Hira-Dependent Histone H3.3 Deposition Facilitates PRC2 Recruitment at Developmental Loci in ES Cells

Polycomb repressive complex 2 (PRC2) regulates gene expression during lineage specification through trimethylation of lysine 27 on histone H3 (H3K27me3). In Drosophila, polycomb binding sites are dynamic chromatin regions enriched with the histone variant H3.3. Here, we show that, in mouse embryonic...

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Veröffentlicht in:	Cell 2013-09, Vol.155 (1), p.107-120
Hauptverfasser:	Banaszynski, Laura A., Wen, Duancheng, Dewell, Scott, Whitcomb, Sarah J., Lin, Mingyan, Diaz, Nichole, Elsässer, Simon J., Chapgier, Ariane, Goldberg, Aaron D., Canaani, Eli, Rafii, Shahin, Zheng, Deyou, Allis, C. David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals binding sites Cell Cycle Proteins - metabolism Cell Differentiation chromatin Chromatin - metabolism Drosophila Drosophila melanogaster - embryology Drosophila melanogaster - metabolism embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism gene expression genes Histone Chaperones - metabolism histones loci lysine Mice Mice, Inbred C57BL nucleosomes Polycomb Repressive Complex 2 - metabolism Promoter Regions, Genetic RNA Polymerase II - metabolism Transcription Factors - metabolism Up-Regulation
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