Danggui-Jakyak-San ameliorates memory impairment and increase neurogenesis induced by transient forebrain ischemia in mice
Danggui-Jakyak-San (DJS), a traditional herbal prescription, has been used to treat insufficient blood supplies. Recently, regenerative medication for the treatment of cerebral ischemia has drawn the attention of many researchers. In this study, we examined whether DJS exerts a neuronal regenerative...
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| Veröffentlicht in: | BMC complementary and alternative medicine 2013-11, Vol.13 (1), p.324-324, Article 324 |
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| creator | Song, Mi Deok Kim, Dong Hyun Kim, Jong Min Lee, Hyung Eun Park, Se Jin Ryu, Jong Hoon Lew, Jae Hwan |
| description | Danggui-Jakyak-San (DJS), a traditional herbal prescription, has been used to treat insufficient blood supplies. Recently, regenerative medication for the treatment of cerebral ischemia has drawn the attention of many researchers.
In this study, we examined whether DJS exerts a neuronal regenerative effect in the hippocampus of a transient forebrain ischemia mice model. Transient forebrain ischemia was induced by bilateral common carotid artery occlusion (BCCAO). Animals were divided into three groups (sham, BCCAO + vehicle, and BCCAO + DJS). To test the effect of DJS on learning and memory, Morris water maze or passive avoidance test was conducted. To test neuroprotective and neurogenic effect, immunohistochemistry and Western blot analysis were used. Statistical significance was analyzed with Student t-test, one-way or two-way analysis of variance.
We found that the administration of DJS ameliorated ischemia-induced spatial memory impairment in the Morris water maze task. Moreover, Akt/glycogen synthase kinase-3β (GSK3β)/β-catenin signaling was increased by DJS, which would be one possible mechanism of DJS for neurogenesis in the hippocampal dentate gyrus region.
These results suggest that DJS is a possible candidate for the treatment of ischemia-induced neuronal degeneration. |
| doi_str_mv | 10.1186/1472-6882-13-324 |
| format | Article |
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In this study, we examined whether DJS exerts a neuronal regenerative effect in the hippocampus of a transient forebrain ischemia mice model. Transient forebrain ischemia was induced by bilateral common carotid artery occlusion (BCCAO). Animals were divided into three groups (sham, BCCAO + vehicle, and BCCAO + DJS). To test the effect of DJS on learning and memory, Morris water maze or passive avoidance test was conducted. To test neuroprotective and neurogenic effect, immunohistochemistry and Western blot analysis were used. Statistical significance was analyzed with Student t-test, one-way or two-way analysis of variance.
We found that the administration of DJS ameliorated ischemia-induced spatial memory impairment in the Morris water maze task. Moreover, Akt/glycogen synthase kinase-3β (GSK3β)/β-catenin signaling was increased by DJS, which would be one possible mechanism of DJS for neurogenesis in the hippocampal dentate gyrus region.
These results suggest that DJS is a possible candidate for the treatment of ischemia-induced neuronal degeneration.</description><identifier>ISSN: 1472-6882</identifier><identifier>EISSN: 1472-6882</identifier><identifier>DOI: 10.1186/1472-6882-13-324</identifier><identifier>PMID: 24261472</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>AKT protein ; Analysis ; Animals ; Aqueous solutions ; Behavior ; Brain ; Brain Ischemia - complications ; Care and treatment ; Carotid arteries ; Colleges & universities ; Drug dosages ; Experiments ; Hippocampus - cytology ; Hippocampus - drug effects ; Humans ; Immunoglobulins ; Ischemia ; Ischemic Attack, Transient - complications ; Kinases ; Laboratories ; Male ; Medicinal plants ; Memory ; Memory Disorders - drug therapy ; Memory Disorders - etiology ; Memory Disorders - physiopathology ; Memory, Disorders of ; Mice ; Mice, Inbred C57BL ; Nervous system ; Neurogenesis ; Neurogenesis - drug effects ; Neurons ; Pharmaceutical sciences ; Physiological aspects ; Plant Extracts - administration & dosage ; Retention ; Variance analysis ; Veins & arteries</subject><ispartof>BMC complementary and alternative medicine, 2013-11, Vol.13 (1), p.324-324, Article 324</ispartof><rights>COPYRIGHT 2013 BioMed Central Ltd.</rights><rights>2013 Song et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Song et al.; licensee BioMed Central Ltd. 2013 Song et al.; licensee BioMed Central Ltd.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c555t-16badef45038c0f46df61067633c4085dc5453afa77a373b505d90a871fbfabc3</citedby><cites>FETCH-LOGICAL-c555t-16badef45038c0f46df61067633c4085dc5453afa77a373b505d90a871fbfabc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840576/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840576/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24261472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Mi Deok</creatorcontrib><creatorcontrib>Kim, Dong Hyun</creatorcontrib><creatorcontrib>Kim, Jong Min</creatorcontrib><creatorcontrib>Lee, Hyung Eun</creatorcontrib><creatorcontrib>Park, Se Jin</creatorcontrib><creatorcontrib>Ryu, Jong Hoon</creatorcontrib><creatorcontrib>Lew, Jae Hwan</creatorcontrib><title>Danggui-Jakyak-San ameliorates memory impairment and increase neurogenesis induced by transient forebrain ischemia in mice</title><title>BMC complementary and alternative medicine</title><addtitle>BMC Complement Altern Med</addtitle><description>Danggui-Jakyak-San (DJS), a traditional herbal prescription, has been used to treat insufficient blood supplies. Recently, regenerative medication for the treatment of cerebral ischemia has drawn the attention of many researchers.
In this study, we examined whether DJS exerts a neuronal regenerative effect in the hippocampus of a transient forebrain ischemia mice model. Transient forebrain ischemia was induced by bilateral common carotid artery occlusion (BCCAO). Animals were divided into three groups (sham, BCCAO + vehicle, and BCCAO + DJS). To test the effect of DJS on learning and memory, Morris water maze or passive avoidance test was conducted. To test neuroprotective and neurogenic effect, immunohistochemistry and Western blot analysis were used. Statistical significance was analyzed with Student t-test, one-way or two-way analysis of variance.
We found that the administration of DJS ameliorated ischemia-induced spatial memory impairment in the Morris water maze task. Moreover, Akt/glycogen synthase kinase-3β (GSK3β)/β-catenin signaling was increased by DJS, which would be one possible mechanism of DJS for neurogenesis in the hippocampal dentate gyrus region.
These results suggest that DJS is a possible candidate for the treatment of ischemia-induced neuronal degeneration.</description><subject>AKT protein</subject><subject>Analysis</subject><subject>Animals</subject><subject>Aqueous solutions</subject><subject>Behavior</subject><subject>Brain</subject><subject>Brain Ischemia - complications</subject><subject>Care and treatment</subject><subject>Carotid arteries</subject><subject>Colleges & universities</subject><subject>Drug dosages</subject><subject>Experiments</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Ischemia</subject><subject>Ischemic Attack, Transient - complications</subject><subject>Kinases</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medicinal plants</subject><subject>Memory</subject><subject>Memory Disorders - drug therapy</subject><subject>Memory Disorders - etiology</subject><subject>Memory Disorders - physiopathology</subject><subject>Memory, Disorders of</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Nervous system</subject><subject>Neurogenesis</subject><subject>Neurogenesis - drug effects</subject><subject>Neurons</subject><subject>Pharmaceutical sciences</subject><subject>Physiological aspects</subject><subject>Plant Extracts - administration & dosage</subject><subject>Retention</subject><subject>Variance analysis</subject><subject>Veins & arteries</subject><issn>1472-6882</issn><issn>1472-6882</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkk1v1DAQhiMEomXhzglZQqq4pNjxR7IXpKqUL1XiAJytiTPOuk3sxU6Qtr8eRy3LLkI-2Jp53hnP6C2Kl4yeM9aot0zUVamapioZL3klHhWn-9Djg_dJ8SylG0pZ3TDxtDipRKWW5Glx9x5838-u_AK3O7gtv4EnMOLgQoQJExlxDHFH3LgFF0f0EwHfEedNREhIPM4x9OgxuZSj3WywI-2OTBF8cgtuQ8Q2gvPEJbPB0UHmyOgMPi-eWBgSvni4V8WPD1ffLz-V118_fr68uC6NlHIqmWqhQysk5Y2hVqjOKkZVrTg3gjayM1JIDhbqGnjNW0llt6bQ1My2FlrDV8W7-7rbuR2xM_lXEQa9jW6EuNMBnD7OeLfRffileSOozH1WxZuHAjH8nDFNesyz4DCAxzAnzcS6UtVarmlGX_-D3oQ5-jxephSra6Yo-0v1MKB23obc1yxF9YXkQnHJK5mp8_9Q-XR5iyZ4tC7HjwRnB4INwjBtUhjmyQWfjkF6D5oYUopo98tgVC_G0os59OIczbjOxsqSV4dL3Av-OIn_BvhvyPA</recordid><startdate>20131122</startdate><enddate>20131122</enddate><creator>Song, Mi Deok</creator><creator>Kim, Dong Hyun</creator><creator>Kim, Jong Min</creator><creator>Lee, Hyung Eun</creator><creator>Park, Se Jin</creator><creator>Ryu, Jong Hoon</creator><creator>Lew, Jae Hwan</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20131122</creationdate><title>Danggui-Jakyak-San ameliorates memory impairment and increase neurogenesis induced by transient forebrain ischemia in mice</title><author>Song, Mi Deok ; Kim, Dong Hyun ; Kim, Jong Min ; Lee, Hyung Eun ; Park, Se Jin ; Ryu, Jong Hoon ; Lew, Jae Hwan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c555t-16badef45038c0f46df61067633c4085dc5453afa77a373b505d90a871fbfabc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>AKT protein</topic><topic>Analysis</topic><topic>Animals</topic><topic>Aqueous solutions</topic><topic>Behavior</topic><topic>Brain</topic><topic>Brain Ischemia - complications</topic><topic>Care and treatment</topic><topic>Carotid arteries</topic><topic>Colleges & universities</topic><topic>Drug dosages</topic><topic>Experiments</topic><topic>Hippocampus - cytology</topic><topic>Hippocampus - drug effects</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Ischemia</topic><topic>Ischemic Attack, Transient - complications</topic><topic>Kinases</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medicinal plants</topic><topic>Memory</topic><topic>Memory Disorders - drug therapy</topic><topic>Memory Disorders - etiology</topic><topic>Memory Disorders - physiopathology</topic><topic>Memory, Disorders of</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Nervous system</topic><topic>Neurogenesis</topic><topic>Neurogenesis - drug effects</topic><topic>Neurons</topic><topic>Pharmaceutical sciences</topic><topic>Physiological aspects</topic><topic>Plant Extracts - administration & dosage</topic><topic>Retention</topic><topic>Variance analysis</topic><topic>Veins & arteries</topic><toplevel>online_resources</toplevel><creatorcontrib>Song, Mi Deok</creatorcontrib><creatorcontrib>Kim, Dong Hyun</creatorcontrib><creatorcontrib>Kim, Jong Min</creatorcontrib><creatorcontrib>Lee, Hyung Eun</creatorcontrib><creatorcontrib>Park, Se Jin</creatorcontrib><creatorcontrib>Ryu, Jong Hoon</creatorcontrib><creatorcontrib>Lew, Jae Hwan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Song, Mi Deok</au><au>Kim, Dong Hyun</au><au>Kim, Jong Min</au><au>Lee, Hyung Eun</au><au>Park, Se Jin</au><au>Ryu, Jong Hoon</au><au>Lew, Jae Hwan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Danggui-Jakyak-San ameliorates memory impairment and increase neurogenesis induced by transient forebrain ischemia in mice</atitle><jtitle>BMC complementary and alternative medicine</jtitle><addtitle>BMC Complement Altern Med</addtitle><date>2013-11-22</date><risdate>2013</risdate><volume>13</volume><issue>1</issue><spage>324</spage><epage>324</epage><pages>324-324</pages><artnum>324</artnum><issn>1472-6882</issn><eissn>1472-6882</eissn><abstract>Danggui-Jakyak-San (DJS), a traditional herbal prescription, has been used to treat insufficient blood supplies. Recently, regenerative medication for the treatment of cerebral ischemia has drawn the attention of many researchers.
In this study, we examined whether DJS exerts a neuronal regenerative effect in the hippocampus of a transient forebrain ischemia mice model. Transient forebrain ischemia was induced by bilateral common carotid artery occlusion (BCCAO). Animals were divided into three groups (sham, BCCAO + vehicle, and BCCAO + DJS). To test the effect of DJS on learning and memory, Morris water maze or passive avoidance test was conducted. To test neuroprotective and neurogenic effect, immunohistochemistry and Western blot analysis were used. Statistical significance was analyzed with Student t-test, one-way or two-way analysis of variance.
We found that the administration of DJS ameliorated ischemia-induced spatial memory impairment in the Morris water maze task. Moreover, Akt/glycogen synthase kinase-3β (GSK3β)/β-catenin signaling was increased by DJS, which would be one possible mechanism of DJS for neurogenesis in the hippocampal dentate gyrus region.
These results suggest that DJS is a possible candidate for the treatment of ischemia-induced neuronal degeneration.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>24261472</pmid><doi>10.1186/1472-6882-13-324</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | AKT protein Analysis Animals Aqueous solutions Behavior Brain Brain Ischemia - complications Care and treatment Carotid arteries Colleges & universities Drug dosages Experiments Hippocampus - cytology Hippocampus - drug effects Humans Immunoglobulins Ischemia Ischemic Attack, Transient - complications Kinases Laboratories Male Medicinal plants Memory Memory Disorders - drug therapy Memory Disorders - etiology Memory Disorders - physiopathology Memory, Disorders of Mice Mice, Inbred C57BL Nervous system Neurogenesis Neurogenesis - drug effects Neurons Pharmaceutical sciences Physiological aspects Plant Extracts - administration & dosage Retention Variance analysis Veins & arteries |
| title | Danggui-Jakyak-San ameliorates memory impairment and increase neurogenesis induced by transient forebrain ischemia in mice |
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