Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance
The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation, progression, and drug resistance. Recent research shows that FOXM1 is a direct transcriptional target of FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling cascade. In addition, FOXM1 and FOXO3a...
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| Veröffentlicht in: | Ai zheng 2013-07, Vol.32 (7), p.365-370 |
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| creator | Gomes, Ana R Zhao, Fung Lam, Eric W F |
| description | The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation, progression, and drug resistance. Recent research shows that FOXM1 is a direct transcriptional target of FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling cascade. In addition, FOXM1 and FOXO3a also antagonize each other＇s activity by competitively binding to the same target genes, which are involved in chemotherapeutic drug sensitivity and resistance. Understanding the role and regulation of the FOXO-FOXM1 axis will provide insight into chemotherapeutic drug action and resistance in patients, and help to identify novel therapeutic approaches as well as diagnostic and predictive biomarkers. |
| doi_str_mv | 10.5732/cjc.012.10277 |
| format | Article |
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All Rights Reserved.</rights><rights>Chinese Journal of Cancer 2013</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c507t-71c6727bdb4be586d483b16db5520db678fe3af0403bac0ae37cbf4dfc232b463</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/90720X/90720X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845605/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3845605/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23706767$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gomes, Ana R</creatorcontrib><creatorcontrib>Zhao, Fung</creatorcontrib><creatorcontrib>Lam, Eric W F</creatorcontrib><title>Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance</title><title>Ai zheng</title><addtitle>Chinese Journal of Cancer</addtitle><description>The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation, progression, and drug resistance. Recent research shows that FOXM1 is a direct transcriptional target of FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling cascade. In addition, FOXM1 and FOXO3a also antagonize each other＇s activity by competitively binding to the same target genes, which are involved in chemotherapeutic drug sensitivity and resistance. Understanding the role and regulation of the FOXO-FOXM1 axis will provide insight into chemotherapeutic drug action and resistance in patients, and help to identify novel therapeutic approaches as well as diagnostic and predictive biomarkers.</description><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Carcinogenesis - genetics</subject><subject>Carcinogenesis - metabolism</subject><subject>Drug Resistance, Neoplasm</subject><subject>Forkhead Box Protein M1</subject><subject>Forkhead Box Protein O3</subject><subject>Forkhead Transcription Factors - genetics</subject><subject>Forkhead Transcription Factors - metabolism</subject><subject>Humans</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - metabolism</subject><subject>Neoplasms - pathology</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Proto-Oncogene Proteins c-akt - metabolism</subject><subject>Review</subject><subject>Signal Transduction</subject><subject>化疗药物</subject><subject>叉头</subject><subject>敏感性</subject><subject>生物标志物</subject><subject>竞争力</subject><subject>耐药性</subject><subject>致癌性</subject><subject>转录因子</subject><issn>1000-467X</issn><issn>1944-446X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkd1rVDEQxYMotlYffZWIz3edfN--CFKsCpUFUdi3kM-7WbfJmtxV6l_fuNsWfcqE85szMxyEXhJYCMXoW7dxCyB0QYAq9QidknPOB87l6nGvAWDgUq1O0LPWNgCcnKvxKTqhTIFUUp2i3deyDdhkj2uY9lszp5JxiXheBxxL_bEOxuO5mtxcTbuDGo2bS234crlaMnPo7eUXglPGzlSXcplCDi21g-brfurm_Tub7MJz9CSabQsv7t4z9P3yw7eLT8PV8uPni_dXgxOg5kERJxVV1ltugxil5yOzRHorBAVvpRpjYCYCB2aNAxOYcjZyHx1l1HLJztC7o-9ub6-DdyH3K7Z6V9O1qTe6mKT_V3Ja66n80mzkQoLoBm-OBr9NjiZPelP2NfeVdfhDgTBQAKxTw5FytbRWQ3yYQED_DUj3gHQPSB8C6vyrf9d6oO8T6cDrO8N1ydPP1AffM1wKoSRIdgurNJl8</recordid><startdate>20130701</startdate><enddate>20130701</enddate><creator>Gomes, Ana R</creator><creator>Zhao, Fung</creator><creator>Lam, Eric W F</creator><general>Department of Surgery and Cancer, Imperial Col ege London, Hammersmith Hospital Campus, London, W12 0NN, United Kingdom</general><general>Sun Yat-sen University Cancer Center</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20130701</creationdate><title>Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance</title><author>Gomes, Ana R ; Zhao, Fung ; Lam, Eric W F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c507t-71c6727bdb4be586d483b16db5520db678fe3af0403bac0ae37cbf4dfc232b463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antineoplastic Agents - pharmacology</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Carcinogenesis - genetics</topic><topic>Carcinogenesis - metabolism</topic><topic>Drug Resistance, Neoplasm</topic><topic>Forkhead Box Protein M1</topic><topic>Forkhead Box Protein O3</topic><topic>Forkhead Transcription Factors - genetics</topic><topic>Forkhead Transcription Factors - metabolism</topic><topic>Humans</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - metabolism</topic><topic>Neoplasms - pathology</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Proto-Oncogene Proteins c-akt - metabolism</topic><topic>Review</topic><topic>Signal Transduction</topic><topic>化疗药物</topic><topic>叉头</topic><topic>敏感性</topic><topic>生物标志物</topic><topic>竞争力</topic><topic>耐药性</topic><topic>致癌性</topic><topic>转录因子</topic><toplevel>online_resources</toplevel><creatorcontrib>Gomes, Ana R</creatorcontrib><creatorcontrib>Zhao, Fung</creatorcontrib><creatorcontrib>Lam, Eric W F</creatorcontrib><collection>维普_期刊</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>维普中文期刊数据库</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Ai zheng</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gomes, Ana R</au><au>Zhao, Fung</au><au>Lam, Eric W F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance</atitle><jtitle>Ai zheng</jtitle><addtitle>Chinese Journal of Cancer</addtitle><date>2013-07-01</date><risdate>2013</risdate><volume>32</volume><issue>7</issue><spage>365</spage><epage>370</epage><pages>365-370</pages><issn>1000-467X</issn><eissn>1944-446X</eissn><abstract>The FOXO3a and FOXM1 forkhead transcription factors are key players in cancer initiation, progression, and drug resistance. Recent research shows that FOXM1 is a direct transcriptional target of FOXO3a, a vital downstream effector of the PI3K-AKT-FOXO signaling cascade. In addition, FOXM1 and FOXO3a also antagonize each other＇s activity by competitively binding to the same target genes, which are involved in chemotherapeutic drug sensitivity and resistance. Understanding the role and regulation of the FOXO-FOXM1 axis will provide insight into chemotherapeutic drug action and resistance in patients, and help to identify novel therapeutic approaches as well as diagnostic and predictive biomarkers.</abstract><cop>England</cop><pub>Department of Surgery and Cancer, Imperial Col ege London, Hammersmith Hospital Campus, London, W12 0NN, United Kingdom</pub><pmid>23706767</pmid><doi>10.5732/cjc.012.10277</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Carcinogenesis - genetics Carcinogenesis - metabolism Drug Resistance, Neoplasm Forkhead Box Protein M1 Forkhead Box Protein O3 Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Humans Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Review Signal Transduction 化疗药物 叉头 敏感性 生物标志物 竞争力 耐药性 致癌性 转录因子 |
| title | Role and regulation of the forkhead transcription factors FOXO3a and FOXM1 in carcinogenesis and drug resistance |
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