Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations
Yukinori Okada and colleagues report a genome-wide association study for body mass index (BMI) in east Asians. They identify genetic variants associated with BMI near CDKAL1 and KLF9 . Obesity is a disorder with a complex genetic etiology, and its epidemic is a worldwide problem. Although multiple g...
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| Veröffentlicht in: | Nature genetics 2012-03, Vol.44 (3), p.302-306 |
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| creator | Okada, Yukinori Kubo, Michiaki Ohmiya, Hiroko Takahashi, Atsushi Kumasaka, Natsuhiko Hosono, Naoya Maeda, Shiro Wen, Wanqing Dorajoo, Rajkumar Go, Min Jin Zheng, Wei Kato, Norihiro Wu, Jer-Yuarn Lu, Qi Tsunoda, Tatsuhiko Yamamoto, Kazuhiko Nakamura, Yusuke Kamatani, Naoyuki Tanaka, Toshihiro |
| description | Yukinori Okada and colleagues report a genome-wide association study for body mass index (BMI) in east Asians. They identify genetic variants associated with BMI near
CDKAL1
and
KLF9
.
Obesity is a disorder with a complex genetic etiology, and its epidemic is a worldwide problem. Although multiple genetic loci associated with body mass index, the most common measure of obesity, have been identified in European populations, few studies have focused on Asian populations. Here we report a genome-wide association study and replication studies with 62,245 east Asian subjects, which identified two new body mass index–associated loci in the
CDKAL1
locus at 6p22 (rs2206734,
P
= 1.4 × 10
−11
) and the
KLF9
locus at 9q21 (rs11142387,
P
= 1.3 × 10
−9
), as well as several previously reported loci (the
SEC16B
,
BDNF, FTO
,
MC4R
and
GIPR
loci,
P
< 5.0 × 10
−8
). We subsequently performed gene-gene interaction analyses and identified an interaction (
P
= 2.0 × 10
−8
) between a SNP in the
KLF9
locus (rs11142387) and one in the
MSTN
(also known as
GDF8
) locus at 2q32 (rs13034723). These findings should provide useful insights into the etiology of obesity. |
| doi_str_mv | 10.1038/ng.1086 |
| format | Article |
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CDKAL1
and
KLF9
.
Obesity is a disorder with a complex genetic etiology, and its epidemic is a worldwide problem. Although multiple genetic loci associated with body mass index, the most common measure of obesity, have been identified in European populations, few studies have focused on Asian populations. Here we report a genome-wide association study and replication studies with 62,245 east Asian subjects, which identified two new body mass index–associated loci in the
CDKAL1
locus at 6p22 (rs2206734,
P
= 1.4 × 10
−11
) and the
KLF9
locus at 9q21 (rs11142387,
P
= 1.3 × 10
−9
), as well as several previously reported loci (the
SEC16B
,
BDNF, FTO
,
MC4R
and
GIPR
loci,
P
< 5.0 × 10
−8
). We subsequently performed gene-gene interaction analyses and identified an interaction (
P
= 2.0 × 10
−8
) between a SNP in the
KLF9
locus (rs11142387) and one in the
MSTN
(also known as
GDF8
) locus at 2q32 (rs13034723). These findings should provide useful insights into the etiology of obesity.</description><identifier>ISSN: 1061-4036</identifier><identifier>EISSN: 1546-1718</identifier><identifier>DOI: 10.1038/ng.1086</identifier><identifier>PMID: 22344221</identifier><identifier>CODEN: NGENEC</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/208/205/2138 ; 631/208/2489/144 ; 692/699/2743/393 ; Agriculture ; Animal Genetics and Genomics ; Asian Americans ; Asian Continental Ancestry Group - genetics ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Body Mass Index ; Cancer Research ; Chromosomes, Human, Pair 6 - genetics ; Chromosomes, Human, Pair 9 - genetics ; Cyclin-Dependent Kinase 5 - genetics ; Cyclin-dependent kinases ; Etiology ; Far East ; Fundamental and applied biological sciences. Psychology ; Gene Function ; Genetic aspects ; Genetic Variation ; Genetics ; Genetics of eukaryotes. Biological and molecular evolution ; Genome-Wide Association Study ; Genomes ; Genotype ; Human Genetics ; Humans ; Kruppel-Like Transcription Factors - genetics ; letter ; Meta-analysis ; Obesity ; Obesity - ethnology ; Obesity - genetics ; Polymorphism, Single Nucleotide - genetics ; Principal components analysis ; Risk factors ; Single nucleotide polymorphisms ; Studies ; tRNA Methyltransferases</subject><ispartof>Nature genetics, 2012-03, Vol.44 (3), p.302-306</ispartof><rights>Springer Nature America, Inc. 2012</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2012 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c664t-f30041647f67726ca576b861abebaff3c2a7fe57219d9548866f31556952eb323</citedby><cites>FETCH-LOGICAL-c664t-f30041647f67726ca576b861abebaff3c2a7fe57219d9548866f31556952eb323</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ng.1086$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/ng.1086$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,776,780,881,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25662274$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22344221$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okada, Yukinori</creatorcontrib><creatorcontrib>Kubo, Michiaki</creatorcontrib><creatorcontrib>Ohmiya, Hiroko</creatorcontrib><creatorcontrib>Takahashi, Atsushi</creatorcontrib><creatorcontrib>Kumasaka, Natsuhiko</creatorcontrib><creatorcontrib>Hosono, Naoya</creatorcontrib><creatorcontrib>Maeda, Shiro</creatorcontrib><creatorcontrib>Wen, Wanqing</creatorcontrib><creatorcontrib>Dorajoo, Rajkumar</creatorcontrib><creatorcontrib>Go, Min Jin</creatorcontrib><creatorcontrib>Zheng, Wei</creatorcontrib><creatorcontrib>Kato, Norihiro</creatorcontrib><creatorcontrib>Wu, Jer-Yuarn</creatorcontrib><creatorcontrib>Lu, Qi</creatorcontrib><creatorcontrib>Tsunoda, Tatsuhiko</creatorcontrib><creatorcontrib>Yamamoto, Kazuhiko</creatorcontrib><creatorcontrib>Nakamura, Yusuke</creatorcontrib><creatorcontrib>Kamatani, Naoyuki</creatorcontrib><creatorcontrib>Tanaka, Toshihiro</creatorcontrib><creatorcontrib>GIANT consortium</creatorcontrib><title>Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations</title><title>Nature genetics</title><addtitle>Nat Genet</addtitle><addtitle>Nat Genet</addtitle><description>Yukinori Okada and colleagues report a genome-wide association study for body mass index (BMI) in east Asians. They identify genetic variants associated with BMI near
CDKAL1
and
KLF9
.
Obesity is a disorder with a complex genetic etiology, and its epidemic is a worldwide problem. Although multiple genetic loci associated with body mass index, the most common measure of obesity, have been identified in European populations, few studies have focused on Asian populations. Here we report a genome-wide association study and replication studies with 62,245 east Asian subjects, which identified two new body mass index–associated loci in the
CDKAL1
locus at 6p22 (rs2206734,
P
= 1.4 × 10
−11
) and the
KLF9
locus at 9q21 (rs11142387,
P
= 1.3 × 10
−9
), as well as several previously reported loci (the
SEC16B
,
BDNF, FTO
,
MC4R
and
GIPR
loci,
P
< 5.0 × 10
−8
). We subsequently performed gene-gene interaction analyses and identified an interaction (
P
= 2.0 × 10
−8
) between a SNP in the
KLF9
locus (rs11142387) and one in the
MSTN
(also known as
GDF8
) locus at 2q32 (rs13034723). These findings should provide useful insights into the etiology of obesity.</description><subject>631/208/205/2138</subject><subject>631/208/2489/144</subject><subject>692/699/2743/393</subject><subject>Agriculture</subject><subject>Animal Genetics and Genomics</subject><subject>Asian Americans</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Biological and medical sciences</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body Mass Index</subject><subject>Cancer Research</subject><subject>Chromosomes, Human, Pair 6 - genetics</subject><subject>Chromosomes, Human, Pair 9 - genetics</subject><subject>Cyclin-Dependent Kinase 5 - genetics</subject><subject>Cyclin-dependent kinases</subject><subject>Etiology</subject><subject>Far East</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Function</subject><subject>Genetic aspects</subject><subject>Genetic Variation</subject><subject>Genetics</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Genome-Wide Association Study</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Kruppel-Like Transcription Factors - genetics</subject><subject>letter</subject><subject>Meta-analysis</subject><subject>Obesity</subject><subject>Obesity - ethnology</subject><subject>Obesity - genetics</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Principal components analysis</subject><subject>Risk factors</subject><subject>Single nucleotide polymorphisms</subject><subject>Studies</subject><subject>tRNA Methyltransferases</subject><issn>1061-4036</issn><issn>1546-1718</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkmtvFCEUhidGYy8a_4EhGqN-2AoMMMwXk81qtekmTbx9xTMMTGlmYB2YXv69rF1btzHGkHAI5zkv8B6K4gnBBwSX8o3vcpTiXrFLOBMzUhF5P6-xIDOGS7FT7MV4hjFhDMuHxQ6lJWOUkt3i-yIMQ_DoHEYHPkUECS3eHc-XBIFv0fHysEYwGgQxBu0gmRZduHSKmtBeoSHvIudbc5lnZCAmNI9ZBq3CauohueDjo-KBhT6ax5u4X3w9fP9l8XG2PPlwtJgvZ1oIlma2xJgRwSorqooKDbwSjRQEGtOAtaWmUFnDK0rqtuZMSiFsSTgXNaemKWm5X7y91l1NzWBabXwaoVer0Q0wXqkATm1nvDtVXThXpSylrFgWeLkRGMOPycSkBhe16XvwJkxR1bSsOcd4fdSrf5K5I0wSWROR0Wd30LMwjT4boWpBGZUc8ww9v4Y66I1y3oZ8Qb3WVHMqKZcUVzJTB3-h8mjN4HTwxrq8v1XweqsgM8lcpg6mGNXR50__z55822Y3RukxxDgae2Myweu3S-U7tf6NmXz6Z09uuN_fLwMvNgBEDb0dwWsXbzkuBKW_erNxPOaU78x4a-PdM38C8Gzu6Q</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Okada, Yukinori</creator><creator>Kubo, Michiaki</creator><creator>Ohmiya, Hiroko</creator><creator>Takahashi, Atsushi</creator><creator>Kumasaka, Natsuhiko</creator><creator>Hosono, Naoya</creator><creator>Maeda, Shiro</creator><creator>Wen, Wanqing</creator><creator>Dorajoo, Rajkumar</creator><creator>Go, Min Jin</creator><creator>Zheng, Wei</creator><creator>Kato, Norihiro</creator><creator>Wu, Jer-Yuarn</creator><creator>Lu, Qi</creator><creator>Tsunoda, Tatsuhiko</creator><creator>Yamamoto, Kazuhiko</creator><creator>Nakamura, Yusuke</creator><creator>Kamatani, Naoyuki</creator><creator>Tanaka, Toshihiro</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120301</creationdate><title>Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations</title><author>Okada, Yukinori ; Kubo, Michiaki ; Ohmiya, Hiroko ; Takahashi, Atsushi ; Kumasaka, Natsuhiko ; Hosono, Naoya ; Maeda, Shiro ; Wen, Wanqing ; Dorajoo, Rajkumar ; Go, Min Jin ; Zheng, Wei ; Kato, Norihiro ; Wu, Jer-Yuarn ; Lu, Qi ; Tsunoda, Tatsuhiko ; Yamamoto, Kazuhiko ; Nakamura, Yusuke ; Kamatani, Naoyuki ; Tanaka, Toshihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c664t-f30041647f67726ca576b861abebaff3c2a7fe57219d9548866f31556952eb323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>631/208/205/2138</topic><topic>631/208/2489/144</topic><topic>692/699/2743/393</topic><topic>Agriculture</topic><topic>Animal Genetics and Genomics</topic><topic>Asian Americans</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Biological and medical sciences</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body Mass Index</topic><topic>Cancer Research</topic><topic>Chromosomes, Human, Pair 6 - genetics</topic><topic>Chromosomes, Human, Pair 9 - genetics</topic><topic>Cyclin-Dependent Kinase 5 - genetics</topic><topic>Cyclin-dependent kinases</topic><topic>Etiology</topic><topic>Far East</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Function</topic><topic>Genetic aspects</topic><topic>Genetic Variation</topic><topic>Genetics</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Genome-Wide Association Study</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Kruppel-Like Transcription Factors - genetics</topic><topic>letter</topic><topic>Meta-analysis</topic><topic>Obesity</topic><topic>Obesity - ethnology</topic><topic>Obesity - genetics</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Principal components analysis</topic><topic>Risk factors</topic><topic>Single nucleotide polymorphisms</topic><topic>Studies</topic><topic>tRNA Methyltransferases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okada, Yukinori</creatorcontrib><creatorcontrib>Kubo, Michiaki</creatorcontrib><creatorcontrib>Ohmiya, Hiroko</creatorcontrib><creatorcontrib>Takahashi, Atsushi</creatorcontrib><creatorcontrib>Kumasaka, Natsuhiko</creatorcontrib><creatorcontrib>Hosono, Naoya</creatorcontrib><creatorcontrib>Maeda, 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Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nature genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okada, Yukinori</au><au>Kubo, Michiaki</au><au>Ohmiya, Hiroko</au><au>Takahashi, Atsushi</au><au>Kumasaka, Natsuhiko</au><au>Hosono, Naoya</au><au>Maeda, Shiro</au><au>Wen, Wanqing</au><au>Dorajoo, Rajkumar</au><au>Go, Min Jin</au><au>Zheng, Wei</au><au>Kato, Norihiro</au><au>Wu, Jer-Yuarn</au><au>Lu, Qi</au><au>Tsunoda, Tatsuhiko</au><au>Yamamoto, Kazuhiko</au><au>Nakamura, Yusuke</au><au>Kamatani, Naoyuki</au><au>Tanaka, Toshihiro</au><aucorp>GIANT consortium</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations</atitle><jtitle>Nature genetics</jtitle><stitle>Nat Genet</stitle><addtitle>Nat Genet</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>44</volume><issue>3</issue><spage>302</spage><epage>306</epage><pages>302-306</pages><issn>1061-4036</issn><eissn>1546-1718</eissn><coden>NGENEC</coden><abstract>Yukinori Okada and colleagues report a genome-wide association study for body mass index (BMI) in east Asians. They identify genetic variants associated with BMI near
CDKAL1
and
KLF9
.
Obesity is a disorder with a complex genetic etiology, and its epidemic is a worldwide problem. Although multiple genetic loci associated with body mass index, the most common measure of obesity, have been identified in European populations, few studies have focused on Asian populations. Here we report a genome-wide association study and replication studies with 62,245 east Asian subjects, which identified two new body mass index–associated loci in the
CDKAL1
locus at 6p22 (rs2206734,
P
= 1.4 × 10
−11
) and the
KLF9
locus at 9q21 (rs11142387,
P
= 1.3 × 10
−9
), as well as several previously reported loci (the
SEC16B
,
BDNF, FTO
,
MC4R
and
GIPR
loci,
P
< 5.0 × 10
−8
). We subsequently performed gene-gene interaction analyses and identified an interaction (
P
= 2.0 × 10
−8
) between a SNP in the
KLF9
locus (rs11142387) and one in the
MSTN
(also known as
GDF8
) locus at 2q32 (rs13034723). These findings should provide useful insights into the etiology of obesity.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>22344221</pmid><doi>10.1038/ng.1086</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1061-4036 |
| ispartof | Nature genetics, 2012-03, Vol.44 (3), p.302-306 |
| issn | 1061-4036 1546-1718 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3838874 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; Nature |
| subjects | 631/208/205/2138 631/208/2489/144 692/699/2743/393 Agriculture Animal Genetics and Genomics Asian Americans Asian Continental Ancestry Group - genetics Biological and medical sciences Biomedical and Life Sciences Biomedicine Body Mass Index Cancer Research Chromosomes, Human, Pair 6 - genetics Chromosomes, Human, Pair 9 - genetics Cyclin-Dependent Kinase 5 - genetics Cyclin-dependent kinases Etiology Far East Fundamental and applied biological sciences. Psychology Gene Function Genetic aspects Genetic Variation Genetics Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Genomes Genotype Human Genetics Humans Kruppel-Like Transcription Factors - genetics letter Meta-analysis Obesity Obesity - ethnology Obesity - genetics Polymorphism, Single Nucleotide - genetics Principal components analysis Risk factors Single nucleotide polymorphisms Studies tRNA Methyltransferases |
| title | Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T20%3A34%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Common%20variants%20at%20CDKAL1%20and%20KLF9%20are%20associated%20with%20body%20mass%20index%20in%20east%20Asian%20populations&rft.jtitle=Nature%20genetics&rft.au=Okada,%20Yukinori&rft.aucorp=GIANT%20consortium&rft.date=2012-03-01&rft.volume=44&rft.issue=3&rft.spage=302&rft.epage=306&rft.pages=302-306&rft.issn=1061-4036&rft.eissn=1546-1718&rft.coden=NGENEC&rft_id=info:doi/10.1038/ng.1086&rft_dat=%3Cgale_pubme%3EA282582078%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=962428505&rft_id=info:pmid/22344221&rft_galeid=A282582078&rfr_iscdi=true |