</issn><eissn>1944-7884</eissn><coden>JDSRET</coden><abstract>INTRODUCTION:Prior studies comparing abnormalities in pulmonary function between HIV-infected and HIV-uninfected persons in the current era are limited.
OBJECTIVES:To determine the pattern and severity of impairment in pulmonary function in HIV-infected compared with HIV-uninfected individuals.
METHODS:Cross-sectional analysis of 300 HIV-infected men and 289 HIV-uninfected men enrolled from 2009 to 2011 in 2 clinical centers of the Lung HIV Study. Participants completed pre- and postbronchodilator spirometry, diffusing capacity of the lung for carbon monoxide (DLCO) measurement, and standardized questionnaires.
RESULTS:Most participants had normal airflow; 18% of HIV-infected and 16% of HIV-uninfected men had airflow obstruction. The mean percent predicted DLCO was 69% in HIV-infected vs. 76% in HIV-uninfected men (P < 0.001). A moderately to severely reduced DLCO of ≤60% was observed in 30% of HIV-infected compared with 18% of HIV-uninfected men (P < 0.001), despite the fact that 89% of those with HIV were on antiretroviral therapy. A reduced DLCO was significantly associated with HIV and CD4 cell count in linear regression adjusting for smoking and other confounders. The DLCO was lowest in HIV-infected men with CD4 cell counts <200 cells per microliter compared with those with CD4 cell counts ≥200 cells per microliter and to HIV-uninfected men. Respiratory symptoms of cough, phlegm and dyspnea were more prevalent in HIV-infected patients particularly those with abnormal pulmonary function compared with HIV-uninfected patients.
CONCLUSIONS:HIV infection is an independent risk factor for reduced DLCO, particularly in individuals with a CD4 cell count below 200 cells per microliter. Abnormalities in pulmonary function among HIV-infected patients manifest clinically with increased respiratory symptoms. Mechanisms accounting for the reduced DLCO require further evaluation.</abstract><cop>Hagerstown, MD</cop><pub>by Lippincott Williams & Wilkins</pub><pmid>23979001</pmid><doi>10.1097/QAI.0b013e3182a9215a</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of acquired immune deficiency syndromes (1999), 2013-11, Vol.64 (3), p.271-278 |
| issn | 1525-4135 1944-7884 |
| language | eng |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; Free E- Journals |
| subjects | Age Factors Biological and medical sciences CD4 Lymphocyte Count Cough - etiology Cough - physiopathology Cross-Sectional Studies Dyspnea - etiology Dyspnea - physiopathology Fundamental and applied biological sciences. Psychology HIV HIV Infections - complications HIV Infections - physiopathology HIV Infections - virology Human immunodeficiency virus Human viral diseases Humans Infectious diseases Longitudinal Studies Lung diseases Male Medical sciences Microbiology Middle Aged Miscellaneous Prevalence Pulmonary Diffusing Capacity Pulmonary Disease, Chronic Obstructive - epidemiology Pulmonary Disease, Chronic Obstructive - etiology Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Disease, Chronic Obstructive - virology Respiratory Function Tests Risk Factors Severity of Illness Index Smoking - adverse effects Smoking - epidemiology Surveys and Questionnaires United States - epidemiology Veterans Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virology |
| title | HIV Infection Is Associated With Reduced Pulmonary Diffusing Capacity |
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