Benign metastasizing leiomyoma of the lung
Benign leiomyomas of the uterus are uncommonly found in association with benign smooth muscle tumors beyond the confines of the uterus. Benign metastasizing leiomyoma (BML) is a rare disease in which the lung is described to be the most afflicted extrauterine organ. We present a brief review of the...
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| Veröffentlicht in: | World journal of surgical oncology 2013-10, Vol.11 (1), p.279-279, Article 279 |
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| creator | Ki, Eun Young Hwang, Seon Jeong Lee, Keun Ho Park, Jong Sup Hur, Soo Young |
| description | Benign leiomyomas of the uterus are uncommonly found in association with benign smooth muscle tumors beyond the confines of the uterus. Benign metastasizing leiomyoma (BML) is a rare disease in which the lung is described to be the most afflicted extrauterine organ. We present a brief review of the literature, along with case reports for four patients who were followed up after resection of a pulmonary lesion or after pathological confirmation by biopsy. The clinical course of BML varies from chronic asymptomatic appearance to rapid progression, leading to respiratory failure and death. Our BML patients did not complain of pulmonary symptoms, such as cough, dyspnea, or chest tightness. Pathology revealed benign leiomyomas with no atypia and mitotic activity |
| doi_str_mv | 10.1186/1477-7819-11-279 |
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Benign metastasizing leiomyoma (BML) is a rare disease in which the lung is described to be the most afflicted extrauterine organ. We present a brief review of the literature, along with case reports for four patients who were followed up after resection of a pulmonary lesion or after pathological confirmation by biopsy. The clinical course of BML varies from chronic asymptomatic appearance to rapid progression, leading to respiratory failure and death. Our BML patients did not complain of pulmonary symptoms, such as cough, dyspnea, or chest tightness. Pathology revealed benign leiomyomas with no atypia and mitotic activity <5 per 10 high-power field. Immunohistochemical staining was positive for actin and desmin. A standard treatment for BML has not yet been established. Because of the hormone-sensitive characteristics of BML, treatments are based on hormonal manipulation along with either surgical or medical oophorectomy. Benign metastasizing leiomyoma can be observed in postmenopausal women. We observed four patients who did not receive adjuvant hormonal therapy because they were postmenopausal or perimenopausal. All patients are still healthy and show no evidence of recurrence or progression of the disease.</description><identifier>ISSN: 1477-7819</identifier><identifier>EISSN: 1477-7819</identifier><identifier>DOI: 10.1186/1477-7819-11-279</identifier><identifier>PMID: 24134076</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Care and treatment ; Case Report ; Case studies ; Development and progression ; Diagnosis ; Female ; Humans ; Immunoenzyme Techniques ; Immunohistochemistry ; Leiomyoma ; Leiomyoma - pathology ; Leiomyoma - surgery ; Lung diseases ; Lung Neoplasms - secondary ; Lung Neoplasms - surgery ; Middle Aged ; Muscle proteins ; Patient outcomes ; Postmenopausal women ; Prognosis ; Risk factors ; Tomography, X-Ray Computed ; Uterine Neoplasms - pathology ; Uterine Neoplasms - surgery</subject><ispartof>World journal of surgical oncology, 2013-10, Vol.11 (1), p.279-279, Article 279</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Ki et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Ki et al.; licensee BioMed Central Ltd. 2013 Ki et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b648t-b4139bbebe8da82276cec974bb2b578007fe4989d788814b8805702e7cd79173</citedby><cites>FETCH-LOGICAL-b648t-b4139bbebe8da82276cec974bb2b578007fe4989d788814b8805702e7cd79173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842688/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842688/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24134076$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ki, Eun Young</creatorcontrib><creatorcontrib>Hwang, Seon Jeong</creatorcontrib><creatorcontrib>Lee, Keun Ho</creatorcontrib><creatorcontrib>Park, Jong Sup</creatorcontrib><creatorcontrib>Hur, Soo Young</creatorcontrib><title>Benign metastasizing leiomyoma of the lung</title><title>World journal of surgical oncology</title><addtitle>World J Surg Oncol</addtitle><description>Benign leiomyomas of the uterus are uncommonly found in association with benign smooth muscle tumors beyond the confines of the uterus. Benign metastasizing leiomyoma (BML) is a rare disease in which the lung is described to be the most afflicted extrauterine organ. We present a brief review of the literature, along with case reports for four patients who were followed up after resection of a pulmonary lesion or after pathological confirmation by biopsy. The clinical course of BML varies from chronic asymptomatic appearance to rapid progression, leading to respiratory failure and death. Our BML patients did not complain of pulmonary symptoms, such as cough, dyspnea, or chest tightness. Pathology revealed benign leiomyomas with no atypia and mitotic activity <5 per 10 high-power field. Immunohistochemical staining was positive for actin and desmin. A standard treatment for BML has not yet been established. Because of the hormone-sensitive characteristics of BML, treatments are based on hormonal manipulation along with either surgical or medical oophorectomy. Benign metastasizing leiomyoma can be observed in postmenopausal women. We observed four patients who did not receive adjuvant hormonal therapy because they were postmenopausal or perimenopausal. All patients are still healthy and show no evidence of recurrence or progression of the disease.</description><subject>Care and treatment</subject><subject>Case Report</subject><subject>Case studies</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Immunohistochemistry</subject><subject>Leiomyoma</subject><subject>Leiomyoma - pathology</subject><subject>Leiomyoma - surgery</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - secondary</subject><subject>Lung Neoplasms - surgery</subject><subject>Middle Aged</subject><subject>Muscle proteins</subject><subject>Patient outcomes</subject><subject>Postmenopausal women</subject><subject>Prognosis</subject><subject>Risk factors</subject><subject>Tomography, X-Ray Computed</subject><subject>Uterine Neoplasms - pathology</subject><subject>Uterine Neoplasms - surgery</subject><issn>1477-7819</issn><issn>1477-7819</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNptUl1rHCEUlZLSfPW9T2EgEEJhEh1ddV4K6dImhUBe8i7q3Jk1OJqMM4Xk19dhk2W3LApe7j3nXD1ehL4RfEWI5NeECVEKSeqSkLIS9Sd0tEkdbMWH6DilJ4wrShf0CzqsGKEMC36Evv-E4LpQ9DDqlLd7c6ErPLjYv8ZeF7EtxhUUfgrdKfrcap_g6_t5gh5__3pc3pX3D7d_ljf3peFMjqXJ2rUxYEA2WlaV4BZsLZgxlVkIibFogdWyboSUkjAjJV4IXIGwjaiJoCfox1r2eTI9NBbCOGivngfX6-FVRe3UbiW4leriX0Ulq7iUWWC5FjD5EfsFdis29mq2Ss1WKUJUdjKrXL5fY4gvE6RR9S5Z8F4HiFPKhBoLzCmbG57_B32K0xCyRxnFs82S0i1Upz0oF9qYm9tZVN0sKONcMoEz6moPKq8GemdjgNbl_A7hYouwAu3HVYp-Gl0MaReI10A7xJQGaDeOEKzmadrnwdn2V2wIH-ND_wGz48Hv</recordid><startdate>20131017</startdate><enddate>20131017</enddate><creator>Ki, Eun Young</creator><creator>Hwang, Seon Jeong</creator><creator>Lee, Keun Ho</creator><creator>Park, Jong Sup</creator><creator>Hur, Soo Young</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20131017</creationdate><title>Benign metastasizing leiomyoma of the lung</title><author>Ki, Eun Young ; Hwang, Seon Jeong ; Lee, Keun Ho ; Park, Jong Sup ; Hur, Soo Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b648t-b4139bbebe8da82276cec974bb2b578007fe4989d788814b8805702e7cd79173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Care and treatment</topic><topic>Case Report</topic><topic>Case studies</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Immunohistochemistry</topic><topic>Leiomyoma</topic><topic>Leiomyoma - pathology</topic><topic>Leiomyoma - surgery</topic><topic>Lung diseases</topic><topic>Lung Neoplasms - secondary</topic><topic>Lung Neoplasms - surgery</topic><topic>Middle Aged</topic><topic>Muscle proteins</topic><topic>Patient outcomes</topic><topic>Postmenopausal women</topic><topic>Prognosis</topic><topic>Risk factors</topic><topic>Tomography, X-Ray Computed</topic><topic>Uterine Neoplasms - pathology</topic><topic>Uterine Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ki, Eun Young</creatorcontrib><creatorcontrib>Hwang, Seon Jeong</creatorcontrib><creatorcontrib>Lee, Keun Ho</creatorcontrib><creatorcontrib>Park, Jong Sup</creatorcontrib><creatorcontrib>Hur, Soo Young</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ki, Eun Young</au><au>Hwang, Seon Jeong</au><au>Lee, Keun Ho</au><au>Park, Jong Sup</au><au>Hur, Soo Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Benign metastasizing leiomyoma of the lung</atitle><jtitle>World journal of surgical oncology</jtitle><addtitle>World J Surg Oncol</addtitle><date>2013-10-17</date><risdate>2013</risdate><volume>11</volume><issue>1</issue><spage>279</spage><epage>279</epage><pages>279-279</pages><artnum>279</artnum><issn>1477-7819</issn><eissn>1477-7819</eissn><abstract>Benign leiomyomas of the uterus are uncommonly found in association with benign smooth muscle tumors beyond the confines of the uterus. Benign metastasizing leiomyoma (BML) is a rare disease in which the lung is described to be the most afflicted extrauterine organ. We present a brief review of the literature, along with case reports for four patients who were followed up after resection of a pulmonary lesion or after pathological confirmation by biopsy. The clinical course of BML varies from chronic asymptomatic appearance to rapid progression, leading to respiratory failure and death. Our BML patients did not complain of pulmonary symptoms, such as cough, dyspnea, or chest tightness. Pathology revealed benign leiomyomas with no atypia and mitotic activity <5 per 10 high-power field. Immunohistochemical staining was positive for actin and desmin. A standard treatment for BML has not yet been established. Because of the hormone-sensitive characteristics of BML, treatments are based on hormonal manipulation along with either surgical or medical oophorectomy. Benign metastasizing leiomyoma can be observed in postmenopausal women. We observed four patients who did not receive adjuvant hormonal therapy because they were postmenopausal or perimenopausal. All patients are still healthy and show no evidence of recurrence or progression of the disease.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>24134076</pmid><doi>10.1186/1477-7819-11-279</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Care and treatment Case Report Case studies Development and progression Diagnosis Female Humans Immunoenzyme Techniques Immunohistochemistry Leiomyoma Leiomyoma - pathology Leiomyoma - surgery Lung diseases Lung Neoplasms - secondary Lung Neoplasms - surgery Middle Aged Muscle proteins Patient outcomes Postmenopausal women Prognosis Risk factors Tomography, X-Ray Computed Uterine Neoplasms - pathology Uterine Neoplasms - surgery |
| title | Benign metastasizing leiomyoma of the lung |
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