Pax3 synergizes with Gli2 and Zic1 in transactivating the Myf5 epaxial somite enhancer

Both Glis, the downstream effectors of hedgehog signaling, and Zic transcription factors are required for Myf5 expression in the epaxial somite. Here we demonstrate a novel synergistic interaction between members of both families and Pax3, a paired-domain transcription factor that is essential for b...

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Veröffentlicht in:	Developmental biology 2013-11, Vol.383 (1), p.7-14
Hauptverfasser:	Himeda, Charis L., Barro, Marietta V., Emerson, Charles P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Chromatin Immunoprecipitation DNA Primers - genetics Electrophoretic Mobility Shift Assay Embryonic Stem Cells - metabolism gene overexpression Gli Immunoprecipitation Kruppel-Like Transcription Factors - metabolism loci Mesenchymal Stromal Cells - metabolism Mice muscle development Myf5 Myogenesis Myogenic Regulatory Factor 5 - metabolism neural crest NIH 3T3 Cells Paired Box Transcription Factors - metabolism Pax PAX3 Transcription Factor proteins Reverse Transcriptase Polymerase Chain Reaction Skeletal muscle Somites - embryology Somites - metabolism transcription factors Transcription Factors - metabolism Transcriptional Activation - physiology Zic Zinc Finger Protein Gli2
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