Presynaptic and Postsynaptic Amplifications of Neuropathic Pain in the Anterior Cingulate Cortex
Neuropathic pain is caused by a primary lesion or dysfunction in the nervous system. Investigations have mainly focused on the spinal mechanisms of neuropathic pain, and less is known about cortical changes in neuropathic pain. Here, we report that peripheral nerve injury triggered long-term changes...
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| Veröffentlicht in: | The Journal of neuroscience 2008-07, Vol.28 (29), p.7445-7453 |
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| creator | Xu, Hui Wu, Long-Jun Wang, Hansen Zhang, Xuehan Vadakkan, Kunjumon I Kim, Susan S Steenland, Hendrik W Zhuo, Min |
| description | Neuropathic pain is caused by a primary lesion or dysfunction in the nervous system. Investigations have mainly focused on the spinal mechanisms of neuropathic pain, and less is known about cortical changes in neuropathic pain. Here, we report that peripheral nerve injury triggered long-term changes in excitatory synaptic transmission in layer II/III neurons within the anterior cingulate cortex (ACC). Both the presynaptic release probability of glutamate and postsynaptic glutamate AMPA receptor-mediated responses were enhanced after injury using the mouse peripheral nerve injury model. Western blot showed upregulated phosphorylation of GluR1 in the ACC after nerve injury. Finally, we found that both presynaptic and postsynaptic changes after nerve injury were absent in genetic mice lacking calcium-stimulated adenylyl cyclase 1 (AC1). Our studies therefore provide direct integrative evidence for both long-term presynaptic and postsynaptic changes in cortical synapses after nerve injury, and that AC1 is critical for such long-term changes. AC1 thus may serve as a potential therapeutic target for treating neuropathic pain. |
| doi_str_mv | 10.1523/JNEUROSCI.1812-08.2008 |
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| subjects | Animals Behavior, Animal - physiology Disease Models, Animal Excitatory Postsynaptic Potentials - genetics Excitatory Postsynaptic Potentials - physiology Gyrus Cinguli - physiology Ligation Male Mice Mice, Inbred C57BL Mice, Knockout Pain - genetics Pain - physiopathology Peroneal Nerve Presynaptic Terminals - physiology Synaptic Transmission - genetics Synaptic Transmission - physiology |
| title | Presynaptic and Postsynaptic Amplifications of Neuropathic Pain in the Anterior Cingulate Cortex |
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