Genetically Modified Neural Stem Cells for a Local and Sustained Delivery of Neuroprotective Factors to the Dystrophic Mouse Retina

In two mouse models of retinitis pigmentosa, intravitreal transplantations of adherently cultivated neural stem cells that had been modified to secrete ciliary neurotrophic factor resulted in a sustained delivery of functionally relevant quantities of the cytokine to the dystrophic retina. These tra...

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Veröffentlicht in:	Stem cells translational medicine 2013-12, Vol.2 (12), p.1001-1010
Hauptverfasser:	Jung, Gila, Sun, Jing, Petrowitz, Bettina, Riecken, Kristoffer, Kruszewski, Katharina, Jankowiak, Wanda, Kunst, Frank, Skevas, Christos, Richard, Gisbert, Fehse, Boris, Bartsch, Udo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Cell culture Cells, Cultured Ciliary neurotrophic factor Ciliary Neurotrophic Factor - genetics Ciliary Neurotrophic Factor - metabolism Clinical trials Cyclic Nucleotide Phosphodiesterases, Type 6 - genetics Cytokines Data analysis Disease Models, Animal Genetic Therapy Genetic Vectors Growth factors Lentiviral vector Lentivirus - genetics Mice Mice, Inbred C57BL Mice, Mutant Strains Mutation Nervous system Neural stem cell Neural stem cells Neural Stem Cells - metabolism Neural Stem Cells - transplantation Neurogenesis Neuroprotection Neurotrophic factors Photoreceptor Cells, Vertebrate - metabolism Photoreceptors Retina Retina - metabolism Retina - pathology Retinal degeneration Retinal photoreceptors Retinitis Retinitis pigmentosa Retinitis Pigmentosa - genetics Retinitis Pigmentosa - metabolism Retinitis Pigmentosa - pathology Retinitis Pigmentosa - therapy Spheroids, Cellular Stem cell transplantation Stem cells Tissue Engineering and Regenerative Medicine Transduction, Genetic Transfection Transplants & implants
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