The diagnostic accuracy of pleural effusion and plasma samples versus tumour tissue for detection of EGFR mutation in patients with advanced non-small cell lung cancer: comparison of methodologies

Aims To evaluate the suitability of malignant pleural effusion (MPE) and plasma as surrogate samples for epidermal growth factor receptor (EGFR) mutation detection, and compare three different detection methods. Methods Matched tissue and plasma samples were collected from patients with advanced non...

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Veröffentlicht in:	Journal of clinical pathology 2013-12, Vol.66 (12), p.1065-1069
Hauptverfasser:	Liu, Xiaoqing, Lu, Yachao, Zhu, Guanshan, Lei, Yao, Zheng, Li, Qin, Haifeng, Tang, Chuanhao, Ellison, Gillian, McCormack, Rose, Ji, Qunsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - genetics Adenocarcinoma - metabolism Adenocarcinoma - pathology Adult Aged Aged, 80 and over Carcinoma, Adenosquamous - genetics Carcinoma, Adenosquamous - metabolism Carcinoma, Adenosquamous - pathology Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology China Deoxyribonucleic acid Diagnostics DNA DNA, Neoplasm - chemistry DNA, Neoplasm - genetics Egfr Female Humans Immunohistochemistry Lung Cancer Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Male Methods Middle Aged Mutation Original Pathology Patients Plasma Pleural Effusion, Malignant - genetics Pleural Effusion, Malignant - metabolism Pleural Effusion, Malignant - pathology Quality Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Sensitivity and Specificity Sequence Analysis, DNA Studies
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