Low-dose nesiritide in human anterior myocardial infarction suppresses aldosterone and preserves ventricular function and structure: a proof of concept study

Background:B-type natriuretic peptide (BNP, nesiritide) has anti-fibrotic, anti-hypertrophic, anti-inflammatory, vasodilating, lusitropic and aldosterone-inhibiting properties but conventional doses of BNP cause hypotension, limiting its use in heart failure.Objective:To determine whether infusion o...

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Veröffentlicht in:	Heart (British Cardiac Society) 2009-08, Vol.95 (16), p.1315-1319
Hauptverfasser:	Chen, H H, Martin, F L, Gibbons, R J, Schirger, J A, Wright, R S, Schears, R M, Redfield, M M, Simari, R D, Lerman, A, Cataliotti, A, Burnett, J C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cardiology. Vascular system Cardiovascular disease Clinical trials Coronary heart disease Enzymes Female Heart Heart attacks Heart failure Humans Kinases Male Medical sciences Middle Aged Mineralocorticoid Receptor Antagonists - administration & dosage Myocardial Infarction - drug therapy Myocardial Infarction - physiopathology Myocarditis. Cardiomyopathies Natriuretic Agents - administration & dosage Natriuretic Peptide, Brain - administration & dosage Peptides Recombinant Proteins - administration & dosage Rodents Stroke Volume - drug effects Studies Trends Vasodilator Agents - administration & dosage Ventricular Remodeling - drug effects
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