Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo

Cell migration is essential for development, but its deregulation causes metastasis. The Scar/WAVE complex is absolutely required for lamellipodia and is a key effector in cell migration, but its regulation in vivo is enigmatic. Lamellipodin (Lpd) controls lamellipodium formation through an unknown...

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Veröffentlicht in:	The Journal of cell biology 2013-11, Vol.203 (4), p.673-689
Hauptverfasser:	Law, Ah-Lai, Vehlow, Anne, Kotini, Maria, Dodgson, Lauren, Soong, Daniel, Theveneau, Eric, Bodo, Cristian, Taylor, Eleanor, Navarro, Christel, Perera, Upamali, Michael, Magdalene, Dunn, Graham A, Bennett, Daimark, Mayor, Roberto, Krause, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - chemistry Adaptor Proteins, Signal Transducing - metabolism Animals Binding Sites Cell Movement Cellular biology Cytoskeletal Proteins - chemistry Cytoskeletal Proteins - metabolism Drosophila melanogaster - cytology Drosophila melanogaster - metabolism Drosophila Proteins - metabolism Epithelial Cells - cytology Fibroblasts - cytology Fibroblasts - metabolism Green Fluorescent Proteins - metabolism HEK293 Cells Humans Insects Life Sciences Melanocytes - cytology Melanocytes - metabolism Melanoma, Experimental - metabolism Melanoma, Experimental - pathology Membrane Proteins - metabolism Metastasis Mice Mice, Knockout Neural Crest - cytology Neural Crest - metabolism NIH 3T3 Cells Pigmentation Protein Binding Proteins Pseudopodia - metabolism rac GTP-Binding Proteins - metabolism Rodents src Homology Domains Wiskott-Aldrich Syndrome Protein Family - metabolism Xenopus - metabolism
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