Osteoblast maturation and new bone formation in response to titanium implant surface features are reduced with age

The surface properties of materials contribute to host cellular response and play a significant role in determining the overall success or failure of an implanted biomaterial. Rough titanium (Ti) surface microtopography and high surface free energy have been shown to enhance osteoblast maturation in...

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Veröffentlicht in:	Journal of bone and mineral research 2012-08, Vol.27 (8), p.1773-1783
Hauptverfasser:	Olivares-Navarrete, Rene, Raines, Andrew L, Hyzy, Sharon L, Park, Jung Hwa, Hutton, Daphne L, Cochran, David L, Boyan, Barbara D, Schwartz, Zvi
Format:	Artikel
Sprache:	eng
Schlagworte:	1,25‐DIHYDROXYVITAMIN D3 25-DIHYDROXYVITAMIN D3 AGE Age differences Aging - physiology Animals Biological and medical sciences Biomaterials Canals Cell culture Cell Differentiation - drug effects Cell number Free energy Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects Hormones Hydrophobic and Hydrophilic Interactions - drug effects Implants, Experimental Male Mice Mice, Inbred C57BL MICROSTRUCTURED TITANIUM OSSEOINTEGRATION OSTEOBLASTS Osteoblasts - cytology Osteoblasts - drug effects Osteoblasts - metabolism Osteocalcin Osteogenesis Osteogenesis - drug effects Osteoprotegerin Rats Rats, Sprague-Dawley Skeleton and joints Surface Properties Titanium Titanium - pharmacology Transforming growth factor Transforming growth factor- beta 1 Vascular endothelial growth factor vascularization Vertebrates: osteoarticular system, musculoskeletal system
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