Investigation of serum protein profiles in scrapie infected sheep by means of SELDI-TOF-MS and multivariate data analysis

Classical scrapie in sheep is a fatal neurodegenerative disease associated with the conversion PrPC to PrPSc. Much is known about genetic susceptibility, uptake and dissemination of PrPSc in the body, but many aspects of prion diseases are still unknown. Different proteomic techniques have been used...

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Veröffentlicht in:	BMC research notes 2013-11, Vol.6 (1), p.466-466, Article 466
Hauptverfasser:	Meling, Siv, Kvalheim, Olav M, Arneberg, Reidar, Bårdsen, Kjetil, Hjelle, Anne, Ulvund, Martha J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amyloid Analysis Animals Animals, Newborn Blood proteins Chromatography, Liquid Disease susceptibility Least-Squares Analysis Molecular Sequence Data Multivariate Analysis Principal Component Analysis Prion diseases Proteome - chemistry Proteome - metabolism Proteomics PrPSc Proteins - blood PrPSc Proteins - chemistry Scrapie Scrapie - blood Serum Amyloid A Protein - chemistry Serum Amyloid A Protein - metabolism Sheep Sheep, Domestic Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tandem Mass Spectrometry
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