Neonatal Mortality in HIV-Exposed Infants Born to Women Receiving Combination Antiretroviral Therapy in Rural Uganda
As human immunodeficiency virus (HIV)-infected women gain access to combination antiretroviral therapy throughout sub-Saharan Africa, a growing number of infants are being born HIV-exposed but uninfected. Data about neonatal mortality and the impact of premature delivery, in this population are limi...
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| Veröffentlicht in: | Journal of tropical pediatrics (1980) 2013-12, Vol.59 (6), p.441-446 |
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| container_title | Journal of tropical pediatrics (1980) |
| container_volume | 59 |
| creator | ADES, Veronica MWESIGWA, Julia RUEL, Theodore D NATUREEBA, Paul CLARK, Tamara D PLENTY, Albert CHARLEBOIS, Edwin ACHAN, Jane KAMYA, Moses R HAVLIR, Diane V COHAN, Deborah |
| description | As human immunodeficiency virus (HIV)-infected women gain access to combination antiretroviral therapy throughout sub-Saharan Africa, a growing number of infants are being born HIV-exposed but uninfected. Data about neonatal mortality and the impact of premature delivery, in this population are limited. We describe the 28-day mortality outcomes in a cohort of HIV-exposed infants who had ultrasound-confirmed gestational age in rural Uganda. There were 13 deaths among 351 infants, including 9 deaths in the perinatal period. Premature delivery was a strong predictor of mortality. The prevention of HIV transmission to infants is now possible in rural low-resource settings but the frequency of neonatal death among HIV-exposed infants remains extremely high, calling for new comprehensive interventions to reduce mortality in this growing population. |
| doi_str_mv | 10.1093/tropej/fmt044 |
| format | Article |
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Data about neonatal mortality and the impact of premature delivery, in this population are limited. We describe the 28-day mortality outcomes in a cohort of HIV-exposed infants who had ultrasound-confirmed gestational age in rural Uganda. There were 13 deaths among 351 infants, including 9 deaths in the perinatal period. Premature delivery was a strong predictor of mortality. The prevention of HIV transmission to infants is now possible in rural low-resource settings but the frequency of neonatal death among HIV-exposed infants remains extremely high, calling for new comprehensive interventions to reduce mortality in this growing population.</description><identifier>ISSN: 0142-6338</identifier><identifier>ISSN: 1465-3664</identifier><identifier>EISSN: 1465-3664</identifier><identifier>DOI: 10.1093/tropej/fmt044</identifier><identifier>PMID: 23764539</identifier><identifier>CODEN: JTRPAO</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Adult ; Anti-Retroviral Agents - adverse effects ; Anti-Retroviral Agents - therapeutic use ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiretroviral Therapy, Highly Active - adverse effects ; Antiviral agents ; Biological and medical sciences ; Female ; Follow-Up Studies ; General aspects ; Gestational Age ; HIV Infections - diagnosis ; HIV Infections - drug therapy ; HIV Infections - prevention & control ; HIV Infections - transmission ; HIV-1 ; Human viral diseases ; Humans ; Infant ; Infant Mortality ; Infant, Premature ; Infectious Disease Transmission, Vertical - prevention & control ; Infectious diseases ; Male ; Medical sciences ; Original Papers ; Pharmacology. Drug treatments ; Pregnancy ; Pregnancy Complications, Infectious - diagnosis ; Pregnancy Complications, Infectious - drug therapy ; Pregnancy Outcome ; Premature Birth ; Prospective Studies ; Rural Population - statistics & numerical data ; Survival Analysis ; Treatment Outcome ; Uganda - epidemiology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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Data about neonatal mortality and the impact of premature delivery, in this population are limited. We describe the 28-day mortality outcomes in a cohort of HIV-exposed infants who had ultrasound-confirmed gestational age in rural Uganda. There were 13 deaths among 351 infants, including 9 deaths in the perinatal period. Premature delivery was a strong predictor of mortality. The prevention of HIV transmission to infants is now possible in rural low-resource settings but the frequency of neonatal death among HIV-exposed infants remains extremely high, calling for new comprehensive interventions to reduce mortality in this growing population.</description><subject>Adult</subject><subject>Anti-Retroviral Agents - adverse effects</subject><subject>Anti-Retroviral Agents - therapeutic use</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiretroviral Therapy, Highly Active - adverse effects</subject><subject>Antiviral agents</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>General aspects</subject><subject>Gestational Age</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - prevention & control</subject><subject>HIV Infections - transmission</subject><subject>HIV-1</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant Mortality</subject><subject>Infant, Premature</subject><subject>Infectious Disease Transmission, Vertical - prevention & control</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Original Papers</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Infectious - diagnosis</subject><subject>Pregnancy Complications, Infectious - drug therapy</subject><subject>Pregnancy Outcome</subject><subject>Premature Birth</subject><subject>Prospective Studies</subject><subject>Rural Population - statistics & numerical data</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><subject>Uganda - epidemiology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antiretroviral Therapy, Highly Active - adverse effects</topic><topic>Antiviral agents</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>General aspects</topic><topic>Gestational Age</topic><topic>HIV Infections - diagnosis</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - prevention & control</topic><topic>HIV Infections - transmission</topic><topic>HIV-1</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant Mortality</topic><topic>Infant, Premature</topic><topic>Infectious Disease Transmission, Vertical - prevention & control</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Original Papers</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Infectious - diagnosis</topic><topic>Pregnancy Complications, Infectious - drug therapy</topic><topic>Pregnancy Outcome</topic><topic>Premature Birth</topic><topic>Prospective Studies</topic><topic>Rural Population - statistics & numerical data</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><topic>Uganda - epidemiology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ADES, Veronica</creatorcontrib><creatorcontrib>MWESIGWA, Julia</creatorcontrib><creatorcontrib>RUEL, Theodore D</creatorcontrib><creatorcontrib>NATUREEBA, Paul</creatorcontrib><creatorcontrib>CLARK, Tamara D</creatorcontrib><creatorcontrib>PLENTY, Albert</creatorcontrib><creatorcontrib>CHARLEBOIS, Edwin</creatorcontrib><creatorcontrib>ACHAN, Jane</creatorcontrib><creatorcontrib>KAMYA, Moses R</creatorcontrib><creatorcontrib>HAVLIR, Diane V</creatorcontrib><creatorcontrib>COHAN, Deborah</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of tropical pediatrics (1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ADES, Veronica</au><au>MWESIGWA, Julia</au><au>RUEL, Theodore D</au><au>NATUREEBA, Paul</au><au>CLARK, Tamara D</au><au>PLENTY, Albert</au><au>CHARLEBOIS, Edwin</au><au>ACHAN, Jane</au><au>KAMYA, Moses R</au><au>HAVLIR, Diane V</au><au>COHAN, Deborah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal Mortality in HIV-Exposed Infants Born to Women Receiving Combination Antiretroviral Therapy in Rural Uganda</atitle><jtitle>Journal of tropical pediatrics (1980)</jtitle><addtitle>J Trop Pediatr</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>59</volume><issue>6</issue><spage>441</spage><epage>446</epage><pages>441-446</pages><issn>0142-6338</issn><issn>1465-3664</issn><eissn>1465-3664</eissn><coden>JTRPAO</coden><abstract>As human immunodeficiency virus (HIV)-infected women gain access to combination antiretroviral therapy throughout sub-Saharan Africa, a growing number of infants are being born HIV-exposed but uninfected. Data about neonatal mortality and the impact of premature delivery, in this population are limited. We describe the 28-day mortality outcomes in a cohort of HIV-exposed infants who had ultrasound-confirmed gestational age in rural Uganda. There were 13 deaths among 351 infants, including 9 deaths in the perinatal period. Premature delivery was a strong predictor of mortality. The prevention of HIV transmission to infants is now possible in rural low-resource settings but the frequency of neonatal death among HIV-exposed infants remains extremely high, calling for new comprehensive interventions to reduce mortality in this growing population.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>23764539</pmid><doi>10.1093/tropej/fmt044</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0142-6338 |
| ispartof | Journal of tropical pediatrics (1980), 2013-12, Vol.59 (6), p.441-446 |
| issn | 0142-6338 1465-3664 1465-3664 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3842848 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Anti-Retroviral Agents - adverse effects Anti-Retroviral Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active - adverse effects Antiviral agents Biological and medical sciences Female Follow-Up Studies General aspects Gestational Age HIV Infections - diagnosis HIV Infections - drug therapy HIV Infections - prevention & control HIV Infections - transmission HIV-1 Human viral diseases Humans Infant Infant Mortality Infant, Premature Infectious Disease Transmission, Vertical - prevention & control Infectious diseases Male Medical sciences Original Papers Pharmacology. Drug treatments Pregnancy Pregnancy Complications, Infectious - diagnosis Pregnancy Complications, Infectious - drug therapy Pregnancy Outcome Premature Birth Prospective Studies Rural Population - statistics & numerical data Survival Analysis Treatment Outcome Uganda - epidemiology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids |
| title | Neonatal Mortality in HIV-Exposed Infants Born to Women Receiving Combination Antiretroviral Therapy in Rural Uganda |
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