A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk

Mean telomere length (TL) in blood cells is heritable and has been reported to be associated with risks of several diseases, including cancer. We conducted a meta-analysis of three GWAS for TL (total n=2240) and selected 1629 variants for replication via the "iCOGS" custom genotyping array...

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Veröffentlicht in:	Human molecular genetics 2013-12, Vol.22 (24), p.5056-5064
Hauptverfasser:	Pooley, Karen A, Bojesen, Stig E, Weischer, Maren, Nielsen, Sune F, Thompson, Deborah, Amin Al Olama, Ali, Michailidou, Kyriaki, Tyrer, Jonathan P, Benlloch, Sara, Brown, Judith, Audley, Tina, Luben, Robert, Khaw, K-T, Neal, David E, Hamdy, Freddie C, Donovan, Jenny L, Kote-Jarai, Zsofia, Baynes, Caroline, Shah, Mitul, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Dicks, Ed, Yang, Rongxi, Rudolph, Anja, Schildkraut, Joellen, Chang-Claude, Jenny, Burwinkel, Barbara, Chenevix-Trench, Georgia, Pharoah, Paul D P, Berchuck, Andrew, Eeles, Rosalind A, Easton, Douglas F, Dunning, Alison M, Nordestgaard, Børge G
Format:	Artikel
Sprache:	eng
Schlagworte:	Association Studies Case-Control Studies Chromosome Mapping Female Genetic Loci Genetic Predisposition to Disease Genome-Wide Association Study Humans Male Neoplasms - genetics Neoplasms - metabolism Polymorphism, Single Nucleotide Risk Telomere - genetics Telomere - metabolism Telomere Homeostasis - genetics
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