The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability

SNM1B/Apollo is a DNA nuclease that has important functions in telomere maintenance and repair of DNA interstrand crosslinks (ICLs) within the Fanconi anemia (FA) pathway. SNM1B is required for efficient localization of key repair proteins, such as the FA protein, FANCD2, to sites of ICL damage and...

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Veröffentlicht in:	Human molecular genetics 2013-12, Vol.22 (24), p.4901-4913
Hauptverfasser:	Mason, Jennifer M, Das, Ishita, Arlt, Martin, Patel, Neil, Kraftson, Stephanie, Glover, Thomas W, Sekiguchi, JoAnn M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Motifs Amino Acid Sequence Aphidicolin - pharmacology BRCA1 Protein - metabolism Cell Line Cell Nucleus - metabolism Cell Survival - drug effects Cell Survival - genetics Chromatin - metabolism Chromosome Fragile Sites DNA Damage DNA Repair DNA Repair Enzymes - chemistry DNA Repair Enzymes - genetics DNA Repair Enzymes - metabolism DNA Replication Fanconi Anemia Complementation Group D2 Protein - metabolism Gene Expression Genomic Instability Histones - metabolism Humans Multiprotein Complexes - metabolism Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Protein Interaction Domains and Motifs Protein Transport Replication Protein A - metabolism Signal Transduction - drug effects Ubiquitination
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