Adenosine A2A receptor antagonist istradefylline reduces daily OFF time in Parkinson's disease

ABSTRACT Background We evaluated the efficacy and safety of istradefylline, a selective adenosine A2A receptor antagonist administered as adjunctive treatment to levodopa for 12 weeks in a double‐blind manner in Parkinson's disease patients with motor complications in Japan. Methods A total of...

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Veröffentlicht in:	Movement disorders 2013-07, Vol.28 (8), p.1138-1141
Hauptverfasser:	Mizuno, Yoshikuni, Kondo, Tomoyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine A2 Receptor Antagonists - therapeutic use Aged Brief Reports Dose-Response Relationship, Drug Double-Blind Method Female Humans istradefylline Japan levodopa Male Middle Aged motor complications Movement disorders Parkinson Disease - drug therapy Parkinson's disease Purines - therapeutic use Retrospective Studies Treatment Outcome wearing-off
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