Atherosclerosis and interferon-γ: New insights and therapeutic targets

Abstract Atherosclerosis is considered to be a chronic inflammatory disease of the arterial wall. Atherogenesis is accompanied by local production and release of inflammatory mediators, for which the macrophage is a major source. The proinflammatory cytokine, interferon (IFN)-γ derived from T cells,...

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Veröffentlicht in:	Trends in cardiovascular medicine 2014-01, Vol.24 (1), p.45-51
Hauptverfasser:	Voloshyna, Iryna, Littlefield, Michael J, Reiss, Allison B
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - therapeutic use Atherosclerosis - drug therapy Atherosclerosis - immunology Atherosclerosis - metabolism Cardiovascular Cardiovascular Agents - therapeutic use Drug Design Humans Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - metabolism Interferon-gamma - antagonists & inhibitors Interferon-gamma - metabolism Molecular Targeted Therapy Signal Transduction - drug effects
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