Small-molecule antagonists of melanopsin-mediated phototransduction

Opsinamides are nonretinoid inhibitors that compete with 9- cis -retinal for binding to melanopsin Opn4 without affecting rod- and cone-mediated visual responses but affecting tolerance to light and light exacerbation of migraine. Melanopsin, expressed in a subset of retinal ganglion cells, mediates...

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Veröffentlicht in:	Nature chemical biology 2013-10, Vol.9 (10), p.630-635
Hauptverfasser:	Jones, Kenneth A, Hatori, Megumi, Mure, Ludovic S, Bramley, Jayne R, Artymyshyn, Roman, Hong, Sang-Phyo, Marzabadi, Mohammad, Zhong, Huailing, Sprouse, Jeffrey, Zhu, Quansheng, Hartwick, Andrew T E, Sollars, Patricia J, Pickard, Gary E, Panda, Satchidananda
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154 631/378/340 631/92/604 Biochemical Engineering Biochemistry Bioorganic Chemistry Cell Biology Central nervous system Chemistry Chemistry/Food Science Circadian rhythms Humans Light Signal Transduction - drug effects Molecular biology Molecular chemistry Molecular Structure Pharmacology Rod Opsins - antagonists & inhibitors Rod Opsins - metabolism Sleep Small Molecule Libraries - chemical synthesis Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Structure-Activity Relationship Sulfonamides - chemical synthesis Sulfonamides - chemistry Sulfonamides - pharmacology Synthetic biology
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