Prior TLR5 induction in human T cells results in a transient potentiation of subsequent TCR-induced cytokine production

•Activation of TLR5, but not TLR2, potentiates ensuing TCR-induced cytokine release.•The effects of TLR5 on TCR-mediated cytokine production lasts for 24–36h.•Prior TLR5 induction enhances TCR-mediated AKT activation.•TLR5 pretreatments suppresses TCR-induced Lck and LAT induction. Activation of TLR...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular immunology 2014-02, Vol.57 (2), p.161-170
Hauptverfasser:	Tremblay, Mikaela M., Bilal, Mahmood Y., Houtman, Jon C.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Cell Line Cytokines - biosynthesis Extracellular Signal-Regulated MAP Kinases - metabolism Flagellin - immunology Humans Interleukin-1 Receptor-Associated Kinases - antagonists & inhibitors Interleukin-1 Receptor-Associated Kinases - metabolism Lymphocyte Activation - immunology Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Membrane Proteins - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Receptors, Antigen, T-Cell - immunology Signal Transduction T cell receptor T cells T-Lymphocytes - immunology T-Lymphocytes - metabolism Toll-Like Receptor 2 - metabolism Toll-like receptor 5 Toll-Like Receptor 5 - biosynthesis Toll-Like Receptor 5 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!