Conditional Hypovascularization and Hypoxia in Islets Do Not Overtly Influence Adult β-Cell Mass or Function

It is generally accepted that vascularization and oxygenation of pancreatic islets are essential for the maintenance of an optimal β-cell mass and function and that signaling by vascular endothelial growth factor (VEGF) is crucial for pancreas development, insulin gene expression/secretion, and (com...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2013-12, Vol.62 (12), p.4165-4173
Hauptverfasser:	D'HOKER, Joke, DE LEU, Nico, SWISA, Avital, MARTENS, Geert, PIPELEERS, Daniel, VAN DE CASTEELE, Mark, SEINO, Susumo, KESHET, Eli, DOR, Yuval, HEIMBERG, Harry, HEREMANS, Yves, BAEYENS, Luc, MINAMI, Kohtaro, CAI YING, LAVENS, Astrid, CHINTINNE, Marie, STANGE, Geert, MAGENHEIM, Judith
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Genetic aspects Hypoxia - metabolism Hypoxia - physiopathology Insulin Insulin - metabolism Insulin-Secreting Cells - physiology Ischemia - metabolism Ischemia - physiopathology Islands of Langerhans Islets of Langerhans - blood supply Islets of Langerhans - metabolism Islets of Langerhans - physiopathology Medical sciences Mice Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - physiopathology Original Research Pancreatic beta cells Physiological aspects Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-1 - metabolism
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