Monopolar Spindle 1 (MPS1) Protein-dependent Phosphorylation of RecQ-mediated Genome Instability Protein 2 (RMI2) at Serine 112 Is Essential for BLM-Topo III α-RMI1-RMI2 (BTR) Protein Complex Function upon Spindle Assembly Checkpoint (SAC) Activation during Mitosis

Genomic instability and a predisposition to cancer are hallmarks of Bloom syndrome, an autosomal recessive disease arising from mutations in the BLM gene. BLM is a RecQ helicase component of the BLM-Topo III α-RMI1-RMI2 (BTR) complex, which maintains chromosome stability at the spindle assembly chec...

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Veröffentlicht in:	The Journal of biological chemistry 2013-11, Vol.288 (47), p.33500-33508
Hauptverfasser:	Pradhan, Arun, Singh, Thiyam Ramsing, Ali, Abdullah Mahmood, Wahengbam, Kebola, Meetei, Amom Ruhikanta
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Bloom Syndrome BTR Complex Carrier Proteins - genetics Carrier Proteins - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chromosomal Instability - physiology DNA and Chromosomes DNA Helicase DNA Topoisomerases, Type I - genetics DNA Topoisomerases, Type I - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Genome Instability HEK293 Cells HeLa Cells Humans M Phase Cell Cycle Checkpoints - physiology Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Mutation, Missense Nuclear Proteins - genetics Nuclear Proteins - metabolism Phosphorylation - physiology Posttranslational Modification Protein Phosphorylation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism RecQ Helicases - genetics RecQ Helicases - metabolism RMI2 Serine - genetics Serine - metabolism shRNA Spindle Apparatus - genetics Spindle Apparatus - metabolism Spindle Assembly Checkpoint (SAC) Subcellular Fractionation
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